50 research outputs found
Catalytic constructive deoxygenation of lignin-derived phenols: new C–C bond formation processes from imidazole-sulfonates and ether cleavage reactions
Full text linkChemInform Abstract: Synthesis of Benzofuroquinolizine for α-2 Adrenoceptor Antagonist MK-912: An O-Analogue of the Pictet-Spengler Reaction.
No full textImproved Carbonylation of Heterocyclic Chlorides and Electronically Challenging Aryl Bromides.
No full textTotal Synthesis of the Calphostins:Â Application of Fischer Carbene Complexes and Thermodynamic Control of Atropisomers
No full textSynthesis of Phosphorodiamidate Oligonucleotide Dimers
No full textAzido nucleosides couple with phosphoramidites via an
initial iminophosphorane,
which eliminates acrylonitrile to generate the coupled dimer P(V)
product. The vulnerable phosphite triester intermediate is bypassed
entirely, making the methodology very suitable to solution-phase synthesis.
This new coupling protocol requires no protection of the 5′-OH
function and provides a new method of installing internucleosidic
phosphorodiamidate bonds with near quantitative yields
Palladium-Catalyzed Aminocarbonylation of Aryl Chlorides at Atmospheric Pressure: The Dual Role of Sodium Phenoxide
No full text
