Duplicate bill from L. Alavoine Co. to Ogden Goelet

https://digitalcommons.salve.edu/goelet-interior/1001/thumbnail.jp

Invoice from L. Alavoine Co. to Ogden Goelet

https://digitalcommons.salve.edu/goelet-interior/1009/thumbnail.jp

List of missing articles

https://digitalcommons.salve.edu/goelet-interior/1010/thumbnail.jp

Invoice from L. Alavoine Co. to Ogden Goelet; Invoice from J. D. Johnston

https://digitalcommons.salve.edu/goelet-interior/1005/thumbnail.jp

Letter from L. Alavoine Co. to Ogden Goelet

https://digitalcommons.salve.edu/goelet-interior/1000/thumbnail.jp

Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children

Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal recessive deficiencies of OAS1, OAS2, or RNASEL in five unrelated children with MIS-C. The cytosolic double-stranded RNA (dsRNA)-sensing OAS1 and OAS2 generate 2'-5'-linked oligoadenylates (2-5A) that activate the single-stranded RNA-degrading ribonuclease L (RNase L). Monocytic cell lines and primary myeloid cells with OAS1, OAS2, or RNase L deficiencies produce excessive amounts of inflammatory cytokines upon dsRNA or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stimulation. Exogenous 2-5A suppresses cytokine production in OAS1-deficient but not RNase L-deficient cells. Cytokine production in RNase L-deficient cells is impaired by MDA5 or RIG-I deficiency and abolished by mitochondrial antiviral-signaling protein (MAVS) deficiency. Recessive OAS-RNase L deficiencies in these patients unleash the production of SARS-CoV-2-triggered, MAVS-mediated inflammatory cytokines by mononuclear phagocytes, thereby underlying MIS-C

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men

Invoice and receipts from L. Alavoine Co. to Ogden Goelet

https://digitalcommons.salve.edu/goelet-interior/1002/thumbnail.jp

The emergence of linezolid resistance among Enterococci in intestinal microbiota of treated patients is unrelated to individual pharmacokinetic characteristics

Linezolid is an antimicrobial agent for the treatment of multiresistant Gram-positive infections. We assessed the impact of linezolid on the microbiota and the emergence of resistance and investigated its relationship with plasma pharmacokinetics of the antibiotic. Twenty-eight patients were treated for the first time with linezolid administered orally ( n = 17) or parenterally ( n = 11) at 600 mg twice a day. Linezolid plasma pharmacokinetic analysis was performed on day 7. Colonization by fecal enterococci, pharyngeal streptococci, and nasal staphylococci were assessed using selective media with or without supplemental linezolid. The resistance to linezolid was characterized. The treatment led to a decrease of enterococci, staphylococci, and streptococci in the fecal ( P = 0.03), nasal, and pharyngeal ( P< 0.01) microbiotas. The appearance of resistant strains was observed only in enterococci from the fecal microbiota between the 7th and 21st days of treatment in four patients ( 14.3%). The resistance was mainly due for the first time to the mutation G2447T in the 23S rRNA gene. No pharmacokinetic parameters were significantly different between the patients, regardless of the appearance of resistance. The emergence of linezolid resistance during treatment was observed only in the intestinal microbiota and unrelated to pharmacokinetic parameters. However, colonization by Grampositive bacteria was reduced as a result of treatment in all microbiotas

Evaluación del nivel de aceptabilidad para las variedades Italia, Napoleón y Redglobe en el mercado español Evaluation of the acceptability level for the Italy, Napoleon and Redglobe varieties on the spanish market

Con el objetivo de evaluar el nivel de aceptabilidad para tres variedades tardías de uva de mesa, la Unidad de Comercialización y Divulgación Agraria del Departamento de Economía y Ciencias Sociales Agrarias (E.T.S.I.Agrónomos), de la Universidad Politécnica de Madrid, realizó la presente investigación en octubre de 1999. Se utilizó el análisis sensorial en Sala de Catas como herramienta para la evaluación del nivel de aceptabilidad de tres variedades de uva de mesa. Se puso énfasis en conocer las posibles diferencias de carácter sensorial entre las variedades Itália, Redglobe y Napoleón, variedades que coinciden en su época de cosecha y comercialización en España. En los análisis hechos, la variedad Itália fue la más preferida. El sabor, seguido de la jugosidad, fueron los elementos determinantes en el proceso de aceptación de la uva.<br>Aiming to evaluate the acceptability level of three late varieties of table grape, the Unity of Comercialization and Agricultural Divulgation from the Department of Economy and Agricultural Social Science (E.T.S.I. Agrónomos), from the Politecnical University of Madri, accomplished this study in July 1999. The sensorial analysis was applied for the evaluation of the acceptability level of three varieties of table grape: Italy, Redglobe and Napoleon. This analysis attempted to know the possible differences of sensorial character among the varieties. In the Spanish orchards, these varieties reached the harvest ripening in the same period. The flavor, followed by the succulence, were the determinant elements in the process of accepting the grape