Golgi localized β1-adrenergic receptors stimulate Golgi PI4P hydrolysis by PLCε to regulate cardiac hypertrophy.

Increased adrenergic tone resulting from cardiovascular stress leads to development of heart failure, in part, through chronic stimulation of β1 adrenergic receptors (βARs) on cardiac myocytes. Blocking these receptors is part of the basis for β-blocker therapy for heart failure. Recent data demonstrate that G protein-coupled receptors (GPCRs), including βARs, are activated intracellularly, although the biological significance is unclear. Here we investigated the functional role of Golgi βARs in rat cardiac myocytes and found they activate Golgi localized, prohypertrophic, phosphoinositide hydrolysis, that is not accessed by cell surface βAR stimulation. This pathway is accessed by the physiological neurotransmitter norepinephrine (NE) via an Oct3 organic cation transporter. Blockade of Oct3 or specific blockade of Golgi resident β1ARs prevents NE dependent cardiac myocyte hypertrophy. This clearly defines a pathway activated by internal GPCRs in a biologically relevant cell type and has implications for development of more efficacious β-blocker therapies

Redefining government's role in agriculture in the nineties

The authors argue that government policies in agriculture have been costly and misdirected worldwide. For them, this inefficiency need not continue. The Urugauy Round is an ideal opportunity for developed and developing nations to strike a bargain. They suggest 1) making agricultural trade subject to the full discipline of the GATT by eliminating waivers and exemptions that have set agricultural commodities apart from other products in their treatment under the GATT, 2) bringing developing countries fully into the GATT, by eliminating their special status, 3) getting all countries to reform their agricultural policies, to reduce the many policy-induced distortions that plague the sector. The authors claim that such a bargain would result in a redefinition of governments'role in agriculture, increased sectoral efficiency nationally, and a more smoothly functioning and tightly knit world agricultural trading system.Crops&Crop Management Systems,Environmental Economics&Policies,Agricultural Knowledge&Information Systems,Economic Theory&Research,Agricultural Research

Bridging the Climate Information Gap: A Framework for Engaging Knowledge Brokers and Decision Makers in State Climate Assessments

Large-scale analyses like the National Climate Assessment (NCA) contain a wealth of information critical to national and regional responses to climate change but tend to be insufficiently detailed for action at state or local levels. Many states now engage in assessment processes to meet information needs for local authorities. The goals of state climate assessments (SCAs) should be to provide relevant, actionable information to state and local authorities, and to generate primary sources, build networks and inform stakeholders. To communicate local climate impacts to decision makers, SCAs should express credibility, salience and legitimacy. They can provide information (e.g., case studies, data sets) and connect stakeholders to the NCA and its process. Based on our experience in the Vermont Climate Assessment (VCA), we present a framework to engage decision makers in SCAs using a fluid network of scientific experts and knowledge brokers to conduct subject area prioritization, data analysis and writing. The VCA addressed economic, environmental and social impacts of climate change at local scales to increase resiliency and manage risk. Knowledge brokers communicated VCA findings through their own stakeholder networks. We include a qualitative impact evaluation, and believe our framework for interaction among scientists, knowledge brokers and stakeholders to be an effective structure for SCAs and a transformative experience for students

Reflections on reflection:Clarifying and promoting use in experienced coaches

BACKGROUND: We draw on the work of established scholars in the field of reflective practice who highlight its importance as a key cognitive skill for professionals to hold. While the substantive effect of engaging in reflective practice is emphasised in the literature, apparently coaches only spend a limited time learning about and engaging with it. OBJECTIVES: This study was conducted in two parts: Part 1 examined coaches’ knowledge of reflective practice and ascertained their perceived lack of value and use of reflective practice within their coaching. In response to the unexpected findings in Part 1, in Part 2, we instituted an educational intervention to further these participant coaches’ knowledge of Reflective Practice (RP) and facilitate its integration into their coaching practice. DESIGN: The present study utilised a mixed method design with semi-structured interviews being conducted in Part 1. A coach development reflective programme inspired by Stimulated Recall approach was implemented in Part 2. PARTICIPANTS: Twelve high level coaches were interviewed about their reflective practices in Part 1. In Part 2, the same coaches agreed to participate in the educational intervention for the duration of the project. RESULTS: Findings from Part 1 revealed an interesting paradox: coaches demonstrated a lack of appreciation for reflective practice yet recounted the positive influence that specific events and individuals had on their practice. In Part 2, to fully develop RP with the present cohort, an educational intervention was conducted. While watching videos of their own practice, coaches initially required lots of prompts from the lead interviewer to facilitate a deep and meaningful discussion of their practice. During the latter stages of the intervention, however, participants were less dependent on questions and prompts. CONCLUSION: In part 1, the coaches in this study did employ reflection, although they did not label it as such. The qualitative evidence we have gathered enables us to suggest that it is the combination of how to reflect, and against what criteria that makes RP a powerful tool to develop expertise which it has the potential to be. Importantly, however, additional coach education input is necessary for these benefits to be fully realised

Sub-types of nonbelieved memories reveal differential outcomes of challenges to memories

Nonbelieved memories (NBMs) highlight the independence between metamemorial judgments that contribute to the experience of remembering. Initial definitions of NBMs portrayed them as involving the withdrawal of autobiographical belief despite sustained recollection. While people rate belief for their NBMs as weaker than recollection, the average difference is too small to support the idea that belief is completely withdrawn in all cases. Furthermore, ratings vary considerably across NBMs. In two studies, we reanalyzed reports from prior studies to examine whether NBM reports reflect a single category or multiple sub-categories using cluster analytic methods. In Study 1, we identified three sub-types of NBMs. In Study 2 we incorporated the concept of belief in accuracy, and found that two of the clusters from Study 1 split into two clusters apiece. Higher ratings of recollection than belief in occurrence characterized all clusters, which were differentiated by the degree of difference between these variables. In both studies the clusters were differentiated by a number of memory characteristic ratings and by reasons reported as leading to the alteration of belief. Implications for understanding the remembering of past events and predicting the creation of NBMs are discussed

Views and Queries: Determinacy and Rewriting

International audienceWe investigate the question of whether a query Q can be answered using a set V of views. We first define the problem in information-theoretic terms: we say that V determines Q if V provides enough information to uniquely determine the answer to Q . Next, we look at the problem of rewriting Q in terms of V using a specific language. Given a view language V and query language Q , we say that a rewriting language R is complete for V -to- Q rewritings if every Q ∈ Q can be rewritten in terms of V ∈ V using a query in R , whenever V determines Q . While query rewriting using views has been extensively investigated for some specific languages, the connection to the information-theoretic notion of determinacy, and the question of completeness of a rewriting language have received little attention. In this article we investigate systematically the notion of determinacy and its connection to rewriting. The results concern decidability of determinacy for various view and query languages, as well as the power required of complete rewriting languages. We consider languages ranging from first-order to conjunctive queries

Toward a sustainable culture of peer partnership

This project is a two phase design working in partnership with five universities to develop, implement and systematically embed a distributive leadership model that aims to embed peer partnership (review, development) within the culture of teaching and learning excellence. This presentation will posit a ‘prototype’ peer review leadership model based on ongoing research that brings together both the fundamentals of peer review with the broader importance of context and persons. It will be argued that essential to teaching development is a need to address not only the implementation of peer partnership programs but also strategies to influence and change both the contexts of teaching and the advantages for colleagues. Peer review as a strategy to develop excellence in teaching needs to be considered from a holistic perspective encompassing all elements of the teaching environment. The emphasis is on working to foster the type of conditions needed for leadership and change to begin and be sustained. The work has implications for policy, research, leadership development and student outcomes and has potential application world-wide. Phase 1 has collected focus interview and questionnaire data to inform the research and is being analysed using a thematic qualitative approach and statistical analysis. Evidence is emerging currently as the project is ongoing

An exploration of an integrated counselling and coaching approach with distressed young people

This mixed methods study explored the effectiveness and experience of an integrated counselling and coaching approach with young people. An effectiveness study allocated 80 young people aged between 13 and 25 years from four Youth Information Advice and Counselling Services centres in England to two groups: an integrated counselling and coaching group, based on the Personal Consultancy (PC) model, and a humanistic counselling group. Self-report measures of distress were administered at baseline and endpoint. Findings of the quantitative analysis showed that although baseline distress levels between groups were equivalent, post-intervention levels were significantly lower in the integrated group. Interpretative Phenomenological Analysis of qualitative experiences from five young people from the integrated group explored possible reasons for these results. Five master themes emerged: making sense of past, present and/or future, developing a sense of agency, management of affect, enhancing interpersonal relationships and development of self. Findings indicated that young people responded well to the integrated treatment; attending to intra-psychic issues alongside their developmental challenges seemed to have a beneficial effect on their sense of agency in particular. In conclusion, PC may be an effective means of reducing distress in young people