Glocalization: an analysis into it’s conceptual and strategic underpinnings

Glocalization is a “simultaneity—the co-presence—of both universalizing and particularizing tendencies” emphasizing the need for tempering the effects of local conditions on global pressures. While the increasing presence of best-known fast food chain restaurants worldwide such as McDonald’s and KFC is a manifestation of globalization, the shrewd and strategic adaptations of their menu to satiate the local palates and tastes by these “Glocal Enterprises” is illustrative of glocalization. Conversely, the chief point of glocalization perspective is: “even the most local ways of carrying out business operations are more and more co-constituted by economic and social trends that are most global.” Language has a huge role to play in addressing the cultural and linguistic barriers and designing a successful global talent management and language learning solution that is complemented by local support. When used as an extension of the “Think Global, Act Local” grassroots movement, glocalization also refers to market advantage of local businesses versus global companies.  In the face of globalization, both the little guys and would-be entrepreneurs can emerge triumphant by tapping into their hometown markets and then scaling up. However, it is imperative that MNCs restructure the national economies to become and remain more resilient, sustainable, and inclusive in their globalization to glocalization migration odyssey.  An attempt would be made in this conceptual Paper to address this issue—a challenge and an opportunity—for the key players by enumerating the stories of successful transition into glocalization by several popular Multi National Corporations in the Indian context

Corporate learning in a disruptive digital era: a new global organizational paradigma (A case-study of IBM’s Your Learning Platform)

In a digital world when the technologies as well as the market places are evolving at an alarming pace, facilitating the employees to acquire newer knowledge and helping them advance their learning is most challenging than ever before. Staying agile and to become and remain ahead of competition in this swiftly changing business landscape is a daunting task indeed for companies. Corporate universities and Classrooms in B-schools have totally been overshadowed and got undermined by newer versions of learning and we are witnessing that the buffet of teaching employees is expanding and changing more than ever before. In addition to tracking down a plethora of in-person opportunities in the form of mentorships and training, employees are able to use their computers and smart phones to sift through facilely rich content online at any time and place. It may be in the form of online social media networks, published papers, as well as videos and courses. Nowadays, mobile and cloud technologies, and social networks are taken for granted by the tech-savvy modern employees. And not surprisingly, the millennials believe that technology makes them more effective and productive and hence always prefer to communicate through the electronic mode at workplace than face to face or for that matter even the telephone. They are found to be using technology only routinely. This Paper addresses the important challenge of shifting learning to the 21st Century platform economy faced by corporates and discusses how IBM has successfully tackled the same through its Your Learning Platform

Human resource planning using predictive analytics

Big Data, Analytics, Predictive Analytics (PA) have made their way into the world of Business in general and Human Resource Management in particular. Today, they have even gained an entry into Board rooms and business meetings as well. PA has immense potential to offer game changing actionable insights into the entire gamut of HR planning activities. In total contrast to the traditional descriptive analytics using tables, reports, ratios, metrics, etc., PA equips firms to analyze the past and attempts to discern trends in key HR-centric data. However, most companies woefully lack a holistic and consistent view of their HR and the incredible power of HR analytics to attempt and achieve employee force optimization. This review of literature-based Paper discusses the issues and challenges involved in using PA and Predictive Retention Modeling as a key component of HR analytics strategy to compete better and secure business excellence through analytic capability

The cloud Approach for Consistent Appropriate deduplication

In Cloud processing includes conveying gatherings of remote servers and programming systems that permit brought together information stockpiling and online access to PC administrations or assets. Mists can be named open, private or mixture. Cloud administration suppliers offer both exceedingly accessible capacity and hugely parallel registering assets at moderately low expenses. As Cloud computing gets to be pervasive, an expanding measure of information is being put away in the cloud and imparted by clients to indicated benefits, which characterize the entrance privileges of the put away information. One basic test of Cloud storage administrations is the administration of the constantly expanding volume of information. Datadeduplication is a particular information pressure strategy for wiping out copy duplicates of rehashing information. This method is utilized to enhance stockpiling usage and can likewise be connected to network information exchanges to diminish the quantity of bytes that must be sent and spare transmission capacity. To ensure the secrecy of delicate information while supporting deduplication, the merged encryption system is utilized to scramble the information before outsourcing. It encodes/unscrambles an information duplicate with a joined key, which is acquired by figuring the cryptographic hash estimation of the substance of the information duplicate. Focalized encryption permits the cloud to perform deduplication on the ciphertexts and the confirmation of possession keeps the unapproved client to get to the document. To improve the framework in security OAuth is utilized. OAuth (Open Authorization) is an open convention for token-construct confirmation and approval with respect to the Internet utilized as a part of half and half cloud to improve the security. OAuth empowers the framework to guarantee that the client is a verified individual or not. Just such confirmed client got the token for transferring and downloading in pubic cloud

Structural and kinetic analysis of an MsrA–MsrB fusion protein from Streptococcus pneumoniae

Methionine sulphoxide reductases (Msr) catalyse the reduction of oxidized methionine to methionine. These enzymes are divided into two classes, MsrA and MsrB, according to substrate specificity. Although most MsrA and MsrB exist as separate enzymes, in some bacteria these two enzymes are fused to form a single polypeptide (MsrAB). Here, we report the first crystal structure of MsrAB from Streptococcus pneumoniae (SpMsrAB) at 2.4 Å resolution. SpMsrAB consists of an N-terminal MsrA domain, a C-terminal MsrB domain and a linker. The linker is composed of 13 residues and contains one 310-helix and several hydrogen bonds interacting with both MsrA and MsrB domains. Interestingly, our structure includes the MsrB domain complexed with an SHMAEI hexa-peptide that is the N-terminal region of neighbouring MsrA domain. A kinetic analysis showed that the apparent Km of SpMsrAB for the R-form-substrate was 20-fold lower than that for the S-form substrate, indicating that the MsrB domain had a much higher affinity for the substrate than the MsrA domain. Our study reveals the first structure of the MsrAB by providing insights into the formation of a disulphide bridge in the MsrB, the structure of the linker region, and the distinct structural nature of active site of each MsrA and MsrB domain

Methionine Sulfoxide Reductases Are Essential for Virulence of Salmonella Typhimurium

Production of reactive oxygen species represents a fundamental innate defense against microbes in a diversity of host organisms. Oxidative stress, amongst others, converts peptidyl and free methionine to a mixture of methionine-S- (Met-S-SO) and methionine-R-sulfoxides (Met-R-SO). To cope with such oxidative damage, methionine sulfoxide reductases MsrA and MsrB are known to reduce MetSOs, the former being specific for the S-form and the latter being specific for the R-form. However, at present the role of methionine sulfoxide reductases in the pathogenesis of intracellular bacterial pathogens has not been fully detailed. Here we show that deletion of msrA in the facultative intracellular pathogen Salmonella (S.) enterica serovar Typhimurium increased susceptibility to exogenous H2O2, and reduced bacterial replication inside activated macrophages, and in mice. In contrast, a ΔmsrB mutant showed the wild type phenotype. Recombinant MsrA was active against free and peptidyl Met-S-SO, whereas recombinant MsrB was only weakly active and specific for peptidyl Met-R-SO. This raised the question of whether an additional Met-R-SO reductase could play a role in the oxidative stress response of S. Typhimurium. MsrC is a methionine sulfoxide reductase previously shown to be specific for free Met-R-SO in Escherichia (E.) coli. We tested a ΔmsrC single mutant and a ΔmsrBΔmsrC double mutant under various stress conditions, and found that MsrC is essential for survival of S. Typhimurium following exposure to H2O2, as well as for growth in macrophages, and in mice. Hence, this study demonstrates that all three methionine sulfoxide reductases, MsrA, MsrB and MsrC, facilitate growth of a canonical intracellular pathogen during infection. Interestingly MsrC is specific for the repair of free methionine sulfoxide, pointing to an important role of this pathway in the oxidative stress response of Salmonella Typhimurium

Methionine Sulfoxide Reductase A (MsrA) Deficient Mycoplasma genitalium Shows Decreased Interactions with Host Cells

Mycoplasma genitalium is an important sexually transmitted pathogen that affects both men and women. In genital-mucosal tissues, it initiates colonization of epithelial cells by attaching itself to host cells via several identified bacterial ligands and host cell surface receptors. We have previously shown that a mutant form of M. genitalium lacking methionine sulfoxide reductase A (MsrA), an antioxidant enzyme which converts oxidized methionine (Met(O)) into methionine (Met), shows decreased viability in infected animals. To gain more insights into the mechanisms by which MsrA controls M. genitalium virulence, we compared the wild-type M. genitalium strain (G37) with an msrA mutant (MS5) strain for their ability to interact with target cervical epithelial cell lines (HeLa and C33A) and THP-1 monocytic cells. Infection of epithelial cell lines with both strains revealed that MS5 was less cytotoxic to HeLa and C33A cell lines than the G37 strain. Also, the MS5 strain was more susceptible to phagocytosis by THP-1 cells than wild type strain (G37). Further, MS5 was less able to induce aggregation and differentiation in THP-1 cells than the wild type strain, as determined by carboxyfluorescein diacetate succinimidyl ester (CFSE) labeling of the cells, followed by counting of cells attached to the culture dish using image analysis. Finally, MS5 was observed to induce less proinflammatory cytokine TNF-α by THP-1 cells than wild type G37 strain. These results indicate that MsrA affects the virulence properties of M. genitalium by modulating its interaction with host cells

Expression during Host Infection and Localization of Yersinia pestis Autotransporter Proteins

Yersinia pestis CO92 has 12 open reading frames encoding putative conventional autotransporters (yaps), nine of which appear to produce functional proteins. Here, we demonstrate the ability of the Yap proteins to localize to the cell surface of both Escherichia coli and Yersinia pestis and show that a subset of these proteins undergoes processing by bacterial surface omptins to be released into the supernatant. Numerous autotransporters have been implicated in pathogenesis, suggesting a role for the Yaps as virulence factors in Y. pestis. Using the C57BL/6 mouse models of bubonic and pneumonic plague, we determined that all of these genes are transcribed in the lymph nodes during bubonic infection and in the lungs during pneumonic infection, suggesting a role for the Yaps during mammalian infection. In vitro transcription studies did not identify a particular environmental stimulus responsible for transcriptional induction. The primary sequences of the Yaps reveal little similarity to any characterized autotransporters; however, two of the genes are present in operons, suggesting that the proteins encoded in these operons may function together. Further work aims to elucidate the specific functions of the Yaps and clarify the contributions of these proteins to Y. pestis pathogenesis