The influence of nutritional factors and dietary patterns on the prevention and control of arterial hypertension: a review

Arterial hypertension is a growing public health problem worldwide with serious health consequences. However, hypertension can be prevented and controlled with a healthy diet and physical activity. For this reason, we conducted a search of recent articles and reviews on the influence of nutritional factors and dietary patterns on the prevention and control of arterial hypertension, then sifted and aggregated the data. Results showed that guidelines such as sodium restriction, weight control and moderate alcohol intake, improved diet (following the DASH diet or Vegetarian diet), and physical activity significantly impacted blood pressure control. Likewise, consuming less saturated fat with an increase in monounsaturated fatty acids and omega-3s, providing adequate calcium, magnesium, protein, vitamin D and fiber, and improving the antioxidant capacity of the diet also plays an important role in blood pressure control. In short, an appropriate diet combined with a healthy lifestyle will help achieve the best blood pressure, reduce cardiovascular risk factors, and thereby achieve many other health benefits.

INFLAMMATORY BOWEL DISEASE: CLINICAL FEATURES AND MANIFESTATIONS BEYOND THE BOWEL

Inflammatory bowel disease (IBD) encompasses a spectrum of diseases, with Crohn's disease (CD) and ulcerative colitis (UC) representing the two broadest subtypes of IBD. Multiple extraintestinal manifestations (EIMs) are more frequent in (IBD); 5% –50% of the patients might be affected. The most often implicated sites of manifestations are musculoskeletal and dermatological structures. However, while some symptoms like peripheral arthritis and erythema nodosum correlate with IBD progression, others have their own course of disease like axial arthropathy, gangrenosis of the pioderma and primary sclerosic cholangitis. This review would provide a summary of the most frequent EIMs and their prevalence.                                       Peer Review History: Received 31 May 2020; Revised 7 June; Accepted 4 July, Available online 15 July 2020 Academic Editor: Dr. Muhammad Zahid Iqbal, AIMST University, Malaysia, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file:                Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewer(s) detail: Dr. Md. Parwez Ahmad, National Medical College, Birgunj, Nepal, [email protected] Dr. George Zhu, Tehran University of Medical Sciences, Tehran, Iran, [email protected]

SARS-CoV-2: from origin to treatment and control management strategies

The emergence of novel coronavirus (SARS-CoV-2) is marked as the highest pathogenic coronavirus that has crossed from the hosts to the human population in the twenty-first century. The spreading of COVID-19 in different Chinese cities and around the world is travel-related viral spread with the unprecedented nosocomial outbreaks. It has also shown with high case-fatality rates, indeed to urgent prophylactic and therapeutic settings. Scientific advancements of the SARS-CoV-2 pandemic allowed for rapid progress to understand the epidemiology and pathogenesis of SARS-CoV-2. This review highlights the genomic structure of SARS-CoV-2 with the proposed roles of genotype and phenotype of SARS-CoV-2 in pathogenesis and discusses recent results supporting treatment strategies of COVID-19 with a particular focus on how these new insights may facilitate rational development of SARS-CoV-2 for targeted therapies in the future