2,5-Dibromo­pyridine

In the title compound, C5H3Br2N, C—H⋯N hydrogen-bonding inter­actions and Br⋯Br inter­actions [3.9418 (3) and 3.8986 (3) Å] connect the mol­ecules into planar sheets stacked perpendicular to the b axis. In addition, pyrid­yl–pyridyl inter­sheet π–π stacking inter­actions [centroid–centroid distance = 4.12 (1) Å] result in a three-dimensional network

Bis(2,6-diamino-3,5-dibromo­pyridinium) hexa­bromidostannate(IV)

The asymmetric unit of the title compound, (C5H6Br2N3)2[SnBr6], contains one cation and one half-anion in which the Sn atom is located on a crystallographic centre of inversion and is in a quasi-octa­hedral geometry. The crystal structure is assembled via hydrogen-bonding inter­actions of two kinds, N(pyridine/amine)—H⋯Br—Sn, along with C—Br⋯Br—Sn interactions [3.4925 (19) Å]. The cations are involved in π–π stacking, which adds an extra supra­molecularity as it presents a strong case of offset-face-to-face motifs [centroid–centroid distance = 3.577 (3) Å]. The inter­molecular hydrogen bonds, short Br⋯Br inter­actions and π–π stacking result in the formation of a three-dimensional supra­molecular architecture

Bis(2-bromo­pyridinium) hexa­chlorido­stannate(IV)

The asymmetric unit of the title compound, (C5H5BrN)2[SnCl6], contains one cation and one half-anion. The [SnCl6]2− anion is located on an inversion center and forms a quasi-regular octa­hedral arrangement. Hydrogen-bonding inter­actions of two kinds, viz. N—H⋯Cl—Sn and C—H⋯Cl—Sn, along with Cl⋯Br inter­actions [3.4393 (15) Å], connect the ions in the crystal structure into two-dimensional supra­molecular arrays. These supra­molecular arrays are arranged in layers approximately parallel to (110) built up from anions inter­acting with six symmetry-related surrounding cations

Docking, synthesis, and anticancer assessment of novel quinoline-amidrazone hybrids

A group of new amidrazone compounds that include a quinoline component was produced through the reaction of hydrazonyl chloride, derived from 6-aminoquinoline, with appropriate secondary cyclic amines. The new compounds were confirmed through 1H-NMR, 13C-NMR, FTIR, and HRMS, and further verified by single-crystal X-ray diffraction. The antitumor potential of the synthesized compounds was tested against lung cancer (A549) and breast cancer (MCF-7) cell lines. Among the compounds, the ethyl carboxylate and o-hydroxy phenyl piperazine derivatives (10d and 10g) exhibited the strongest activity against both cell lines, with IC50 values of 43.1 and 59.1 μM for the lung and breast cancer cell lines, respectively. Moreover, the most potent compounds were subsequently docked into the c-Abl kinase binding site (PDB code: 1IEP) as a possible anticancer mechanism. In-silico ADMET study shows acceptable pharmacokinetic properties, and the toxicity profile for the most potent compounds is non-carcinogenic

Acidic Polysaccharide Extracts from Gastrodia Rhizomes Suppress the Atherosclerosis Risk Index through Inhibition of the Serum Cholesterol Composition in Sprague Dawley Rats Fed a High-Fat Diet

Obesity is associated with a broad spectrum of cardio-metabolic disturbances, including atherosclerosis and cardiovascular disease (CDV). A high-fat diet has been shown to cause an elevation of the plasma cholesterol levels in humans, and the control of serum cholesterol has been demonstrated to be important in the prevention of CVD and atherosclerosis. The aims of this study were to demonstrate that crude and acidic polysaccharide extracts from Gastrodia rhizomes suppress atherosclerosis through the regulation of serum lipids in Sprague Dawley (SD) rats fed a high-fat diet. We examined the concentrations of serum lipids, including total cholesterol, triglycerides, high-density lipoproteins (HDL) cholesterol, and low-density lipoproteins (LDL) cholesterol, in SD rats fed a high-fat diet and evaluated the atherogenic index. Here, we show that both crude and acidic polysaccharide extracts from Gastrodia rhizomes inhibited the total cholesterol and LDL levels. Moreover, there was a significantly suppressed atherosclerosis risk due to the acidic polysaccharide extract from Gastrodia rhizome. Taken together, our results suggested that acidic polysaccharide extracts from Gastrodia rhizomes might be beneficial for lowering the incidence of CVD and atherosclerosis by reducing the de novo synthesis of total cholesterol and the LDL levels

Effets de composés polyphénoliques de vin et de raisins dans des modèles expérimentaux de pathologies chroniques : diabète et hypertension

Le rat traité par la streptozotocine correspond à un diabète insulinoprive sans insulino-dépendance. Dans cette étude, nous avons montré qu'aussi bien un extrait total de polyphénols issus du vin rouge, l'éthanol ou leur association, possédaient des propriétés antidiabétiques, l'action des polyphénols correspondant à une diminution de l'absorption de nourriture alors que celle de l'éthanol à une correction de l'état diabétique lui-même.Le régime enrichi en fructose mime le syndrome X humain. Nous avons montré pour la première fois que les polyphénols du vin ou du raisin prévenaient non seulement l'hypertension artérielle, mais également l'hypertrophie cardiaque. Ces effets sont associés à une baisse de la production de radicaux libres cardiaques et aortiques, eux-mêmes reliés à une diminution de l'expression de la NADPH oxydase membranaire. Nous avons également montré des effets différentiels des extraits polyphénoliques enrichis en différentes familles de polyphénols.MONTPELLIER-BU Pharmacie (341722105) / SudocPARIS-BIUP (751062107) / SudocSudocFranceF

Field induced spontaneous quasiparticle decay and renormalization of quasiparticle dispersion in a quantum antiferromagnet.

The notion of a quasiparticle, such as a phonon, a roton or a magnon, is used in modern condensed matter physics to describe an elementary collective excitation. The intrinsic zero-temperature magnon damping in quantum spin systems can be driven by the interaction of the one-magnon states and multi-magnon continuum. However, detailed experimental studies on this quantum many-body effect induced by an applied magnetic field are rare. Here we present a high-resolution neutron scattering study in high fields on an S=1/2 antiferromagnet C9H18N2CuBr4. Compared with the non-interacting linear spin-wave theory, our results demonstrate a variety of phenomena including field-induced renormalization of one-magnon dispersion, spontaneous magnon decay observed via intrinsic linewidth broadening, unusual non-Lorentzian two-peak structure in the excitation spectra and a dramatic shift of spectral weight from one-magnon state to the two-magnon continuum

Field induced spontaneous quasiparticle decay and renormalization of quasiparticle dispersion in a quantum antiferromagnet.

The notion of a quasiparticle, such as a phonon, a roton or a magnon, is used in modern condensed matter physics to describe an elementary collective excitation. The intrinsic zero-temperature magnon damping in quantum spin systems can be driven by the interaction of the one-magnon states and multi-magnon continuum. However, detailed experimental studies on this quantum many-body effect induced by an applied magnetic field are rare. Here we present a high-resolution neutron scattering study in high fields on an S=1/2 antiferromagnet C9H18N2CuBr4. Compared with the non-interacting linear spin-wave theory, our results demonstrate a variety of phenomena including field-induced renormalization of one-magnon dispersion, spontaneous magnon decay observed via intrinsic linewidth broadening, unusual non-Lorentzian two-peak structure in the excitation spectra and a dramatic shift of spectral weight from one-magnon state to the two-magnon continuum

Synthesis, physicochemical, thermal, and XRD/HSA interactions of mixed [Cu(Bipy)(Dipn)](X)2 complexes: DNA binding and molecular docking evaluation

Two water-soluble dicationic complexes, [Cu(bipy)(dipn)](BF4)2 (1) and [Cu(bipy)(dipn)](NO3)2 (2) (bipy = 2.2-bipyridine and dipn = dipropylenetriamine), were synthesized in high yields. The desired complexes were characterized by CHN-EA, UV–Vis, SEM, EDS, FT-IR, TGA, and XRD. The single-crystal XRD of [Cu(bipy)(dipn)](BF4)2 reflected that Cu(II) complex is formed in a distorted square pyramid configuration. The Hirshfeld surface analysis (HSA) confirmed more powerful atom–atom interaction, the hydrogen bonding in H…F, supporting the outcome of XRD. The influences of the CT-DNA/complexes were gathered by viscosity, CV, and electronic absorption measurements. The estimated binding constants (Kb) for 1 and 2 were 4.5 × 104 and 3.4 × 104 M−1, respectively. Complex 2 revealed slightly poorer DNA binding capability than 1. Eventually, the molecular docking of [Cu(bipy)(dipn)]+2 species was evaluated and demonstrated employing 1BNA-DNA segment.The authors appreciate the Deanship of Scientific Research at King Saud University for funding this research work through grant # RG-1440-141