İskemik İnmede TOAST ve BANFORD Sınıflaması ile Hemogram Parametrelerinin Mortalite Açısından Karşılaştırılması

Purpose: Patients with ischemic stroke who attends emergency departments frequently and have high mortality and morbidity. Purpose of this study is to determine risk groups of ischemic stroke patients by using TOAST and Banford classifications and search whether is there a relationship between red cell distribution width (RDW), mean platelet volume (MPV) and mortality. Methods: We included patients older than 18 years old and who attend-ed XXX Numune Research and Training Hospital Emergency Department throughout two years between 01.07.2014-30.06.2016, patients aged 18 years and older who were diagnosed with ischemic stroke and hospitalized and had sufficient file information were included. Results: We included 404 patients this study. In our study 53.2% (n=215) of all cases were male, 46.8% (n=189) were female. When we look patients age distribution range the biggest group was over 65 years group with 57.7% (n=233) rate. Patients were groupped according to TOAST and Banford classification. MPV and RDW values of patients according to TOAST classification were low risk group 8.3±1.6, 15.7±2.3 and high risk group 8.0±1.5, 16.0±2.4 (p=0,096, p=0,054) respectively. MPV and RDW values were 7.9±1.5, 15.8±2.1 and 8.2±1.6, 15.9±2.6 (p=0,167, p=0,943) respectively in low risk group and high risk group according to Banford classification of patients. Conclusion: There are current studies investigating the utility of hematologic parameters in predicting mortality in emergency department management of patients with ischemic stroke. In the light of the data we obtained in our study, it was concluded that hematological parameters, especially MPV and RDW values were not an effective parameter in determining the prognosis

OBEZ ÇOCUKLARDA BEYNİN DİFÜZYON AĞIRLIKLI MANYETİK REZONANS GÖRÜNTÜLEME BULGULARI

Aim: To evaluate Diffusion Weighted Magnetic Resonance Imaging (DW MRI) findings in hunger and satiety related centers of the Brain in Obese Children. Material and Methods: 91 participants were enrolled in the study and 41 of them diagnosed as obese, 19 of them as overweight and 31 of them as non-obese volunteers and ages were ranged between 4-16. Diffusion weighted echo-plantar images of these cases taken in b100, b600, b1000 and b2000 gradient values and for each case b values determined for 14 regions of brain which are related with hunger and satiety. These regions are hypothalamus, hippocampal gyrus, middle temporal cortex, insula, corpus striatum, cingulate gyrus, orbitofrontal cortex, thalamus, midbrain, amygdala, occipital cortex, dorsomedial frontal cortex, dorsolateral frontal cortex and cerebellum. Measurements made with b600, b1000 and b2000values on 14 regions determined on Apparent Diffusion Coefficient (ADC) map for each group. Results: In ours study we have found a statistically significant difference between control and obese group,control and overweighed group and overweighed and obese group in ADC values in comparison of b600, b1000 and b2000 (

Presence and severity of estrogen receptor-alpha expression in patients with simple steatosis and nash

Loss of estrogen receptor-alpha (ER-?) in the liver is associated with hepatic steatosis and inflammation.We conducted a study in order to investigate the presence and extent of ER-? expression in NASH, andits relationship with histological findings. Fifty-four patients with histologically confirmed NASH, 12patients with simple steatosis (SS), and 6 patients with normal liver tissue (NLT) were included. NASHactivity score and fibrosis score were calculated according to biopsy findings. Liver biopsy specimenswere immunohistochemically stained for ER-? expression. Nuclear ER-? expression percentage (stainingindex) was calculated. Mean staining index was significantly different across the NASH, SS, and NLT groups(6.3±9.9 vs. 22.1±26.4 vs. 44.2±24.8, respectively, p < 0.001 for all comparisons). Staining index wassignificantly higher in women than in men (19.4±22.2 vs. 7.9±15.3, respectively, p = 0.003). Stainingindex negatively correlated with serum ALT (r =-0.240; p = 0.04), fasting plasma glucose (r =-0.261;p = 0.027), and fibrosis score (r =-0.312; p = 0.011). As a conclusion, hepatic nuclear ER-? expressionpercentage (staining index) is lower in patients with NASH when compared to SS and NLT groups. Stainingindex is negatively correlated with serum ALT levels, plasma glucose, and fibrosis score. Further studiesare required to clarify the significance of ER-? expression in NASH

SAFRA YOLLARI PATOLOJİLERİNDE ÇOK KESİTLİ BİLGİSAYARLI TOMOGRAFİ VE ENDOSKOPİK KOLANJİOPANKREATOGRAFİ BULGULARININ KARŞILAŞTIRILMASI

Aim: To investigate diagnostic value of multidedector computed tomography (MDCT) using multiplanar reformation (MPR) and minimum intensity projection (MinIP) techniques with comparison of MDCT findings and endoscopic retrograde findings known as the “gold standart” in patients cholangiopancreatograph

Lack of association of hepatic estrogen receptor-alpha expression with histopathological and biochemical findings in chronic hepatitis C

Estrogens exert a protective effect against hepatic steatosis and fibrosis. Loss of estrogen receptor-alpha(ER- ) in the liver is associated with hepatic steatosis and inflammation in animal models. We conducteda study in order to investigate the presence and extent of ER- expression in HCV infection,and its relationship with histological and biochemical findings. Ninety biopsy-proven chronic hepatitis C(CHC) patients were enrolled in the study. Liver biopsy specimens were immunohistochemically stainedfor ER- expression. Nuclear ER- expression percentage was calculated. ER- was positive in 69 of thepatients (76%). ER- positive and negative groups were not significantly different in terms of age, gender,necroinflammatory activity, fibrosis, steatosis, serum levels of AST, ALT, ALP, GGT, and bilirubin. ER- expression percentage was not correlated with fibrosis, steatosis, necroinflammatory activity and biochemicalfindings. Although estrogens are known to be protective against fibrosis and steatosis in animalmodels, we did not find any significant correlation between ER- expression and histopathological andbiochemical findings in CHC patients. These findings should be verified in further large scale studies

Hepatocellular adenomas in the Turkish population: reclassification according to updated World Health Organization criteria

Aims Hepatocellular adenoma (HCA) is an uncommon liver neoplasm, and studies of HCA subtypes have been primarily limited to France, the USA, and Japan. The aim of this study was to describe the clinicopathological features of HCA subtypes in Turkey