Lossless Text Compression Technique Using Syllable Based Morphology

In this paper, we present a new lossless text compression technique which utilizes syllable-based morphology of multi-syllabic languages. The proposed algorithm is designed to partition words into its syllables and then to produce their shorter bit representations for compression. The method has six main components namely source file, filtering unit, syllable unit, compression unit, dictionary file and target file. The number of bits in coding syllables depends on the number of entries in the dictionary file. The proposed algorithm is implemented and tested using 20 different texts of different lengths collected from different fields. The results indicated a compression of up to 43%

Care needs and satisfaction with nursing care quality of cancer patients

Objective: This study aims to determine the relationships between care needs and satisfaction with nursing care quality of chemotherapy-treated cancer patients. Patients and Methods: This cross-sectional study was conducted between November and December 2021 in an Outpatient Chemotherapy Unit in Istanbul. The interview form consists of sociodemographic and treatment-related questions, cancer needs of patients, the satisfaction with the quality of nursing care. Results: Most of the participants were 55 years of age and older (61%), women (57.8%), had comorbid diseases (52.4%), and 48% were diagnosed with stage II cancer (48%). The care needs to be reported frequently by patients were mostly psychological and interpersonal communication. It was determined that the most important variables that increased the health care needs were perception by patients of their health status, age, stage of cancer, and the level of satisfaction they perceive together with the quality of nursing care. Conclusions: This study determined that patient care should be planned based on the factors affecting patient care needs and that care needs could decrease with increasing satisfaction with nursing care

Non-Commutative Batalin-Vilkovisky Algebras, Homotopy Lie Algebras and the Courant Bracket

We consider two different constructions of higher brackets. First, based on a Grassmann-odd, nilpotent \Delta operator, we define a non-commutative generalization of the higher Koszul brackets, which are used in a generalized Batalin-Vilkovisky algebra, and we show that they form a homotopy Lie algebra. Secondly, we investigate higher, so-called derived brackets built from symmetrized, nested Lie brackets with a fixed nilpotent Lie algebra element Q. We find the most general Jacobi-like identity that such a hierarchy satisfies. The numerical coefficients in front of each term in these generalized Jacobi identities are related to the Bernoulli numbers. We suggest that the definition of a homotopy Lie algebra should be enlarged to accommodate this important case. Finally, we consider the Courant bracket as an example of a derived bracket. We extend it to the "big bracket" of exterior forms and multi-vectors, and give closed formulas for the higher Courant brackets.Comment: 42 pages, LaTeX. v2: Added remarks in Section 5. v3: Added further explanation. v4: Minor adjustments. v5: Section 5 completely rewritten to include covariant construction. v6: Minor adjustments. v7: Added references and explanation to Section

Effects of the hippocampal deep brain stimulation on cortical epileptic discharges in penicillin - induced epilepsy model in rats

Aim: Experimental and clinical studies have revealed that hippocampal DBS can control epileptic activity, but the mechanism of action is obscure and optimal stimulation parameters are not clearly defined. The aim was to evaluate the effects of high frequency hippocampal stimulation on cortical epileptic activity in penicillin-induced epilepsy model. Material and Methods: Twenty-five Sprague-Dawley rats were implanted DBS electrodes. In group-1 (n=10) hippocampal DBS was off and in the group-2 (n=10) hippocampal DBS was on (185 Hz, 0.5V, 1V, 2V, and 5V for 60 sec) following penicillin G injection intracortically. In the control group hippocampal DBS was on following 8μl saline injection intracortically. EEG recordings were obtained before and 15 minutes following penicillin-G injection, and at 10th minutes following each stimulus for analysis in terms of frequency, amplitude, and power spectrum. Results: High frequency hippocampal DBS suppressed the acute penicillin-induced cortical epileptic activity independent from stimulus intensity. In the control group, hippocampal stimulation alone lead only to diffuse slowing of cerebral bioelectrical activity at 5V stimulation. Conclusion: Our results revealed that continuous high frequency stimulation of the hippocampus suppressed acute cortical epileptic activity effectively without causing secondary epileptic discharges. These results are important in terms of defining the optimal parameters of hippocampal DBS in patients with epilepsy

Elucidating the source–sink relationships of zinc biofortification in wheat grains: a review

Zinc (Zn) concentration in wheat grains is generally low, with an average value of around 28–30 mg/kg. Therefore, increasing wheat grain Zn concentration for better human health is the focus of HarvestPlus global initiatives. Source–sink interactions have been intensively studied for decades to enhance crop yield potential, but less on grain nutritional quality. This review applies concepts of source, sink, and their interactions to the study of wheat grain Zn nutrition and biofortification. Increasing Zn sources to wheat (via soil and foliar application) could directly enlarge available Zn in vegetative tissues and grain Zn sink. Rational nitrogen (N) supply increases grain Zn accumulation (N‐Zn synergism), but phosphorus (P) input generally decreases (P‐Zn antagonism), and the potassium (K) effect is unclear. Conventional and genetic breeding have potential to stimulate Zn flow from source to sink (uptake from soil, root‐to‐shoot translocation, and remobilization). However, a rational manipulation to establish a well‐coordinated source–sink relationship is required to finally realize the grain Zn target (40–50 mg/kg) and increase on‐farm crop yield. Future studies should focus more on fertilization modes adopted by farmers (uses of compound, slow/controlled release, and organic and microbial fertilizers) and develop integrated agronomic and genetic strategies for Zn biofortification. A highly systematic and mechanistic model includes (a) migration paths of Zn (particularly from leaves to different grain parts) using isotopic labeling methods, (b) cross‐talks between Zn and carbon, N, P, K, or other divalent cations, (c) inherent physiological and biochemical processes of enzymes and signaling phytohormones, and (d) complex genetic systems governing Zn homeostasis and their relationships with other nutrients, signaling molecules, and increase or dilution/penalty of yield under different environmental conditions (soil, water, and future climatic changes) and managements (breeding and fertilization). These aspects require further elucidation to fully unravel the “black box” of Zn flow from source to sink

Sleep disorders, depressive symptoms and health-related quality of life-a cross-sectional comparison between kidney transplant recipients and waitlisted patients on maintenance dialysis

BACKGROUND: Kidney transplantation is believed to improve health-related quality of life (HRQoL) of patients requiring renal replacement therapy (RRT). Recent studies suggested that the observed difference in HRQoL between kidney transplant recipients (Tx) vs patients treated with dialysis may reflect differences in patient characteristics. We tested if Tx patients have better HRQoL compared to waitlisted (WL) patients treated with dialysis after extensive adjustment for covariables. METHODS: Eight hundred and eighty-eight prevalent Tx patients followed at a single outpatient transplant clinic and 187 WL patients treated with maintenance dialysis in nine dialysis centres were enrolled in this observational cross-sectional study. Data about socio-demographic and clinical parameters, self-reported depressive symptoms and the most frequent sleep disorders assessed by self-reported questionnaires were collected at enrollment. HRQoL was assessed by the Kidney Disease Quality of Life Questionnaire. RESULTS: Patient characteristics were similar in the Tx vs WL groups: the proportion of males (58 vs 60%), mean +/- SD age (49 +/- 13 vs 49 +/- 12) and proportion of diabetics (17 vs 18%), respectively, were all similar. Tx patients had significantly better HRQoL scores compared to the WL group both in generic (Physical function, General health perceptions, Energy/fatigue, Emotional well-being) and in kidney disease-specific domains (Symptoms/problems, Effect- and Burden of kidney disease and Sleep). In multivariate regression models adjusting for clinical and socio-demographic characteristics, sleep disorders and depressive symptoms, the modality of RRT (WL vs Tx) remained independently associated with three (General health perceptions, Effect- and Burden of kidney disease) out of the eight HRQoL dimensions analysed. CONCLUSIONS: Kidney Tx recipients have significantly better HRQoL compared to WL dialysis patients in some, but not all, dimensions of quality of life after accounting for differences in patient characteristics. Utilizing multidimensional disease-specific questionnaires will allow better understanding of treatment, disease and patient-related factors potentially affecting quality of life in patients with chronic medical conditions

Systematic determination of the reproductive growth stage most sensitive to high night temperature stress in rice ( Oryza sativa )

High night‐temperature (HNT) stress during the reproductive stage of rice (Oryza sativa L.) reduces spikelet fertility and yield by inhibiting important physiological processes. However, specifics such as the period of time that is most sensitive to HNT, is unknown. To investigate this, we conducted four controlled‐environment experiments with two rice cultivars, N22 (HNT tolerant) and WAB56–104 (HNT susceptible). These cultivars were exposed to varying durations and intensities of night temperatures (control, 24°C; HNT, 30 and 35°C) during the reproductive stage. The effect of HNT on spikelet fertility and grain weight varied with duration: spikelet fertility reduced by 47–77% when exposed to HNT for 15 nights, 6–29% when exposed for four nights, and 9–15% when exposed for 5.5 h (pre‐midnight, 1830–0000 h or post‐midnight, 0000–0530 h) for four nights. Spikelet fertility and grain weight were most sensitive to HNT during the first 4 d of anthesis, compared with 1–4, 5–8, and 9–12 d before anthesis. At anthesis, reduction in spikelet fertility did not differ significantly between pre‐ and post‐midnight high‐temperature treatments. Our results suggest that greatest sensitivity to HNT during the reproductive stage occurs during the first 4 d of anthesis, providing a reference for future studies involving HNT tolerance in rice

Virologic and clinical characteristics of HBV genotypes/subgenotypes in 487 Chinese pediatric patients with CHB

<p>Abstract</p> <p>Background</p> <p>The association of hepatitis B virus (HBV) genotypes/subgenotypes with clinical characteristics is increasingly recognized. However, the virologic and clinical features of HBV genotypes/subgenotypes in pediatric patients remain largely unknown.</p> <p>Methods</p> <p>Four hundred and eighty-seven pediatric inpatients with CHB were investigated, including 217 nucleos(t)ide analog-experienced patients. HBV genotypes/subgenotypes and reverse transcriptase (RT) mutations were determined by direct sequencing. The stage of fibrosis and degree of inflammatory activity were evaluated by the Metavir score system.</p> <p>Results</p> <p>Among 487 enrolled pediatric patients, HBV genotype C2 and B2 were the most two prevalent (73.7% and 21.1%). Comparing with HBV/B2 infected patients, no significant difference was observed in the incidence rate and mutant patterns of lamivudine- or adefovir-resistant mutations in HBV/C2 infected patients (<it>P </it>> 0.05). Importantly, we found that the degree of hepatic inflammation degree, fibrosis stage and ALT level were significantly higher in HBV/C2-infected HBeAg positive patients than it was in HBV/B2-infected ones.</p> <p>Conclusions</p> <p>The pediatric patients with HBV/C2 infection might be more susceptible to develop severe liver pathogenesis.</p

An Integrated Qualitative and Quantitative Biochemical Model Learning Framework Using Evolutionary Strategy and Simulated Annealing

The authors would like to thank the support on this research by the CRISP Project (Combinatorial Responses In Stress Pathways) funded by the BBSRC (BB/F00513X/1) under the Systems Approaches to Biological Research (SABR) Initiative.Peer reviewedPublisher PD