ヒツジセッケッキュウノジョウチュウカンサニヨリユウドウサレルマウスチエンガタカビンショウ : ホンハンノウガツベルクリンガタチエンガタカビンショウデアルコトノショウコ

京都大学0048新制・課程博士医学博士甲第2054号医博第503号新制||医||240(附属図書館)5623UT51-53-C197京都大学大学院医学研究科外科系専攻(主査)教授 花岡 正男, 教授 安平 公夫, 教授 寺松 孝学位規則第5条第1項該当Kyoto UniversityDA

Cyclophosphamide eliminates suppressor T cells in age-associated central regulation of delayed hypersensitivity in mice

It has become increasingly apparent that subclasses of thymus-derived lymphocytes suppressively regulate cell-mediated immune phenomena such as graft-versus-host reaction (GvH) 1 (1, 2), cytotoxic allograft response (3), in vitro mixed lymphocyte reaction (MLR) (4), and contact delayed hypersensitivity (5). Recently, we reported on the T-T-cell interaction in delayed hypersensitivity (DH) response in mice induced by immunization with methylated human serum albumin (MHSA) in complete Freund's adjuvant (CFA), as revealed by cell transfer study and adult thymectomy (6). We suggested that the suppressor T cells regulated the DH in the induction stage. The suppressor activity was detected in such conventionally immunized mice, prominent in the young mouse thymus cells, but rare in the old mouse thymus cells or peripheral lymphocytes (6). On the other hand, DH seems to be regulated by humoral antibodies. There is an apparent inverse relationship between induction of humoral antibody response and DH reactivity (7, 8). Moreover, DH induction is inhibited by antibodies such as gammal-eontrasensitizing antibodies (9, 10). Pretreatment of guinea pigs with cyclophosphamid