Adiponectin and Cardiac Hypertrophy in Acromegaly

Background. Adiponectin is an adipocytes-derived hormone which has been shown to possess insulin-sensitizing, antiatherogenic, and anti-inflammatory properties. In acromegaly, the data on adiponectin is contradictory. The relationship between adiponectin levels and cardiac parameters has not been studied.Objectives. The aim of this study was to find out how adiponectin levels were affected in acromegalic patients and the relationship between adiponectin levels and cardiac parameters.Material and Methods. We included 30 subjects (15 male, 15 female), diagnosed with acromegaly and 30 healthy (10 male, 20 female) subjects. Serum glucose, insulin, GH, IGF-1 and adiponectin levels were obtained and the insulin resistance of the subjects was calculated. Echocardiographic studies of the subjects were performed.Results. We determined that adiponectin levels were significantly higher in the acromegalic group than the control group. In the acromegalic group, there was no statistically significant relation between serum adiponectin and growth hormone (GH), or insulin-like growth factor-1 (IGF-1) levels (p = 0.3, p = 0.1). We demonstrated that cardiac function and structure are affected by acromegaly. IVST, PWT, LVMI, E/A ratio, DT, ET, IVRT, VPR, and LVESV values were increased and the results were statistically significant. In the acromegalic group, adiponectin levels were positively related with left ventricle mass index (LVMI) but this correlation was found to be statistically weak (p = 0.03). In our study, there was a positive correlation between VAI and LVM. We also could not find any correlation between VAI and adiponectin levels.Conclusions. Although insulin resistance and high insulin levels occur in active acromegaly patients, adiponectin levels were higher in our study as a consequence of GH lowering therapies. Our study showed that adiponectin levels may be an indicator of the cardiac involvement acromegaly. However, the usage of serum adiponectin levels in acromegalic patients as an indicator of cardiac involvement should be supported with other, wide, multi-centered studies

Does Hypothyroidism Affect Gastrointestinal Motility?

Background. Gastrointestinal motility and serum thyroid hormone levels are closely related. Our aim was to analyze whether there is a disorder in esophagogastric motor functions as a result of hypothyroidism. Materials and Methods. The study group included 30 females (mean age ± SE 45.17 ± 2.07 years) with primary hypothyroidism and 10 healthy females (mean age ± SE 39.40 ± 3.95 years). All cases underwent esophagogastric endoscopy and scintigraphy. For esophageal scintigraphy, dynamic imaging of esophagus motility protocol, and for gastric emptying scintigraphy, anterior static gastric images were acquired. Results. The mean esophageal transit time (52.56 ± 4.07 sec for patients; 24.30 ± 5.88 sec for controls; P = .02) and gastric emptying time (49.06 ± 4.29 min for the hypothyroid group; 30.4 ± 4.74 min for the control group; P = .01) were markedly increased in cases of hypothyroidism. Conclusion. Hypothyroidism prominently reduces esophageal and gastric motor activity and can cause gastrointestinal dysfunction

Structure and photophysics of indigoids for singlet fission: Cibalackrot

We report an investigation of structure and photophysics of thin layers of cibalackrot, a sturdy dye derived from indigo by double annulation at the central double bond. Evaporated layers contain up to three phases, two crystalline and one amorphous. Relative amounts of all three have been determined by a combination of X-ray diffraction and FT-IR reflectance spectroscopy. Initially, excited singlet state rapidly produces a high yield of a transient intermediate whose spectral properties are compatible with charge-transfer nature. This intermediate more slowly converts to a significant yield of triplet, which, however, does not exceed 100% and may well be produced by intersystem crossing rather than singlet fission. The yields were determined by transient absorption spectroscopy and corrected for effects of partial sample alignment by a simple generally applicable procedure. Formation of excimers was also observed. In order to obtain guidance for improving molecular packing by a minor structural modification, calculations by a simplified frontier orbital method were used to find all local maxima of singlet fission rate as a function of geometry of a molecular pair. The method was tested at 48 maxima by comparison with the ab initio Frenkel-Davydov exciton model. Published under license by AIP Publishing

Enantioselective Oxidation of Thioanisole to Metyl Phenyl Sulfoxide by Chiral Compounds Bearing N

Chiral sulfoxides are used in asymmetric synthesis and are present in various biologically active compounds. Asymmetric synthesis of the sulfoxides has been performed by chiral metal complexes and non-metals containing peroxide and oxide moieties. In this study, a new metal free method has been developed to oxidize thioanisole into methyl phenyl sulfoxide with easily accessible chiral compounds carrying N-Cl bond. For this purpose, chiral amine and amide bearing reagents were synthesized and chlorinated by using N-chlorosuccinimide. In oxidation reactions, chiral information has been transferred from N-chloramines to sulfides. With chlorinated chiral reagents, we observed enantioenriched sulfoxide formation. Although the observed results are promising, the best chiral amines are yet to be found. This is the first report on such a reaction, to the best of our knowledge

Enantioselective Oxidation of Thioanisole to Metyl Phenyl Sulfoxide by Chiral Compounds Bearing <i>N</i>-Cl Bond

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Additive manufacturing process selection for automotive industry using Pythagorean fuzzy CRITIC EDAS

For many different types of businesses, additive manufacturing has great potential for new product and process development in many different types of businesses including automotive industry. On the other hand, there are a variety of additive manufacturing alternatives available today, each with its own unique characteristics, and selecting the most suitable one has become a necessity for relevant bodies. The evaluation of additive manufacturing alternatives can be viewed as an uncertain multi-criteria decision-making (MCDM) problem due to the potential number of criteria and candidates as well as the inherent subjectivity of various decision-experts engaging in the process. Pythagorean fuzzy sets are an extension of intuitionistic fuzzy sets that are effective in handling ambiguity and uncertainty in decision-making. This study offers an integrated fuzzy MCDM approach based on Pythagorean fuzzy sets for assessing additive manufacturing alternatives for the automotive industry. Objective significance levels of criteria are determined using the Criteria Importance Through Inter-criteria Correlation (CRITIC) technique, and additive manufacturing alternatives are prioritized using the Evaluation based on Distance from Average Solution (EDAS) method. A sensitivity analysis is performed to examine the variations against varying criterion and decision-maker weights. Moreover, a comparative analysis is conducted to validate the acquired findings

Additive manufacturing process selection for automotive industry using Pythagorean fuzzy CRITIC EDAS.

For many different types of businesses, additive manufacturing has great potential for new product and process development in many different types of businesses including automotive industry. On the other hand, there are a variety of additive manufacturing alternatives available today, each with its own unique characteristics, and selecting the most suitable one has become a necessity for relevant bodies. The evaluation of additive manufacturing alternatives can be viewed as an uncertain multi-criteria decision-making (MCDM) problem due to the potential number of criteria and candidates as well as the inherent subjectivity of various decision-experts engaging in the process. Pythagorean fuzzy sets are an extension of intuitionistic fuzzy sets that are effective in handling ambiguity and uncertainty in decision-making. This study offers an integrated fuzzy MCDM approach based on Pythagorean fuzzy sets for assessing additive manufacturing alternatives for the automotive industry. Objective significance levels of criteria are determined using the Criteria Importance Through Inter-criteria Correlation (CRITIC) technique, and additive manufacturing alternatives are prioritized using the Evaluation based on Distance from Average Solution (EDAS) method. A sensitivity analysis is performed to examine the variations against varying criterion and decision-maker weights. Moreover, a comparative analysis is conducted to validate the acquired findings

Search for a Small Chromophore with Efficient Singlet Fission: Biradicaloid Heterocycles

Of the five small biradicaloid heterocycles whose S₁, S₂, T₁, and T₂ adiabatic excitation energies were examined by the CASPT2/ANO-L-VTZP method, two have been found to meet the state energy criterion for efficient singlet fission and are recommended to the attention of synthetic chemists and photophysicists