Religious Discrimination and International Crises: International Effects of Domestic Inequality

Cataloged from PDF version of article.This paper explores religious discrimination against ethnic groups and foreign policy crisis linkages as part of the broader foreign policy approaches developed by McGowan and Shapiro (1973) and James and Özdamar (2005, 2008). Informed by the literature suggesting that domestic policies of repression and inequality may result in similar patterns of behavior internationally, this study tests whether states characterized by high levels of religious discrimination against ethnoreligious minorities are more likely to initiate or become involved in foreign policy crises with other states in general. A broad range of data sources, including an independently collected religious discrimination index, are used to test the hypothesized relationship between religious discrimination and international crisis during the period 1990-2003. The results suggest that religious discrimination is an important predictor of initiating and becoming involved in international crises. © 2013 International Studies Association

‘He wasn’t nice to our country’: children’s discourses about the ‘glocalized’ nature of political events in the Global North

The accessibility of new media combined with emerging patterns of migration are challenging current definitions of community as we see a shift from close-knit face-to-face interactions to more diverse ‘glocalized’ networks that defines community as a social rather than a spatial dimension. These changes mean that social connections, and fundamentally a person’s sense of belonging, have moved beyond a local neighbourhood to depend upon global networks. This was the case for the children in the current longitudinal ethnographic study that followed one class in a diverse primary school in the north of England every 2 years from their Reception year to Year 6. This article draws upon data collected while the children were in Year 6, aged 10 to 11. It uncovers the range of linguistic and semiotic resources that the children used to communicate with their school peers about two recent political events in the Global North, namely, the United Kingdom’s European Union (EU) Referendum in 2016 that has resulted in Brexit and the US Presidential Election in late 2016 and Donald Trump’s Inauguration in early 2017. Unearthing the ‘glocalized’ discourses in the children’s narratives, this article uncovers the connections that the children made between these political events and their nuclear family’s experiences living in the United Kingdom and their extended family’s experiences in their countries of origin. In providing an account of the children’s discourses surrounding these political events, this article uncovers the ways in which sociopolitical events of global significance become meaningful for this group of children and reveals that the children understand the global as situated, constructed within specific contexts and influenced by local interpretations. As the children orientate themselves to media depictions of these events, their shifting perceptions of global politics alongside their intersecting experiences of racial, national and religious inequalities come to the fore in their peer interactions at school

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p<0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p<0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised

30-Day morbidity and mortality of bariatric metabolic surgery in adolescence during the COVID-19 pandemic – The GENEVA study

Background: Metabolic and bariatric surgery (MBS) is an effective treatment for adolescents with severe obesity. Objectives: This study examined the safety of MBS in adolescents during the coronavirus disease 2019 (COVID-19) pandemic. Methods: This was a global, multicentre and observational cohort study of MBS performed between May 01, 2020, and October 10,2020, in 68 centres from 24 countries. Data collection included in-hospital and 30-day COVID-19 and surgery-specific morbidity/mortality. Results: One hundred and seventy adolescent patients (mean age: 17.75 ± 1.30 years), mostly females (n = 122, 71.8%), underwent MBS during the study period. The mean pre-operative weight and body mass index were 122.16 ± 15.92 kg and 43.7 ± 7.11 kg/m2, respectively. Although majority of patients had pre-operative testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (n = 146; 85.9%), only 42.4% (n = 72) of the patients were asked to self-isolate pre-operatively. Two patients developed symptomatic SARS-CoV-2 infection post-operatively (1.2%). The overall complication rate was 5.3% (n = 9). There was no mortality in this cohort. Conclusions: MBS in adolescents with obesity is safe during the COVID-19 pandemic when performed within the context of local precautionary procedures (such as pre-operative testing). The 30-day morbidity rates were similar to those reported pre-pandemic. These data will help facilitate the safe re-introduction of MBS services for this group of patients

30-day morbidity and mortality of sleeve gastrectomy, Roux-en-Y gastric bypass and one anastomosis gastric bypass: a propensity score-matched analysis of the GENEVA data

Background: There is a paucity of data comparing 30-day morbidity and mortality of sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), and one anastomosis gastric bypass (OAGB). This study aimed to compare the 30-day safety of SG, RYGB, and OAGB in propensity score-matched cohorts. Materials and methods: This analysis utilised data collected from the GENEVA study which was a multicentre observational cohort study of bariatric and metabolic surgery (BMS) in 185 centres across 42 countries between 01/05/2022 and 31/10/2020 during the Coronavirus Disease-2019 (COVID-19) pandemic. 30-day complications were categorised according to the Clavien–Dindo classification. Patients receiving SG, RYGB, or OAGB were propensity-matched according to baseline characteristics and 30-day complications were compared between groups. Results: In total, 6770 patients (SG 3983; OAGB 702; RYGB 2085) were included in this analysis. Prior to matching, RYGB was associated with highest 30-day complication rate (SG 5.8%; OAGB 7.5%; RYGB 8.0% (p = 0.006)). On multivariate regression modelling, Insulin-dependent type 2 diabetes mellitus and hypercholesterolaemia were associated with increased 30-day complications. Being a non-smoker was associated with reduced complication rates. When compared to SG as a reference category, RYGB, but not OAGB, was associated with an increased rate of 30-day complications. A total of 702 pairs of SG and OAGB were propensity score-matched. The complication rate in the SG group was 7.3% (n = 51) as compared to 7.5% (n = 53) in the OAGB group (p = 0.68). Similarly, 2085 pairs of SG and RYGB were propensity score-matched. The complication rate in the SG group was 6.1% (n = 127) as compared to 7.9% (n = 166) in the RYGB group (p = 0.09). And, 702 pairs of OAGB and RYGB were matched. The complication rate in both groups was the same at 7.5 % (n = 53; p = 0.07). Conclusions: This global study found no significant difference in the 30-day morbidity and mortality of SG, RYGB, and OAGB in propensity score-matched cohorts

CHAPTER 9: Biosynthesis of Curcumin and Molecular Targets and the Biological Mechanism of Curcumin

The biosynthesis of curcumin can be viewed from different perspectives, a natural pathway in Curcuma Longa (turmeric) and artificial pathways in Oryza sativa (rice) and rice bran pitch respectively, using Esterichia coli (E. Coli). The natural pathway for the synthesis of curcumin can be divided into two, an upstream and a downstream section. The transcription factor nuclear factor B (NF-B) governs several cellular signaling pathways associated with cancer, and targets various cytokines, proinflammatory molecules, growth factors, cell adhesion molecules, oncogenes and pro/anti-apoptotic proteins during carcinogenesis. Curcumin targets the transcription factors, protein kinases (PKs), angiogenesis, cell cycle regulators, sirtuins, NF-B signaling pathway, E-cadherin, vascular endothelial growth factor (VEGF), signal transducers and activators of the transcription 3 (STAT-3) signaling pathway, B-cell lymphoma (Bcl-2), p53, DNA, microRNA (miRNA), apoptosis and autophagy. The biological mechanism comprises different activities that are antioxidant, anticancer, antiviral, antifungal, antiproliferative, anti-immunomodulatory and anti-inflammatory. The main focus of this chapter is to provide valuable information on the biological synthesis, biological mechanism and molecular targets of curcumin. © 2021 The Royal Society of Chemistry

Religious discrimination and international crises: International effects of domestic inequality

This paper explores religious discrimination against ethnic groups and foreign policy crisis linkages as part of the broader foreign policy approaches developed by McGowan and Shapiro (1973) and James and Özdamar (2005, 2008). Informed by the literature suggesting that domestic policies of repression and inequality may result in similar patterns of behavior internationally, this study tests whether states characterized by high levels of religious discrimination against ethnoreligious minorities are more likely to initiate or become involved in foreign policy crises with other states in general. A broad range of data sources, including an independently collected religious discrimination index, are used to test the hypothesized relationship between religious discrimination and international crisis during the period 1990-2003. The results suggest that religious discrimination is an important predictor of initiating and becoming involved in international crises. © 2013 International Studies Association