28 research outputs found
Effects of Aminoguanidine on Glomerular Basement Membrane Thickness and Anionic Charge in a Diabetic Rat Model
We investigated the effect of aminoguanidine (AG)
administration on GBM thickness, glomerular heparan
sulfate (HS) content, and urinary albumin and
HS excretion in diabetic rats. After induction of
diabetes, female Wistar rats were divided into 2
groups: Group AGDM (n=11) received 1g/L aminoguanidine
bicarbonate in drinking water, group DC
(n=12) was given only tap water. Control rats received
AG (group AGH, n=8) or tap water (group
HC, n=8). At the end of a period of 8 weeks,
urinary albumin and glycosaminoglycan (GAG)
excretion was detected. GBM heparan sulfate distribution
and count was determined under the electron
microscope. The AGDM group had lower
urinary albumin and GAG excretion than diabetic
controls. GBM thickness was increased in diabetic
rats compared to groups of AGDM and HC. In
AGDM group alcian blue stained particle distribution
and count in the GBM was similar to healthy
controls. In conclusion AG prevents the decrease
of anionic charged molecules in the GBM and
GBM thickening. This can be one of the mechanisms
by which AG decreases albuminuria in diabetic
rats
The effect of physicians' awareness on influenza and pneumococcal vaccination rates and correlates of vaccination in patients with diabetes in Turkey An epidemiological Study "diaVAX"
We aimed to examine the effect of increased physician awareness on the rate and determinants of influenza and pneumococcal vaccinations in diabetic patients. Diabetic patients (n = 5682, mean [SD] age: 57.3 [11.6] years, 57% female) were enrolled by 44 physicians between Sept 2010 and Jan 2011. The physicians were initially questioned regarding vaccination practices, and then, they attended a training program. During the last five years, the physicians recommended influenza and pneumococcal vaccinations to 87.9% and 83.4% of the patients, respectively; however; only 27% of the patients received the influenza and 9.8% received the pneumococcal vaccines. One year after the training, the vaccination rates increased to 63.3% and 40.7%, respectively. The logistic regression models revealed that variables which increased the likelihood of having been vaccinated against influenza were: longer duration of diabetes, presence of hyperlipidemia and more use of concomitant medications whereas more use of anti-hyperglycemic medications was associated with increased odds of vaccination. On the other hand, older age, longer duration of diabetes and presence of a cardiovascular disease were variables which decreased the likelihood of having been vaccinated against pneumococcal disease during the past five years. However, during the study period, variables which decreased the odds of having been vaccinated included: older age and anti-hyperglycemic medications for influenza, and presence of hyperlipidemia and a family history of hypertension for pneumococcal disease. While variables which increased the likelihood of vaccination in the same period were: increased number of co-morbidities for influenza, and family history of diabetes for pneumococcal disease. We conclude that increased awareness of physicians may help improve vaccination rates against influenza and pneumococcal disease. However, diabetic patients with more severe health conditions are less likely to having been vaccinated. More structural/systematic vaccination programs are needed to increase the vaccination rates in patients with diabetes
Fever-induced Brugada syndrome in a 9-year-old boy presenting with acute chest pain
WOS: 000463332100016PubMed ID: 30968627Brugada syndrome, an arrhythmogenic disease, occurs due to mutations involving cardiac sodium channels. It is characterized by persistent or transient ST-segment elevation in the right precordial electrocardiogram leads that could be unmasked by several circumstances, with fever particularly. Molecular and cellular mechanisms leading to Brugada syndrome have not been completely elucidated. Mutations of the SCN5A gene encoding the pore-forming alpha-subunit of the cardiac sodium channel protein have been attributed in the molecular diagnosis. Although this syndrome is well-known in adults, it is less frequently reported in infants and children. We describe a 9-year-old Turkish boy with a family history of sudden cardiac death, who presented with chest pain and fever-induced expression of the Brugada syndrome phenotype that might be associated with a mutation in SCN5A gene