6 research outputs found
DIGESTIVE ENZYMES IN AFRICAN GIANT LAND SNAIL (ARCHACHATINA MARGINATA) DURING AESTIVATION
The activities of digestive enzymes in the gut
regions of African giant land snail, Archachatina
marginata were investigated during aestivation
induced in the laboratory by the withdrawal of
water and food for three weeks. All studied
enzymes, amylase, α-glucosidase, cellulase, lipase,
and protease, were detected on the gut regions
(oesophagus, crop, stomach and intestine).
Aestivated snails had significantly lower enzyme
activities in all the gut regions than the active
snails. Furthermore the stomach recorded the
highest enzyme activities of all the gut region
Total and CD4+ T- lymphocyte count correlation in newly diagnosed HIV patients in resource-limited setting
Few clinical settings in resource-limited countries perform CD4+ T-lymphocyte counts required as a
baseline test for antiretroviral therapy. We investigated CD4 count in newly diagnosed HIV-infected
patients attending our treatment centre and evaluated suitability of total lymphocyte count (TLC) as a
surrogate marker for CD4+T-lymphocyte count required as a yardstick for initiating antiretroviral
therapy. Usefulness of TLC as a surrogate marker for CD4+T-lymphocyte counts <200, â€350 and
<500cells/”L for HIV-positive patients in our facility was evaluated by 180 pairs of TLC and CD4 counts
from 180 newly diagnosed HIV-infected patients and results were compared by linear regression and
Spearmanâs correlation analytical tools. Approximately 72.8% of our patients were diagnosed late as
revealed by CD4 count â€350cells/”L. An overall good correlation was noted between TLC and CD4+Tcell counts (r=0.65, slope=0.69), m ean total lymphocyte count of 1.04 ± 0.81, 1.39 ± 1.06 and 1.57 ± 1.13 x
10âč/L correspond to CD4 lymphocyte counts of <200, â€350 and < 500cells/”L respectively. When
considering initiating HAART for HIV-infected Nigerian clients, TLC can be considered as an
inexpensive and easily accessible surrogate marker for predicting CD4+T-lymphocyte at two clinically
important CD4 thresholds of CD4 count of â€350 cells/”L and <500cells/”L