Forced Running Endurance Is Influenced by Gene(s) on Mouse Chromosome 10

Acknowledgments The authors wish to acknowledge technical assistance from Mrs. Indrė Libnickienė and intellectual input from Dr. David A. Blizard. This research was funded by the European Social Fund under the Global Grant measure. Grant VP1-3.1-ŠMM-07-K-02-057 was awarded to AL.Peer reviewedPublisher PD

The effect of high intensity interval exercise on postprandial triacylglycerol and leukocyte activation - monitored for 48h post exercise

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Regenerated soleus muscle shows reduced creatine kinase efflux after contractile activity in vitro

Date of Acceptance: 07/10/2014 Acknowledgements We are very grateful to Petras Jeneckas and Audrius Capskas for technical assistance. The study was supported by a grant (No. MIP-067/2012) from the Research Council of Lithuania.Peer reviewedPostprin

Myostatin dysfunction does not protect from fasting-induced loss of muscle mass in mice

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Fiber type composition affects resting ATP turnover estimated by NIRS in human ischemic muscle

The purpose of this study was to investigate effects of fiber type composition on resting ATP turnover at ischemic rest in human gastrocnemius (GC), tibialis anterior (TA) and soleus (SL) muscles using continuous-wave near-infrared spectroscopy (NIRS). Fiber type composition of the muscles was evaluated by histochemical analysis of muscle biopsies. Type I fiber occupied 54.0 ± 5.3, 62.2 ± 2.6 (p< 0.05) and 87.7 ± 3.3 % (p < 0.01, p < 0.05) of total fiber cross-section area in GC, TA and SL, respectively. Initial rate of decrease in muscle oxygenation by NIRS during ischemia was converted to resting ATP turnover rate using by muscle oxygen store at rest and a phosphate-to-oxygen ratio of 5.5. Resting ATP turnover rate was also corrected for muscle temperature decrease during the ischemic period. It was 0.281 ± 0.046, 0.277 ± 0.022 and 0.366 ± 0.046 mmol・(kg wet wt)-1・min-1 in GC, TA and SL, respectively. Resting ATP turnover rate correlated with the relative type I fiber area (r = 0.748, p < 0.01) for the pooled data of all three muscles. It is suggested that the relative type I fiber area is an important factor determining resting metabolic rate in human muscles in vivo. 本研究の目的は近赤外線分光法を用いて、虚血された腓腹筋、前脛骨筋およびヒラメ筋における安静時のATP代謝速度と筋線維組成の関係を検討することである。腓腹筋、前脛骨筋およびヒラメ筋の遅筋線維占有率はそれぞれ54.0 ± 5.3、62.2 ± 2.6（p < 0.05）および87.7 ± 3.3％（p < 0.01, p < 0.01）であった。近赤外線分光法によって測定された虚血初期の筋酸素化レベルの低下率は、安静時における筋内酸素貯蔵量とリン酸／酸素比（5.5）を用いて、安静時ATP代謝速度に変換された。また、安静時ATP代謝速度を、虚血時における筋温の低下を考慮して補正した。腓腹筋、前脛骨筋およびヒラメ筋における安静時ATP代謝速度はそれぞれ、0.281 ± 0.046、0.277 ± 0.022および0.366 ± 0.046 mmol（kg wet wt）?1・min?1であった。各筋の値をまとめると、安静時のATP代謝速度は遅筋線維占有率と有意な正の相関関係（r = 0.748, p < 0.01）にあった。以上の結果から、遅筋線維占有率はin vivoの測定においても、安静時代謝量を決定する重要な要因であると示唆される

Resolving candidate genes of mouse skeletal muscle QTL via RNA-Seq and expression network analyses

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H55N polymorphism is associated with low citrate synthase activity which regulates lipid metabolism in mouse muscle cells

Funding: This work was supported, in whole or in part, by European Social Fund under the Global Grant measure Grant VP1-3.1-ŠMM-07-K-02-057 (to A.L.), European Foundation for the Study of Diabetes grant (to T.V.), NHS Grampian Endowment grant (to A.R. and S.R.G.), Kuwait Ministry of Health grant (to M.A.), Saudi Ministry of Higher Education grant (to Y.A.,) as well as Saltire scholarship, Wenner-Gren Foundation Postdoctoral Fellowship, Albert Renold Travel Fellowship and a Novo Nordisk Foundation Challenge Grant (to B.G.).Peer reviewedPublisher PD

A longitudinal study of muscle rehabilitation in the lower leg after cast removal using Magnetic Resonance Imaging and strength assessment

Acknowledgements We thank the A&E nurses and plaster technicians for identifying suitable patients, the MRI radiographers for performing the scanning, Dr Scott Semple for invaluable help in some of the pilot studies and Mr E. C. Stevenson for constructing the footrest used in the scanner. We are very grateful to the dedicated patients themselves who gave considerable amounts of time to come in for scanning, exercise and assessment during the course of this study.Peer reviewedPublisher PD

Stanniocalcin-2 inhibits skeletal muscle growth and is upregulated in functional overload-induced hypertrophy

ACKNOWLEDGMENTS The authors gratefully acknowledge the Microscopy and Histology Core Facility for their support and assistance in this work. The work presented here was supported as follows. AL: Awards AR052879 and AR056280 from the National Institute of Arthritis, Musculoskeletal and Skin Diseases; award 249156 from the FP7-PEOPLE-2009-RG programme, award CGA/18/05 from the Chief Scientist Office, award 21/019 from the NHS Grampian Research Endowment. AL, GSB and LKH: award 204815/Z/16/Z from the Wellcome Trust. AIHC: The Providence Airway Centre, the St. Paul's Foundation and the Michael Smith Foundation for Health Research trainee award (RT-2021-1591). LKH: Biotechnology and Biological Sciences Research Council (BB/R01857X/1, BB/V016849/1). CO: Independent Research Fund Denmark (201930362460).Peer reviewedPublisher PD

Low Citrate Synthase Activity Is Associated with Glucose Intolerance and Lipotoxicity

This work was supported by Saudi Ministry of Higher Education Grant (to Y.A.), NHS Grampian Endowment Grant (no. 12/21) (to A.R. and S.R.G.), Kuwait Ministry of Health grant (to M.A.T.), and European Social Fund under the Global Grant Measure (VP1-3.1-ŠMM-07-K-02-057) (to A.L. and A.R.). The authors thank Shona Fleming of the School of Biological Sciences, University of Aberdeen, for the technical assistance during their study. The data used to support the findings of this study are available from the corresponding author upon request. A corrigendum for this article has been published.Peer reviewedPublisher PD