Fokin, Andrej

Kvedaras, Mindaugas

Lionikas, Arimantas

Minderis, Petras

Ratkevicius, Aivaras

Venckunas, Tomas

English

OBJECTIVES: The aim of the study was to investigate if myostatin dysfunction can ameliorate fasting-induced muscle wasting. METHODS: 18-week old males from Berlin high (BEH) strain with myostatin dysfunction and wild type myostatin (BEH+/+) strain were subjected to 48-h food deprivation (FD). Changes in body composition as well as contractile properties of soleus (SOL) and extensor digitorum longus (EDL) muscles were studied. RESULTS: BEH mice were heavier than BEH+/+ mice (56.0±2.5 vs. 49.9±2.8 g, P0.05), but only BEH mice experienced wasting of the gastrocnemius, tibialis anterior and plantaris muscles. FD induced a marked decrease in specific muscle force of SOL. EDL of BEH mice tended to be protected from this decline. CONCLUSION: Myostatin dysfunction does not protect from loss of muscle mass during fasting

Fokin, A

Minderis, P

Venckunas, T

Lionikas, A

Kvedaras, M

Ratkevicius, A

Queen Mary Research Online

Myostatin dysfunction does not protect from fasting-induced loss of muscle mass in mice.

Fokin, Andrej,

Minderis, Petras,

Venckunas, Tomas,

Lionikas, Arimantas,

Kvedaras, Mindaugas,

Ratkevicius, Aivaras,

Lithuanian Sports University Virtual Library

Myostatin dysfunction does not protect from fasting-induced loss of muscle mass in mice /

Aberdeen University Research

Myostatin dysfunction does not protect from fasting-induced loss of muscle mass in mice

https://aura.abdn.ac.uk/bitstream/2164/12956/1/Fokin_etal_JMNI_19_342_VOR.pdf

Myostatin dysfunction does not protect from fasting-induced loss of muscle mass in mice

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Queen Mary Research Online

Lithuanian Sports University Virtual Library

Aberdeen University Research