Penurunan Skala Nyeri Penderita Endometriosis Sebelum Dan Sesudah Pembedahan Laparoskopi Konservatif Dengan Atau Tanpa Diikuti Terapi Medikamentosa Di RSUD Dr. Soetomo

Tujuan: Mengetahui Perubahan keluhan nyeri penderita endo-metriosis sebelum dan sesudah pembedahan laparoskopi konservatif dengan atau tanpa diikuti terapi medikamentosa di RSUD dr. Soetomo.Bahan dan Metode: Studi ini merupakan penelitian deskriptif analitik pada penderita dengan keluhan nyeri panggul yang dicurigai menderita endometriosis dan akan dilakukan pembedahan laparoskopi konservatif serta memenuhi kriteria inklusi dan eksklusi. Subyek penelitian dievaluasi skala keluhan nyeri panggul kronik, dismenorea, dan dispareunia sebelum dilakukan laparoskopi dan setelah dilakukan laparoskopi pada bulan ke-1, bulan ke-2 dan bulan ke-3 dengan menggunakan skala numerik verbal mulai 0 sampai 10. Terapi medikamentosa yang diterima penderita setelah laparoskopi konservatif juga dicatat. Studi ini dilakukan si RSUD dr.Soetomo bulan Juli sampai Desember 2013.Hasil: Didapatkan 28 penderita yang memenuhi kriteria inklusi dan eksklusi serta dilakukan pembedahan laparoskopi konservatif, 2 penderita putus uji dan 26 penderita diikuti sampai bulan ke-3 pascapembedahan. Rata-rata skor r-AFS endometriosis 26,27 (rentang 3-60). Berdasarkan uji Wilcoxon, pada 1 bulan pertama didapatkan Perubahan rata-rata skala nyeri panggul kronik 0,92 ± 0,24 (p:0,002), dismenorea 2,77 ± 0,33 (p:0,000) dan dispareunia 0,15 ± 0,07 (p:0,046). Pada interval bulan 1 dan bulan 2, didapatkan Perubahan rata-rata skala nyeri panggul kronik 0,23 ± 0,10 (p:0,02), dismenorea 0,85 ± 0,19 (p:0,001). Pada interval bulan 2 dan bulan 3, didapatkan Perubahan rata-rata skala nyeri panggul kronik 0,15 ± 0,09 (p:0,10), dismenorea 0,31 ± 0,10 (p:0,014).Simpulan: Tidak didapatkan Perubahan skala dispareuni pada interval bulan 1 dan bulan 2 maupun bulan 2 dan bulan 3. Penurunan bermakna skala nyeri kronik terjadi sampai 2 bulan, penurunan bermakna skala dismenorea terjadi sampai 3 bulan, dan penurunan bermakna skala dispareuni terjadi sampai 1 bulan setelah pembedahan laparoskopi konservatif

Simulation of rock infiltration systems

Rain gardens, infiltration trenches, and dry detention ponds are widely used to treat runoff from construction site and urban watersheds. These infiltration systems have the potential to remove contaminants by filtration, but they also may become clogged with deposited sediment and other debris. An overview of studies done at the University of Minnesota over the past 10 years to investigate the trapping of sediment and the corresponding changes in permeabilities is presented. They include experimental data collected from the laboratory cores, a prototype dry detention basin, and field studies as well as the development of algorithms used in the WATER (Watershed Assessment Tool for Environmental Risk) model

Dimension-independent Harnack inequalities for subordinated semigroups

Dimension-independent Harnack inequalities are derived for a class of subordinate semigroups. In particular, for a diffusion satisfying the Bakry-Emery curvature condition, the subordinate semigroup with power $\alpha$ satisfies a dimension-free Harnack inequality provided $\alpha \in(1/2, 1)$, and it satisfies the log-Harnack inequality for all $\alpha \in (0,1).$ Some infinite-dimensional examples are also presented

Identification of Structural Variation in Chimpanzees Using Optical Mapping and Nanopore Sequencing.

Recent efforts to comprehensively characterize great ape genetic diversity using short-read sequencing and single-nucleotide variants have led to important discoveries related to selection within species, demographic history, and lineage-specific traits. Structural variants (SVs), including deletions and inversions, comprise a larger proportion of genetic differences between and within species, making them an important yet understudied source of trait divergence. Here, we used a combination of long-read and -range sequencing approaches to characterize the structural variant landscape of two additional Pan troglodytes verus individuals, one of whom carries 13% admixture from Pan troglodytes troglodytes. We performed optical mapping of both individuals followed by nanopore sequencing of one individual. Filtering for larger variants (>10 kbp) and combined with genotyping of SVs using short-read data from the Great Ape Genome Project, we identified 425 deletions and 59 inversions, of which 88 and 36, respectively, were novel. Compared with gene expression in humans, we found a significant enrichment of chimpanzee genes with differential expression in lymphoblastoid cell lines and induced pluripotent stem cells, both within deletions and near inversion breakpoints. We examined chromatin-conformation maps from human and chimpanzee using these same cell types and observed alterations in genomic interactions at SV breakpoints. Finally, we focused on 56 genes impacted by SVs in >90% of chimpanzees and absent in humans and gorillas, which may contribute to chimpanzee-specific features. Sequencing a greater set of individuals from diverse subspecies will be critical to establish the complete landscape of genetic variation in chimpanzees