An Exploration of regeneration and partnership workings in the London Borough of Merton.

This project examined how organizations working together to regenerate Merton view regeneration and the requirements for successful partnerships. Twenty-two, semi-standardized interviews were conducted with representatives from a variety of organizations in Merton. Using qualitative analysis, similarities and differences in responses were explored. This information along with background research was used to draw conclusions on whether these organizations have a mutually consistent understanding of regeneration and partnership work. Conclusions also discuss the implications of these findings

Performance of horseshoe padding materials

This project integrated biology and engineering to develop a procedure to quantify the functional performance of commercially sold horseshoe pads. Research resulted in a mathematical viscoelastic model describing deformation behavior. A review of equine anatomy was completed to determine the benefits and biological ramifications of viscoelastic materials on equine forelimbs. Finally, a device and experimental protocol were identified to quantify the deformation of horseshoe pads due to the ground reaction forces experienced by horses during future locomotion studies

Vulval premalignant lesions: a review article

Vulvar intraepithelial neoplasia (VIN) is a noninvasive squamous lesion that is a precursor of vulvar squamous cell cancer. Currently, no screening tests are available for detecting VIN, and a biopsy is performed to confirm the clinical diagnosis. Despite sharing many risk factors with cervical intraepithelial neoplasia, the diagnosis of VIN is poses challenges, contributing to its increasing prevalence. This study aimed to analyze the underlying risk factors that contribute to the development of VIN, identify specific populations at risk, and define appropriate treatment approaches. Differentiated VIN (dVIN) and usual VIN (uVIN) are the classifications of VIN. While dVIN is associated with other vulvar inflammatory disorders, such as lichen sclerosis, the more prevalent uVIN is associated with an underlying human papillomavirus infection. Patients with differentiated VIN have an increased risk of developing invasive malignancies. Few effective surveillance or management techniques exist for vulvar intraepithelial neoplasia, a preinvasive neoplasm of the vulva. For suspicious lesions, a thorough examination and focused biopsy are necessary. Depending on the specific needs of each patient, a combination of surgical and medical approaches can be used

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Not AvailableTerminal heat stress severely affects the growth of wheat crop causing drastic reduction in the yield and nutritional quality of the grains. Various technologies have been developed in the past to alleviate the effect of terminal heat stress (HS) in wheat, but with limited success. Silicon (Si), being quasi-essential element, has many beneficial advantages to the plants. Here, we observed exogenous application of 2.5 mM Si to be very effective in modulating the thermo-tolerance and quality of the grains. The application of Si2.5 has been observed to trigger the expression of signalling molecules (MAPK, CDPK), and stress-associated genes (SAGs) like HSFs (HD97, HSFA6e), HSPs (HSP17, HSP23, HSP70 and HSP90) and genes of antioxidant enzyme (GPX and SOD) under HS. Thermo-tolerant wheat cv. HD3086 showed more abundance of SAGs transcripts, as compared to thermo-susceptible cv. BT-Schomburgk. We observed increase in the accumulation of photosynthetic enzyme (RuBisCo activase) in leaves and storage protein (gliadin) in wheat grains under Si2.5 treatment. Heat stress downregulates the expression of genes linked with starch biosynthesis pathway; the percent decrease observed was minimum under Si2.5 treatment. Improved grain quality in both cvs. in response to Si2.5 under HS was observed. Si2.5 inhibits the activity of starch-degrading enzyme in endospermic tissue of grains. Si2.5 application was very effective, cheap and non-hazardous for mitigating the effect of terminal HS in wheat, stabilizing yield without compromising the quality of the grains.Not Availabl

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Not AvailableTerminal heat stress has detrimental effect on the growth and yield of wheat. Very limited information is available on heat stress-associated active proteins (SAAPs) in wheat. Here, we have identified 159 protein groups with 4271 SAAPs in control (22 +/- 3 degrees C) and HS-treated (38 degrees C, 2h) wheat cvs. HD2985 and HD2329 using iTRAQ. We identified 3600 proteins to be upregulated and 5825 proteins to be downregulated in both the wheat cvs. under HS. We observed 60.3% of the common SAAPs showing upregulation in HD2985 (thermotolerant) and downregulation in HD2329 (thermosusceptible) under HS. GO analysis showed proton transport (molecular), photosynthesis (biological), and ATP binding (cellular) to be most altered under HS. Most of the SAAPs identified were observed to be chloroplast localized and involved in photosynthesis. Carboxylase enzyme was observed most abundant active enzymes in wheat under HS. An increase in the degradative isoenzymes (/-amylases) was observed, as compared to biosynthesis enzymes (ADP-glucophosphorylase, soluble starch synthase, etc.) under HS. Transcript profiling showed very high relative fold expression of HSP17, CDPK, Cu/Zn SOD, whereas downregulation of AGPase, SSS under HS. The identified SAAPs can be used for targeted protein-based precision wheat-breeding program for the development of climate-smart' wheat.Indian Council of Agriculture Research (ICAR) under National Innovation on Climate Resilient Agriculture (NICRA) project [12/115 TG 3079]CABin project [(21-56) TG3064

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Not AvailableTerminal heat stress has detrimental effect on the growth and yield of wheat. Very limited information is available on heat stress-associated active proteins (SAAPs) in wheat. Here, we have identified 159 protein groups with 4271 SAAPs in control (22 ± 3 °C) and HS-treated (38 °C, 2 h) wheat cvs. HD2985 and HD2329 using iTRAQ. We identified 3600 proteins to be upregulated and 5825 proteins to be downregulated in both the wheat cvs. under HS. We observed 60.3% of the common SAAPs showing upregulation in HD2985 (thermotolerant) and downregulation in HD2329 (thermosusceptible) under HS. GO analysis showed proton transport (molecular), photosynthesis (biological), and ATP binding (cellular) to be most altered under HS. Most of the SAAPs identified were observed to be chloroplast localized and involved in photosynthesis. Carboxylase enzyme was observed most abundant active enzymes in wheat under HS. An increase in the degradative isoenzymes (α/β-amylases) was observed, as compared to biosynthesis enzymes (ADP-glucophosphorylase, soluble starch synthase, etc.) under HS. Transcript profiling showed very high relative fold expression of HSP17, CDPK, Cu/Zn SOD, whereas downregulation of AGPase, SSS under HS. The identified SAAPs can be used for targeted protein-based precision wheat-breeding program for the development of 'climate-smart' wheat.Not Availabl