Bifidobacterium infantis strains with and without a combination of Oligofructose and Inulin (OFI) attenuate inflammation in DSS-induced colitis in rats

BACKGROUND: Pathogenesis of inflammatory bowel disease is thought to be through different factors and there is a relationship between the gut flora and the risk of its development. Probiotics can manipulate the microflora in chronic inflammation and may be effective in treating inflammation. Bifidobacterium are saccharolytic and their growth in the gut can be promoted by non-absorbable carbohydrates and its increase in the colon appears to be of benefit. METHODS: Oligofructose and inulin (OFI) alone and the two B. infantis DSM 15158 and DSM 15159 with and without OFI, were fed to Sprague-Dawley rats for 7 days prior to colitis induction and administrations continued for another 7 days with the DSS. Colitis severity assessed using a Disease Activity Index. Samples were collected 7 days after colitis induction, for intestinal bacterial flora, bacterial translocation, short chain fatty acids (SCFAs), myeloperoxidase (MPO), cytokines (IL-1β, TNF-α, IL-10 and TGF-β) and malondialdehyde (MDA). RESULTS: OFI alone or the B. infantis strains with and without OFI improved significantly the DAI and decreased colonic MPO activity. Colonic tissue IL-1β decreased significantly in all treated groups except B. infantis DSM 15158. MDA decreased significantly in B. infantis DSM 15159 with and without OFI compared to colitis control. Succinic acid increased significantly in OFI group with and without DSM 15159 compared to all groups. Sum values of propionic, succinic acid and butyric acid increased significantly in all groups compare to the colitis control. Bacterial translocation to mesenteric lymph nodes decreased significantly in all groups compared to colitis control. Translocation to the liver decreased significantly in all groups compare to the colitis control and OFI + B. infantis DSM 15158 groups. CONCLUSION: Administrations of OFI and Bifidobacterium improve DSS-induced acute colitis and have an anti-inflammatory effect. Major differences in effect were observed between the two B. infantis strains as indicated in MDA and succinic acid concentration as well as bacterial translocation rate in synbiotic combinations

Delvis människa, delvis organisation

Partly human, partly organization In this article the phenomenon of organization is discussed and its consequences for the understanding of human actions and human choices are examined. Affiliation to organizations are found to be both restrictions on and preconditions for most human action. In this connection families are regarded as organizations as well as enterprises, voluntary associations and states. Human action is primarily action on behalf of organizations where individuals are partly human, partly organization. To understand the meaning of action on behalf of organization it is important to realize that people rarely choose their organizational affiliation. People are selected. This means that actions on behalf of organizations cannot be regarded as expressions of individual choices. Actions on behalf of organizations are generally characterized by a dual involvement.Sociologisk Forsknings digitala arkiv</p

Delvis människa, delvis organisation

Partly human, partly organization In this article the phenomenon of organization is discussed and its consequences for the understanding of human actions and human choices are examined. Affiliation to organizations are found to be both restrictions on and preconditions for most human action. In this connection families are regarded as organizations as well as enterprises, voluntary associations and states. Human action is primarily action on behalf of organizations where individuals are partly human, partly organization. To understand the meaning of action on behalf of organization it is important to realize that people rarely choose their organizational affiliation. People are selected. This means that actions on behalf of organizations cannot be regarded as expressions of individual choices. Actions on behalf of organizations are generally characterized by a dual involvement.Sociologisk Forsknings digitala arkiv</p

Delvis människa, delvis organisation

Partly human, partly organization In this article the phenomenon of organization is discussed and its consequences for the understanding of human actions and human choices are examined. Affiliation to organizations are found to be both restrictions on and preconditions for most human action. In this connection families are regarded as organizations as well as enterprises, voluntary associations and states. Human action is primarily action on behalf of organizations where individuals are partly human, partly organization. To understand the meaning of action on behalf of organization it is important to realize that people rarely choose their organizational affiliation. People are selected. This means that actions on behalf of organizations cannot be regarded as expressions of individual choices. Actions on behalf of organizations are generally characterized by a dual involvement.Sociologisk Forsknings digitala arkiv</p

Upptäckten av det globala

Sociologisk Forsknings digitala arkiv</p

Vad hände på åttiotalet?

Sociologisk Forsknings digitala arkiv</p

Sociologisk Forskning för femtio år sedan

Sociologisk Forsknings digitala arkiv</p

Organiseringen av det civila samhället

The organization of civil society The three societal spheres state, market and civil society are compared from an organizational perspective. A state is a certain kind of organization with compulsory affiliation. The state is an empirical category that is fairly easy to describe. A market is made up of the interaction of several organizations in exchange. Most actors on a market are people acting on behalf of organizations. Also states are present in markets buying arms for example, or as employers on the labour market. There are several kinds of organization mentioned in connection with civil society such as voluntary associations, social movements and networks. It is concluded that the organizations of civil society are not very persistent. Moreover the notion of civil society is not more incompatible with the state than with other organizational arrangements. As a conclusion it is argued that it is more relevant to understand social processes in terms of types of organization that in terms of states, markets and civil society.Sociologisk Forsknings digitala arkiv</p

Sociologin kommer igen

Sociologisk Forsknings digitala arkiv</p