5 research outputs found
The impact of viral mutations on recognition by SARS-CoV-2 specific T cells.
- Author
- Aanensen DM
- Abudahab K
- Adams A
- Adams H
- Adeniji K
- Afifi S
- Aggarwal D
- Agranoff D
- Agwuh K
- Ahmad SSY
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- Aigrain L
- Ail D
- Alcolea-Medina A
- Aldera EL
- Alegria A
- Alex B
- Alikhan N-F
- Allara E
- Allen S
- Amato R
- Andrikopoulos P
- Angus B
- Angyal A
- Annett T
- Aplin S
- Ariani CV
- Armstrong JA
- Asad H
- Ash A
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- Asiimwe IG
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- da Silva Filipe A
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- xeine O'Toole
- Xu-McCrae L
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- Zamudio ME
- Zarebski AE
- Zhang JE
- Zhang P
- Publication venue
- iScience
- Publication date
- 01/01/2021
- Field of study
We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of recognition by epitope-specific T cells assessed by IFN-γ and cytotoxic killing assays. Complete loss of T cell responsiveness was seen due to Q213K in the A∗01:01-restricted CD8+ ORF3a epitope FTSDYYQLY207-215; due to P13L, P13S, and P13T in the B∗27:05-restricted CD8+ nucleocapsid epitope QRNAPRITF9-17; and due to T362I and P365S in the A∗03:01/A∗11:01-restricted CD8+ nucleocapsid epitope KTFPPTEPK361-369. CD8+ T cell lines unable to recognize variant epitopes have diverse T cell receptor repertoires. These data demonstrate the potential for T cell evasion and highlight the need for ongoing surveillance for variants capable of escaping T cell as well as humoral immunity.This work is supported by the UK Medical Research Council (MRC); Chinese Academy of Medical Sciences(CAMS) Innovation Fund for Medical Sciences (CIFMS), China; National Institute for Health Research (NIHR)Oxford Biomedical Research Centre, and UK Researchand Innovation (UKRI)/NIHR through the UK Coro-navirus Immunology Consortium (UK-CIC). Sequencing of SARS-CoV-2 samples and collation of data wasundertaken by the COG-UK CONSORTIUM. COG-UK is supported by funding from the Medical ResearchCouncil (MRC) part of UK Research & Innovation (UKRI),the National Institute of Health Research (NIHR),and Genome Research Limited, operating as the Wellcome Sanger Institute. T.I.d.S. is supported by a Well-come Trust Intermediate Clinical Fellowship (110058/Z/15/Z). L.T. is supported by the Wellcome Trust(grant number 205228/Z/16/Z) and by theUniversity of Liverpool Centre for Excellence in Infectious DiseaseResearch (CEIDR). S.D. is funded by an NIHR GlobalResearch Professorship (NIHR300791). L.T. and S.C.M.are also supported by the U.S. Food and Drug Administration Medical Countermeasures Initiative contract75F40120C00085 and the National Institute for Health Research Health Protection Research Unit (HPRU) inEmerging and Zoonotic Infections (NIHR200907) at University of Liverpool inpartnership with Public HealthEngland (PHE), in collaboration with Liverpool School of Tropical Medicine and the University of Oxford.L.T. is based at the University of Liverpool. M.D.P. is funded by the NIHR Sheffield Biomedical ResearchCentre (BRC – IS-BRC-1215-20017). ISARIC4C is supported by the MRC (grant no MC_PC_19059). J.C.K.is a Wellcome Investigator (WT204969/Z/16/Z) and supported by NIHR Oxford Biomedical Research Centreand CIFMS. The views expressed are those of the authors and not necessarily those of the NIHR or MRC
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- Zafar S
- Zakeri R
- Zourob M
- Zuccarrelli A
- Publication venue
- Oxford University Press
- Publication date
- 01/06/2023
- Field of study
Background
Acute pancreatitis is a common, yet complex, emergency surgical presentation. Multiple guidelines exist and management can vary significantly. The aim of this first UK, multicentre, prospective cohort study was to assess the variation in management of acute pancreatitis to guide resource planning and optimize treatment.
Methods
All patients aged greater than or equal to 18 years presenting with acute pancreatitis, as per the Atlanta criteria, from March to April 2021 were eligible for inclusion and followed up for 30 days. Anonymized data were uploaded to a secure electronic database in line with local governance approvals.
Results
A total of 113 hospitals contributed data on 2580 patients, with an equal sex distribution and a mean age of 57 years. The aetiology was gallstones in 50.6 per cent, with idiopathic the next most common (22.4 per cent). In addition to the 7.6 per cent with a diagnosis of chronic pancreatitis, 20.1 per cent of patients had a previous episode of acute pancreatitis. One in 20 patients were classed as having severe pancreatitis, as per the Atlanta criteria. The overall mortality rate was 2.3 per cent at 30 days, but rose to one in three in the severe group. Predictors of death included male sex, increased age, and frailty; previous acute pancreatitis and gallstones as aetiologies were protective. Smoking status and body mass index did not affect death.
Conclusion
Most patients presenting with acute pancreatitis have a mild, self-limiting disease. Rates of patients with idiopathic pancreatitis are high. Recurrent attacks of pancreatitis are common, but are likely to have reduced risk of death on subsequent admissions
Total Productive Maintenance in a Manufacturing Industry: A Case Study of JISHU HOZEN Implementation
- Author
- Publication venue
- 'Indian Society for Education and Environment'
- Publication date
- Field of study
Monoallelic characteristic-bearing heterozygous L1053X in BRCA2 gene among Sudanese women with breast cancer
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- A Antoniou
- A Carreira
- A Carreira
- A Fourati
- A Riahi
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- A Tazzite
- Abdelmohaymin A. Abdalla
- Alsmawal A. Elimam
- AM Elnour
- D Ford
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- E Capriotti
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- Mohamed A. Abdelrahim
- Mohamed Adel Taha
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- Mohamed D. Dafaalla
- Mohamed El-Fatih Moly Eldeen
- Mohamed Elmogtba Mouaweia Mohamed Aabdein
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- Musaab M. Alfaki
- Musab I. Mohammed
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- N Hadiji-Abbes
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- NC Merwe van der
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- SL Anwar
- SS Yuan
- SV Tavtigian
- TA Hall
- TM Friebel
- TR Rebbeck
- Y Miki
- Z Kote-Jarai
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Pancreatic surgery outcomes: multicentre prospective snapshot study in 67 countries
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- Slepavicius A
- Slim S
- Smet B
- Smith A
- Smith M
- Soggiu F
- Soggiu F
- Sohaimee NB
- Solaini L
- Solecki M
- Soliman A
- Soliva R
- Solomonov E
- Sommacale D
- Sonkar AA
- Soon KP
- Sotiropoulou M
- Souadka A
- Souche F-R
- Souliman M
- Spampinato MG
- Spanu A
- Sparrelid E
- Spatayev Z
- Spencer-Cole RT
- Sperti C
- Sreekumar RC
- Srinivasa S
- Sritharan M
- Sritharan M
- Stamopoulos P
- Stamos N
- Stavrou GA
- Stavrou GA
- Steffen T
- Stella M
- Stergiou D
- Sticca R
- Stojanovic M
- Storto GL
- Stoyanova R
- Straka M
- Struecker B
- Strupas K
- Strupas K
- Strypstein S
- Stylianidis S
- Stögerová C
- Subar D
- Sucandy I
- Suhaimi NAB
- Suhaimi NMFB
- Sulaiman AS
- Sulciner M
- Sulimani O
- Sulpice L
- Sulpice L
- Sultana A
- Sumarokova V
- Suresh V
- Suryawanshi P
- Sutcliffe R
- Suárez-Muñoz MÁ
- Swealem A
- Syllaios A
- Szatmary P
- Szewczyk P
- Szwedziak K
- Sánchez-Cabús S
- Sánchez-Velázquez P
- Sędłak K
- Słodkowski M
- Tabeti B
- Taddei A
- Tagar E
- Taha A
- Taha SSO
- Takorov I
- Talib H
- Tamburrino D
- Tamburrino D
- Tammik O
- Tammik O
- Tan JH
- Tanabayeva S
- Tanabe M
- Tanas Y
- Tang E
- Tang E
- Tani M
- Tanyous S
- Tarantino I
- Targarona J
- Tarik B
- Tarkhan Y
- Tayiawi M
- Taylor L
- Taylor M
- Taylor M
- Teh C
- Teixeira UF
- Tekin E
- Tenreiro N
- Tepetes K
- Tesarikova J
- Testa V
- Testini M
- Tez M
- Thakkar R
- The C
- Theab M
- Theab RAK
- Thiruchelvam N
- Thomaidis P
- Thompson R
- Tidjane A
- Tijani EH
- Tilak S
- Tingstedt B
- Tinguely P
- Tinguely P
- Tishreen AH
- Tisone G
- Titi R
- Tobba TM
- Tokarev M
- Tolin F
- Tolis EAN
- Tomara N
- Tomara NK
- Tomazic A
- Tommaso S
- TomአS
- Tonini V
- Tooulias A
- Torab SS
- Torelly L
- Torgomyan G
- Torres O
- Torres OJM
- Torres SM
- Torres-Quevedo R
- Toso C
- Touabti S
- Toutouzas K
- Triantafyllidis I
- Tripathi M
- Trizzino A
- Troci A
- Troisi RI
- Trotovšek B
- TrotovŠek B
- Truant S
- Tsakiris C
- Tsalis K
- Tsaramanidis S
- Tschuor C
- Tsiotos G
- Tsirlis T
- Tsoukalas N
- Tumas J
- Tuvin D
- Tyutyunnik P
- Tzimas G
- Tölgyes T
- Türkoğlu MA
- Tüzüner A
- Uemura K
- Uggeri F
- Ugrekhelidze K
- Uguz A
- Uhl W
- Ulgur HS
- Ullah S
- Unalp OV
- Urciuoli I
- Uzir SSBM
- Uzunoglu FG
- Vaia A
- Vailas M
- Vaishnav D
- Val AR-D
- Valaroutsos A
- Valcarcel AQ
- Valente R
- Valeriia S
- Valladares AM
- Valmorisco MA
- Valverde DP
- Van Dam JL
- Van den Bossche B
- van Eijck CH
- van Laarhoven S
- Vanagas T
- Varshney V
- Vasavada B
- Vaslamatzis M
- Vass D
- Vassiliu P
- Vazquez PG
- Velagala JR
- Velagala JR
- Velenciuc N
- Velázquez PS
- Veneroni L
- Venkatesh NR
- Vennarecci G
- Vera V
- Vereczkei A
- Vezakis A
- Vigia E
- Vilcu M
- Vilhav C
- Vincenti L
- Virk S
- Vishnoi JR
- Viswanathan K
- Vito D
- Vivarelli M
- Vladov N
- Vodyala C
- Vougas V
- Vouros D
- Vrakopoulou GZ
- Waechter FL
- Waffa Z
- Wagner K
- Wahib EM
- Wake R
- Wang H
- Wang J
- Waqar U
- Waqar U
- Wardeh S
- Wardeszkiewicz A
- Wassmer C-H
- Weber M
- Wei A
- Wei K
- Wei K
- Weitz J
- Wellner U
- Welsch T
- Welsh F
- Wen D
- Wennerblom JH
- Wenning AS
- Wicherts D
- Wierzchowski M
- Wikar T
- Williamsson C
- Windsor J
- Winslow E
- Wlazlak M
- Wolfgang C
- Wu CH
- Wu CH
- Wyroślak-Najs J
- Wüllenweber H-P
- Yadav K
- Yadev I
- Yadev I
- Yaghan R
- Yamamoto T
- Yang P-C
- Yassin LMA
- Yassin R
- Yegen C
- Yeo C
- Yesilyurt D
- Yip V
- Yoong B
- Yoong BK
- Younes E
- Younes E
- Young A
- Yousef A
- Youssef A
- Yu M-C
- Zacharakis E
- Zacharoulis D
- Zachiotis M
- Zagainov V
- Zaharie F
- Zahed M
- Zahed MSM
- Zakaria AD
- Zamri FMB
- Zanatta M
- Zanello M
- Zanini N
- Zanus G
- Zanus G
- Zaruba P
- Zawia A
- Zayed A
- Zdujic P
- Zedelj J
- Zeh HJ
- Zentar A
- Zerbi A
- Zidan T
- Zidan T
- Zironda A
- Zitawi A
- Zivanovic M
- Zogopoulos G
- Zonta S
- Zonta S
- Zorrilla CF
- Zozaya G
- Zreqat Q
- Zuhdi Z
- Zuhdy M
- Zygomalas A
- álvarez PM
- çelik M
- çetiindağ Ö
- Çiftci AB
- çoker A
- öfkeli Ö
- özet A
- Šileikis A
- Šlepavičius A
- Štironja I
- Publication venue
- Publication date
- 18/01/2024
- Field of study