A nanocrystal technology: to enhance solubility of poorly water soluble drugs

Most of the recently developed new chemical entities are poorly water soluble and they create major problems during formulation and development of new dosage form and due to poor solubility and poor bioavailability. The drugs belong to BCS class II and class IV has problem of solubility, to overcome the solubility problem nanotechnology is most useful technique. In this review article the main focus on Nanocrystals and various techniques used for preparation of Nanocrystals. Drug nanocrystals consists pure poorly water soluble drugs without any matrix material which means that it is carrier free drug delivery. Nanocrystals technologies have been introduced as advantageous, universal formulation approaches for the BCS class II and IV drugs. Nanocrystals, with greater surface to volume ratio, can effectively increase both the dissolution rate and saturation solubility of active ingredients The Nanocrystals is suitable drug delivery system for all commonly used routes of administration such as oral, IV, SC, and IM and topical application. Nanocrystals can also be incorporated into the tablets, capsules, fast-melts and lyophilized for sterile product applications. There are no of techniques which are used for production including precipitation, milling, high pressure homogenization and combination methods such as Nano-Edge, SmartCrystal and Precipitation-lyophilization-homogenization (PLH) technology

Stock Market Analysis of 10 Different Countries in the Period of Disease COVID-19

Our effort is to analyze the effect of the rampant over the economies of 10 affected nations by studying their stock market values during the COVID-19 episode. We have endowed the nations with their respective stock markets stated in brackets - Brazil(Ibovespa), Canada (S&P/TSX Composite), France (AEX), Germany (DAX 30), India (NIFTY 50), Italy (FTSE MIB), Russia (IMOEX), Spain (IBEX 35), U.K. (FTSE 100), U.S.A. (DOW JONES INDUSTRIAL AVERAGE). We have gathered the indices of stock per country from 2 March to 23rd June, collected from official website of respective stocks. In order to collect data, we had to inculcate the fundamental lessons of Statistics. R-software aided us to plot the curves of stock values providing an ease to master our project. We also formulated a Python 3.7 language program code to solidify analysis on various aspects of economy of the countries and comparison between these aspects

Properties of Electrodeposited CuSCN 2D Layers and Nanowires Influenced by Their Mixed Domain Structure

International audienc

A Nanocrystal Technology: to Enhance Solubility of Poorly Water Soluble Drugs

Most of the recently developed new chemical entities are poorly water soluble and they create major problems during formulation and development of new dosage form and due to poor solubility and poor bioavailability. The drugs belong to BCS class II and class IV has problem of solubility, to overcome the solubility problem nanotechnology is most useful technique. In this review article the main focus on Nanocrystals and various techniques used for preparation of Nanocrystals. Drug nanocrystals consists pure poorly water soluble drugs without any matrix material which means that it is carrier free drug delivery. Nanocrystals technologies have been introduced as advantageous, universal formulation approaches for the BCS class II and IV drugs. Nanocrystals, with greater surface to volume ratio, can effectively increase both the dissolution rate and saturation solubility of active ingredients The Nanocrystals is suitable drug delivery system for all commonly used routes of administration such as oral, IV, SC, and IM and topical application. Nanocrystals can also be incorporated into the tablets, capsules, Fast-melts and lyophilized for sterile product applications. There are no of techniques which are used for production including precipitation, milling, high pressure homogenization and combination methods such as Nano-Edge, SmartCrystal and Precipitation-lyophilization-homogenization (PLH) technology

Thickness dependent electrical and optical properties of nanocrystalline copper sulphide thin films grown by simple chemical route

657-660A Novel chemical bath deposition (CBD) method has been developed to deposit semiconducting nanocrystalline copper sulphide (Cu2S) thin films on ordinary glass substrates with different thicknesses. The deposition bath consists of aqueous copper chloride (CuCl2), ammonia (NH3) and thiourea [SC(NH2)2]. It is found that the deposition parameters significantly influence the quality and the thickness of Cu2S films. The films were uniform and adherent to glass substrates. The deposited films have been characterized by X-ray diffraction (XRD), Scanning electron microscope (SEM), optical absorption and electrical resistivity. The effect of film thickness on the optical, structural and electrical properties has been studied. The shift of 0.46 eV in the optical band gap energy (Eg) and decrease in electrical resistivity from 6.463 10<span style="font-family:Symbol; mso-ascii-font-family:" times="" new="" roman";mso-hansi-font-family:"times="" roman";="" mso-char-type:symbol;mso-symbol-font-family:symbol"="" lang="EN-GB">-2 to 8.973 <span style="font-family:Symbol; mso-ascii-font-family:" times="" new="" roman";mso-hansi-font-family:"times="" roman";="" mso-char-type:symbol;mso-symbol-font-family:symbol"="" lang="EN-GB"> 10-3 Ω-cm and increase in the grain size of Cu2S crystallites from 30 to 250 nm were observed when the film thickness was varied from 130 to 250 nm. </span

Studies on nanocrystalline ZnS thin films prepared by modified chemical bath deposition method

765-768Nanocrystalline zinc sulphide (ZnS) thin films have been grown on glass surface by modified chemical bath deposition method (M-CBD). The optimized preparative parameters including temperature, pH of solution, immersion time, immersion cycles, have been optimized for fine nanocrystalline film growth. As deposited nanocrystalline zinc sulphide (ZnS) thin films have been characterized for the structural, optical and electrical properties using X-ray diffraction (XRD), UV-Vis spectra and dc electrical conductivity by two point probe method