Pencerakinan kajian istilah dan terjemahan BERNAMA Arab ke bahasa Melayu dan Inggeris

Artikel ini membincangkan aspek kajian istilah dan terjemahan yang dilakukan pada BERNAMA Arab ke bahasa Melayu dan juga Inggeris sebagai medan pembelajaran bagi pelajar bidang pengkhususan bahasa dan kesusasteraan Arab masa kini. Objektif kajian ini adalah untuk meneliti ketepatan penggunaan istilah dari BERNAMA Arab ke bahasa Melayu dan Inggeris, di samping menterjemahkan teks BERNAMA Arab dalam semua aspek ke bahasa Melayu dan Inggeris. Artikel ini juga bertujuan untuk memaparkan padanan istilah dari BERNAMA Arab ke istilah bahasa Melayu dan Inggeris. Keseluruhan kajian ini menggunakan kaedah kualitatif dengan mengaplikasi analisis kandungan seperti rujukan bahan ilmiah utama berdasarkan buku, kamus dan jurnal, di samping bahan utama daripada internet melalui tapak web BERNAMA.com dan tapak web lain yang berkaitan dengannya. Dapatan kajian menunjukkan padanan istilah dipadankan mengikut kesesuaian makna dan secara langsung turut memaparkan istilah yang dapat membantu khalayak pembaca memahami istilah yang sering diguna pakai. Selain itu, hasil kajian menunjukkan terdapat perkataan yang mempunyai istilah yang sama dan makna yang sama, gaya bahasa yang membawa maksud yang berlainan serta kata nama khas. Hasil kajian ini diharapkan dapat memberikan impak yang positif dan menyumbang kepada pemugaran pembelajaran bahasa Arab secara maya dengan lebih efektif

Implementation of Unified Power Quality Conditioner Based on Variable Phase Angle Control Method

This paper investigates the power quality problems which occur frequently in power supply and suggests a method to mitigate the power quality problems by the implementation of UPQC. P-Q problems generally concern with voltage sags/swells and harmonic currents. Custom Power (CP) devices that mitigate these power quality problems have gained more attention in the recent decades. UPQC is Designed, modelled and setup experimentally to mitigate voltage sag/swells and harmonic currents in three phase systems. UPQC consists of Dynamic Voltage Restorer (DVR) and Active Power Filter (APF). UPQC with proposed controller algorithms effectively compensates the sag/swell in supply voltage by keeping the load voltage amplitude at 0.9-1 per unit and eliminates the load current harmonics by keeping supply current at 5% less than of Total Harmonic Distortion,simultaneously. Keywords: Custom power device,Voltage sag,swell,Harmonics. DOI: 10.7176/ISDE/12-3-03 Publication date:September 30th 202

The Effect of a Magnetic Field on the Melting of Gallium in a Rectangular Cavity

The role of magnetic field and natural convection on the solid–liquid interface motion, flow, and heat transfer during melting of gallium on a vertical wall is reported in this paper. The classical geometry consisting of a rectangular cavity with uniform but different temperatures imposed at two opposite side walls, insulated top, and bottom walls is considered. The magnetic field is imposed in the horizontal direction. A numerical code is developed to solve for natural convection coupled to solid–liquid phase transition and magnetic effects. The corresponding streamlines and isotherms predicted by the numerical model serve to visualize the complicated flow and temperature field. The interplay between the conduction and convection modes of heat transfer stimulated by the combination of the buoyancy-driven flow and the Lorentz force on the fluid due to the magnetic field are studied. The results show that the increase of Rayleigh number promotes heat transfer by convection, while the increase of Hartmann number dampens the strength of circulating convective currents and the heat transfer is then mainly due to heat conduction. These results are applicable in general to electrically conducting fluids and we show that magnetic field is a vital external control parameter in solid–liquid interface motion

Understanding Livelihoods for Protected Area Management: Insights from Northern Madagascar

Protected areas (PA) are the most common approach to conservation globally; however, their effectiveness is unclear when neighbouring human communities are highly natural resource dependent. While forest-based livelihoods provide important income for rural communities, destructive livelihoods such as charcoal production can also threaten the sustainability of PAs. We aimed to understand drivers of livelihood choices in communities surrounding a proposed PA threatened by charcoal production in northern Madagascar, to inform management strategies that promote forest conservation without negatively impacting local communities. We used semi-structured interviews and focus groups to understand local livelihood dynamics using the Sustainable Livelihoods Framework (SLF). Our findings showed charcoal production to be an important livelihood used to deal with annual food insecurity. Agricultural yields were limited by a lack of assets for clearing land and building protective fences. Households were also hesitant to invest in agriculture due to the perceived risks associated with unpredictable rainfall and cattle grazing. Furthermore, while fishing was an important livelihood for filling income gaps, declining catches due to overexploitation across the study region appeared to be increasing the need for charcoal production. While improvements to agriculture were perceived to be promising strategies for reducing forest-dependence, a landscape approach to conservation in the region will be necessary in order to promote sustainability of all livelihoods and to reduce overall pressures on forest resources

Model-Informed Drug Development:Steps Toward Harmonized Guidance

Global alignment of expectations is required to achieve consistency in the planning, conduct, reporting, and regulatory review of modelinformed drug development (MIDD) applications. An International Council for Harmonization (ICH) MIDD general principles guideline has been positioned to provide a common standard of practice including a framework for risk-based assessment of MIDD-derived evidence within the context of global regulatory decision-making. This perspective provides the background, our viewpoints, and the next steps in the development of this guideline

Systematic evaluation of pembrolizumab dosing in patients with advanced non-small cell lung cancer

International audienceBACKGROUND: In the phase I KEYNOTE-001 study, pembrolizumab demonstrated durable antitumor activity in patients with advanced non-small cell lung cancer (NSCLC). We sought to characterize the relationship between pembrolizumab dose, exposure, and response to define an effective dose for these patients. METHODS: Patients received pembrolizumab 2 mg/kg every 3 weeks (Q3W) (n=55), 10 mg/kg Q3W (n=238), or 10 mg/kg Q2W (n=156). Response (RECIST v1.1) was assessed every 9 weeks. The relationship between the estimated pembrolizumab area under the concentration-time curve at steady-state over 6 weeks (AUCss-6weeks) and the longitudinal change in tumor size (sum of longest diameters) was analyzed by regression and nonlinear mixed effects modeling. This model was simultaneously fit to all tumor size data, then used to simulate response rates, normalizing the trial data across dose for prognostic covariates (tumor PD-L1 expression and EGFR mutation status). The exposure-safety relationship was assessed by logistic regression of pembrolizumab AUCss-6weeks versus occurrence of adverse events of interest based on their immune etiology. RESULTS: Overall response rates were 15% (95% confidence interval [CI] 7%-28%) at 2 Q3W, 25% (18%-33%) at 10 Q3W, and 21% (95% CI 14% to 30%) at 10 Q2W. Regression analyses of percentage change from baseline in tumor size versus AUCss-6week indicated a flat relationship (regression slope P\textgreater0.05). Simulations showed the exposure-response relationship to be similarly flat, thus indicating that the lowest evaluated dose of 2 mg/kg Q3W to likely be at or near the efficacy plateau. Exposure-safety analysis showed the adverse event incidence to be similar among the clinically tested doses. CONCLUSIONS: No significant exposure dependency on efficacy or safety was identified for pembrolizumab across doses of 2 mg/kg to 10 mg/kg. These results support the use of a 2-mg/kg Q3W dosage in patients with previously treated, advanced NSCLC.ClinicalTrials.gov registry: NCT0129582

Compare the quality fish paste production of Kilka (Clupeonella cultriventris) and Silver carp (Hypophthalmichthys molitrix)

Qualitative changes in the fish spread a mixture of minced meat, fish Kilka (Clupeonella cultiventris) and silver carp (Hypophthalmichthys molitrix) in pasteurized. Fish spread of fish products ready for consumption with soft tissue, such as butter is very good in the world market, ready to use paste of fish production due to the variety, taste good, able to use for all ages in the community a special place in the fisheries industry countries are active in the field of fisheries products. The valuable features of this product, it is possible to produce fish midget, cheap, circumstantial fished, farmed fish, waste and waste from the fish processing factories are notably food production of fish protein sources that have the flavor is very suitable for all age groups was the research goals, in order to process the cream edible fillets and minced meat (minced fish) cultured fish silver carp (Hypophthalmichthys molitrix) and fish in the Caspian Sea Kilka (Clupeonella cultriventris) are treated as a combination of four: 1. Silver carp minced meat 100% +30% filler +1% spice, thickeners, improved color, taste 2. Kilka minced meat 100% +30% filler +1% spice, thickeners, improved color, taste 3. Kilka and Silver carp minced meat 50+50 % +30% filler +1% spice, thickeners, improved color, taste 4. Silver carp and Kilka minced meat 75+25 % +30% filler +1% spice, thickeners, improved color, taste 5. Silver carp and Kilka minced meat 25+75 % +30% filler +1% spice, thickeners, improved color, taste. After the initial blanching minced meat (80oc temperature for 3 min) were processed, heat resistant glass samples processed at the full weight of 50 g were, after a hot air steam, capping has been pasteurized for 60 minutes at 80oc, after a hot air steam, capping has been pasteurized for 60 minutes at 80oc and the results show, treatment 100% Silver carp minced fish +30% filler +1% spice, thickeners, improved color, taste better than other treatments and data was significant (P<0.05)

Study of process and quality assessment on hot smoked fish kilka production, determining its shelf life in vacuum and modified atmosphere and conventional packaging

In this study shelflife of whole hot smocked common kilka (Clupeonella cultriventris) fish packed in usual, vacuum and MAP packages and stored 6 weeks at refrigerator and or frozen temperatures was studied. Samples were analysed for TVBN, PV, pH, TBA, and total count, coliforms, clostridia, psychrophile, mold and sensory attributes weekly and monthly respectively. The ratio of Co2, N2 and O2 in the MAP package was 5: 55: 40%. Results indicated that the mixture gases could decline microbial growth and chemical changes during storage. Microbial and chemical changes in control samples were greater than that found for other samples. No significant microbial and chemical changes was observed in frozen samples during 6 weeks storage except for PV . Samples had the same sensory attributes just after production but were changed during storage significantly. Shelflife of samples packed in usual and MAP packages and stored at referigeratore was 21 and 35 days respectively; while it was 3 and 5 months for frozen samples packed in usual and vacuum packages. The conclusion is that packing hot smocked Kilka fish in vacuum and MAP packages can increase shelflife and decrease economical loss due to fish spoilage

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival