Vicisitudes en la infancia en la época de la inmediatez: un aporte psicoanalítico para su abordaje desde la educación física

El presente trabajo tiene lugar en el marco de los desarrollos teórico- clínicos propuestos por la Profesora Titular Lic. María Eugenia Saavedra y el Profesor Adjunto Lic. Ramón Ojeda de las materias Psicología del Ciclo Vital II (Licenciatura en Musicoterapia) y Diagnóstico y Abordaje de las Crisis Infanto Juveniles (Licenciatura en Psicología), de la Facultad de Psicología de la Universidad de Buenos Aires (UBA). La iniciativa para la escritura surge al escuchar en el relato de algunos docentes de Educación Física de nivel inicial, preguntas, inquietudes e incluso quejas que se reiteran y se conforman en dificultades en el momento de dar clases. Entre ellas: lograr que los niños dejen de moverse, hagan silencio y presten atención cuando el docente lo solicita y la actividad planteada lo requiere. Desde el marco teórico del psicoanálisis freudiano-lacaniano proponemos una lectura de estas vicisitudes mencionadas bajo tres aspectos que tienen como vector el tratamiento del tiempo.A number of early childhood Physical Education teachers bring up the difficulty of getting children to stop moving, keep silent and pay attention in class. Considering the theoretical framework of Freudian-Lacanian psychoanalysis, we aim to analyzethe above-mentioned situations from three perspectives, all of which agree on the main focus of this article: the treatment of time.Mesa de trabajos libres: Psicología y EducaciónFacultad de Psicologí

Vicisitudes en la infancia en la época de la inmediatez: un aporte psicoanalítico para su abordaje desde la educación física

El presente trabajo tiene lugar en el marco de los desarrollos teórico- clínicos propuestos por la Profesora Titular Lic. María Eugenia Saavedra y el Profesor Adjunto Lic. Ramón Ojeda de las materias Psicología del Ciclo Vital II (Licenciatura en Musicoterapia) y Diagnóstico y Abordaje de las Crisis Infanto Juveniles (Licenciatura en Psicología), de la Facultad de Psicología de la Universidad de Buenos Aires (UBA). La iniciativa para la escritura surge al escuchar en el relato de algunos docentes de Educación Física de nivel inicial, preguntas, inquietudes e incluso quejas que se reiteran y se conforman en dificultades en el momento de dar clases. Entre ellas: lograr que los niños dejen de moverse, hagan silencio y presten atención cuando el docente lo solicita y la actividad planteada lo requiere. Desde el marco teórico del psicoanálisis freudiano-lacaniano proponemos una lectura de estas vicisitudes mencionadas bajo tres aspectos que tienen como vector el tratamiento del tiempo.A number of early childhood Physical Education teachers bring up the difficulty of getting children to stop moving, keep silent and pay attention in class. Considering the theoretical framework of Freudian-Lacanian psychoanalysis, we aim to analyzethe above-mentioned situations from three perspectives, all of which agree on the main focus of this article: the treatment of time.Mesa de trabajos libres: Psicología y EducaciónFacultad de Psicologí

Treatment of mild malnutrition and reduction of morbidity in major abdominal surgery: randomized trial on 153 patients]

Severe malnutrition (defined as weight loss more than 10% in a period of six months) is considered an important risk factor in major abdominal surgery, because of a higher post-operative mortality and morbidity. The aim of our study is to assess the role of mild malnutrition (weight loss low than 10% in a period of six months) as a risk factor in major abdominal surgery and to evaluate the efficacy of therapy in order to improve outcomes in terms of in-hospital mortality, length of hospital stay and post-operative complications. Moreover, we evaluated serum albuminemia and lymphocyte count, important nutritional index, as predictive risk factors. We performed a randomized prospective trial, and admitted in our institution 153 adult patients, 43 with mild malnutrition and 110 without. The malnourished patients were randomized in two groups: the first one received oral immunonutrition (Impact Oral) for 7-10 days before surgery (22 pz), the second one received no nutritional support. We observed a higher number of complications in the non-treated malnourished patients (57%) versus both the treated malnourished patients (13.6%) and the normal group (19%) (p<0.001). Increased morbidity was observed in patients with serum albuminemia <2.8 gr/dl (69.2%) and with lymphocyte count <1.500 mm3 (57%). Nutritional enriched support demonstrated his efficacy in reducing morbidity, and length of hospital stay. Pre-operative oral immunonutrition might be suggested and established in all the patients with mild malnutrition that will be operated on major abdominal surger

Globular Domain of the Prion Protein Needs to Be Unlocked by Domain Swapping to Support Prion Protein Conversion*

Prion diseases are fatal transmissible neurodegenerative diseases affecting many mammalian species. The normal prion protein (PrP) converts into a pathological aggregated form, PrPSc, which is enriched in the β-sheet structure. Although the high resolution structure of the normal PrP was determined, the structure of the converted form of PrP remains inaccessible to high resolution techniques. To map the PrP conversion process we introduced disulfide bridges into different positions within the globular domain of PrP, tethering selected secondary structure elements. The majority of tethered PrP mutants exhibited increased thermodynamic stability, nevertheless, they converted efficiently. Only the disulfides that tether subdomain B1-H1-B2 to subdomain H2-H3 prevented PrP conversion in vitro and in prion-infected cell cultures. Reduction of disulfides recovered the ability of these mutants to convert, demonstrating that the separation of subdomains is an essential step in conversion. Formation of disulfide-linked proteinase K-resistant dimers in fibrils composed of a pair of single cysteine mutants supports the model based on domain-swapped dimers as the building blocks of prion fibrils. In contrast to previously proposed structural models of PrPSc suggesting conversion of large secondary structural segments, we provide evidence for the conservation of secondary structural elements of the globular domain upon PrP conversion. Previous studies already showed that dimerization is the rate-limiting step in PrP conversion. We show that separation and swapping of subdomains of the globular domain is necessary for conversion. Therefore, we propose that the domain-swapped dimer of PrP precedes amyloid formation and represents a potential target for therapeutic intervention