The Central Correlations of Hypercharge, Isospin, Colour and Chirality in the Standard Model

The correlation of the fractionally represented hypercharge group with the isospin and colour group in the standard model determines as faithfully represented internal group the quotient group {\U(1)\x\SU(2)\x\SU(3)\over\Z_2\x\Z_3}. The discrete cyclic central abelian-nonabelian internal correlation involved is considered with respect to its consequences for the representations by the standard model fields, the electroweak mixing angle and the symmetry breakdown. There exists a further discrete $\Z_2$-correlation between chirality and Lorentz properties and also a continuous \U(1)-external-internal one between hyperisospin and chirality.Comment: 18 pages, latex, macros include

The role of imaging in early hip OA

SummaryHip osteoarthritis (OA) is characterized by cartilage degradation, subchondral bone sclerosis and osteophyte formation. Nowadays, OA is thought to develop via different etiologies that all lead to a similar form of end stage joint degradation. One of these subtypes is related to an abnormal shaped hip joint, like acetabular dysplasia and a cam deformity. These bony abnormalities are highly predictive for development of hip OA, but they are likely to already be present from childhood. This suggests that these deformations induce OA changes in the hip, well before extensive hip degradation becomes present three to four decades later. Accurate detection and successful characterization of these early OA events might lead to better treatment options for hip OA besides nowadays available invasive joint replacement surgery. However, current diagnostic imaging techniques like radiographs or plain magnetic resonance imaging (MRI), are not sensitive enough to detect these subtle early OA changes. Nor are they able to disentangle intertwined and overlapping cascades from different OA subtypes, and neither can they predict OA progression. New and more sensitive imaging techniques might enable us to detect first OA changes on a cellular level, providing us with new opportunities for early intervention. In this respect, shape analysis using radiography, MRI, computed tomography (CT), single photon emission computed tomography (SPECT)/CT, and positron emission tomography (PET) might prove promising techniques and be more suited to detect early pathological changes in the hip joint. A broad application of these techniques might give us more understanding what can be considered physiological adaptation of the hip, or when early OA really starts. With a more clear definition of early OA, more homogenous patient populations can be selected and help with the development of new disease modifying OA interventions

Killing spinors in supergravity with 4-fluxes

We study the spinorial Killing equation of supergravity involving a torsion 3-form \T as well as a flux 4-form \F. In dimension seven, we construct explicit families of compact solutions out of 3-Sasakian geometries, nearly parallel \G_2-geometries and on the homogeneous Aloff-Wallach space. The constraint \F \cdot \Psi = 0 defines a non empty subfamily of solutions. We investigate the constraint \T \cdot \Psi = 0, too, and show that it singles out a very special choice of numerical parameters in the Killing equation, which can also be justified geometrically

On invariants of almost symplectic connections

We study the irreducible decomposition under Sp(2n, R) of the space of torsion tensors of almost symplectic connections. Then a description of all symplectic quadratic invariants of torsion-like tensors is given. When applied to a manifold M with an almost symplectic structure, these instruments give preliminary insight for finding a preferred linear almost symplectic connection on M . We rediscover Ph. Tondeur's Theorem on almost symplectic connections. Properties of torsion of the vectorial kind are deduced

Composition algebras and the two faces of G2G_{2}

We consider composition and division algebras over the real numbers: We note two r\^oles for the group $G_{2}$: as automorphism group of the octonions and as the isotropy group of a generic 3-form in 7 dimensions. We show why they are equivalent, by means of a regular metric. We express in some diagrams the relation between some pertinent groups, most of them related to the octonions. Some applications to physics are also discussed.Comment: 11 pages, 3 figure

Wat kan het buitengebied van Amsterdam betekenen voor de gezondheid van de Amsterdammers

Dit rapport gaat over de betekenis die het buitengebied van Amsterdam heeft voor de gezondheid van Amsterdammers. Van de 1349 agrariërs binnen een straal van 10 kilometer rondom Amsterdam richten er zich 7 op de zorglandbouw, 3 op educatie, 1 op kinderopvang en 49 op recreatie. Het aanbod is onvoldoende en onregelmatig verspreid. Met name op het gebied van zorglandbouw, recreatie, kinderopvang en nieuwe vormen van participatie van burgers in agrarische bedrijven is een aanzienlijke groei mogelijk. Recreatie en zorgtaken kunnen leiden tot een additioneel bedrijfsinkomen van 15.000 euro en daarmee bijdragen aan het instandhouden van landbouwbedrijven en de instandhouding van het open buitengebied

The Satiety Signaling Neuropeptide Perisulfakinin Inhibits the Activity of Central Neurons Promoting General Activity

The metabolic state is one of the determinants of the general activity level. Satiety is related to resting or sleep whereas hunger correlates to wakefulness and activity. The counterpart to the mammalian satiety signal cholecystokinin (CCK) in insects are the sulfakinins. The aim of this study was to resolve the mechanism by which the antifeedant activity of perisulfakinin (PSK) in Periplaneta americana is mediated. We identified the sources of PSK which is used both as hormone and as paracrine messenger. PSK is found in the neurohemal organ of the brain and in nerve endings throughout the central nervous system. To correlate the distributions of PSK and its receptor (PSKR), we cloned the gene coding for PSKR and provide evidence for its expression within the nervous system. It occurs only in a few neurons, among them are the dorsal unpaired median (DUM) neurons which release octopamine thereby regulating the general level of activity. Application of PSK to DUM neurons attenuated the spiking frequency (EC50=11pM) due to reduction of a pacemaker Ca2+ current through cAMP-inhibited pTRPγ channels. PSK increased the intracellular cAMP level while decreasing the intracellular Ca2+ concentration in DUM neurons. Thus, the satiety signal conferred by PSK acts antagonistically to the hunger signal, provided by the adipokinetic hormone (AKH): PSK depresses the electrical activity of DUM neurons by inhibiting the pTRPγ channel that is activated by AKH under conditions of food shortage

Shrouded CMC Rotor Blades for High Pressure Turbine Applications

The density of Ceramic Matrix Compos-ite(CMC) materials is approximately 1/3 the density of metals currently used for High Pressure Turbine(HPT) blades. A lower density, and consequently lower centrifugal stresses, increases the feasibility of shrouding HPT blades. Shrouding HPT blades improves aerodynamic eciency, especially for low aspect ratio turbine blades. This paper explores aerodynamic and structural issues associated with shrouding HPT rotor blades. Detailed Navier-Stokes analysis of a rotor blade showed that shrouding improved blade row aerodynamic eciency by 1.3%, when the clearance was 2% of the blade span. Recessed casings were used. Without a shroud the depth of the recess equaled the clearance. With a shroud the recess depth increased by the shroud thickness, which included a knife seal. There was good agreement between the predicted stage eciency for the unshrouded blades and the experimentally measured efficiency. Structural analysis showed a strong interaction between stresses in the shroud and peak stresses at the hub of the blade. A thin shroud of uniform thickness only moderately increased maximum blade stress, but there were very high stresses in the shroud itself. Increasing shroud thickness reduced stresses in the shroud, but increased blade stresses near the hub. A single knife seal added to the thin shroud noticeably decreased maximum shroud stress, without increasing maximum blade stress. Maximum stresses due to pressure loads and combined pressure and centrifugal loads were nearly the same as the maximum stresses for individual pressure or cen-trifugal loads. Stresses due to a 100K temperatur