Seroprevalence of COVID-19 antibody among patients visiting a large clinic in Uttar Pradesh

Background: The study was conducted to determine the Coronavirus disease 2019 (COVID-19) antibody titre among patients who visited our clinic in Lucknow in order to find out the prevalence of sero positivity and to determine the association between COVID anti-body titre and positivity to different age groups, sex, and religions etc., if any.Methods: Secondary data analysis was conducted at Lucknow's Sitara polyclinic from patients’ data, who had attended the clinic between May 2021 and July 2021 and had universally undergone COVID antibody testing. COVID antibody (including IgG) levels in patients' blood were determined using Roche's commercial "Elecsys Anti-SARS-CoV2-cobas e411,601,602 system.by Roche which measure by Eclia (electro chemilusence immunoassay) quantitatively antibodies (including IgG). Patients with titres less than 1 u/ml were deemed seronegative for anti –SARS COVID-2, while those with titres greater than or equal to 1 u/ml were declared seropositive.Results: The overall rate of seropositivity was 84.8%. Around 84.5% males and 85.1% females were seropositive. Seropositivity was higher among 18 to 60 years of age. But there was no significant relation between mean age and seropositivity. Muslims had slightly higher seropositivity (86.0%) as compared to non-Muslims (84.5%). There was no significant difference between age and gender having positive COVID 19 antibody titres. Although the incidence of seropositivity was similar between Muslims and Non-Muslims, the antibody titres were significantly higher in Muslim patients.Conclusions: In this part of central eastern UP, incidence of seropositivity could already be as high as 85%, which is a pointer toward adequate herd immunity. COVID-19 does not differentiate on the basis of age, gender or religious affiliations. However, Muslims were found to have more antibody titres compared to non-Muslims, possibly related to life style, degree of exposure to COVID-19 virus and presence of inherent immunity

Unique Invariant Point Theorems for Random operators In Hilbert Space

We find unique common random fixed point of two random operators in closed subset of a separable Hilbert space by considering a sequence of measurable functions satisfying  Theorem 1.1 and Theorem 1.2. Keywords: Separable Hilbert space, random operators, common random fixed point

Some Result on fixed point Theorem in Hilbert Space

This paper puts up a result regarding the generalization of the Banach contraction  principle in the Hilbert space, It consist of four rational square terms in the inequality. Further the corollary of Koparde and Wag mode was obtained by considering vanishing values to some constant towards the end of this result. Keywords: Hilbert space, closed subset, Cauchy sequence, Completeness

The Rare Decays \piee, \etaee and \etamumu$ in Chiral Perturbation Theory

We calculate the decay rates for \piee, \etaee and \etamumu in chiral perturbation theory. The linear combination of counterterms necessary to render these amplitudes finite is fixed by the recently measured branching fraction for \etamumu. We find \Br(\piee ) = 7\pm 1\times 10^{-8} and \Br(\etaee )=5\pm 1\times 10^{-9}.Comment: (6 pages, 1 figure available on request, uses harvmac.tex), UCSD/PTH 92-23, CALT-68-180

Effect of thresher drive linkage design on human physiological workload of a pedal operated thresher

Abstract: Pedal operated paddy threshers are widely used in the rice growing countries such as India, Bangladesh, Bhutan, Korea and some African countries.  Thresher-drive linkage plays a vital role in human-machine interaction and workload on the human operator.  The four-bar linkage design used in pedal operated paddy thresher was replaced with four alternative designs of thresher drive-linkages to assess the load application pattern and physiological work load while operating the pedal operated paddy thresher.  The machine was tested with five operators for physiological workload estimation.  The linkage combinations were found to have significant effects at 1% level on the work pulse rate and workload to operators.  Considering the force-displacement relationships and physiological workload on the operators, linkage three was found to be the most promising design with lowest work pulse rate of  45.90 beats min-1 and change in energy expenditure rate of 214.5 W (12.87 kJ min-1).   Keywords: pedal operated thresher, thresher, thresher drive linkage, physiological workloa

Clinical profile of patients with prosthetic heart valve thrombosis undergoing fibrinolytic therapy and NYHA class as a predictor of outcome

Background: Prosthetic heart valve thrombosis (PHVT) is a potentially fatal complication of heart valve replacement with mechanical prostheses mainly due to thrombosis.Aim: The study aimed to evaluate the clinical profile of the patients presenting with PHVT undergoing fibrinolytic therapy and analyzing patients with respect to New York Heart Association (NYHA) functional class on presentation and its association with outcome of fibrinolytic therapy.Settings & design: This was prospective, observational study conducted from June, 2016 to April, 2017. Total 133 patients with prosthetic heart valve thrombosis were included. Materials and methods: Routine blood investigations included complete hemogram, liver and renal function tests. Prothrombin time with INR was done on admission. The diagnosis of PHVT was assessed by fluoroscopy and/or echocardiography (transthoracic/transesophageal). Follow-up at 6 months was scheduled for all patients.Statistical analysis: Parametric values between two groups were performed using the independent sample t-test or chi-square test, as appropriate. Univariate and multivariate logistic regression was used to find out factors associated with outcome.Results: All patients received fibrinolytic therapy in which 108 (81.2%) were treated with streptokinase and 25 (18.8%) were treated with urokinase. On presentation, 48.9% patients were in NYHA class III, 41.4% in NYHA class IV and 9.77% in NYHA class II. Fibrinolytic therapy was successful in 105 patients (78.9%) and it failed in 28 patients (21.1%). Mortality in NYHA class II was 0%, NYHA class III was 4.6% and in NYHA class IV was 23.6%. During 6 months follow up prosthetic heart valve thrombosis recurred in 12 (11.43%) patients.Conclusion: From our single centre experience, fibrinolytic therapy is fairly effective first line therapy for prosthetic heart valve thrombosis and NYHA functional class on presentation can predict the outcome of fibrinolytic therapy

Exploring state-of-the-art advances in targeted nanomedicines for managing acute and chronic inflammatory lung diseases

Diagnosis and treatment of lung diseases pose serious challenges. Currently, diagnostic as well as therapeutic methods show poor efficacy toward drug-resistant bacterial infections, while chemotherapy causes toxicity and nonspecific delivery of drugs. Advanced treatment methods that cure lung-related diseases, by enabling drug bioavailability via nasal passages during mucosal formation, which interferes with drug penetration to targeted sites, are in demand. Nanotechnology confers several advantages. Currently, different nanoparticles, or their combinations, are being used to enhance targeted drug delivery. Nanomedicine, a combination of nanoparticles and therapeutic agents, that delivers drugs to targeted sites increases the bioavailability of drugs at these sites. Thus, nanotechnology is superior to conventional chemotherapeutic strategies. Here, the authors review the latest advancements in nanomedicine-based drug-delivery methods for managing acute and chronic inflammatory lung diseases

A honeypot based network security system

Aspects of the present disclosure relate to a honeypot based network security system (100) and a data processing method (200) thereof. In an aspect, the honeypot-based network security system (100) comprises of: an attacking terminal (102) which sends a source data to the honeypot (104), and a honeypot (104) for acquiring the source data sent by the attacking terminal and comprising of bogus data. The method (200) of data processing on a honeypot-based network security system method comprises of: acquiring (202) a plurality of transmission control protocol (TCP) type source data set that are sent by the attack terminal, simulating (204) a TCP protocol for constructing a TCP feedback data packet which meets the pre-set requirement, and sending (206) the TCP feedback data packet to the attack terminal