Minimization of Latency and Power for Network-on-Chip

Network-on-chip (NoC) has emerged as a imperative aspect that determines the performance and power consumption of many-core systems. This paper proposes a combination scheme for NoCs, which aims at gaining low latency and low power consumption. In the presented combination scheme, a peculiar switching mechanism, called virtual circuit switching, is proposed to interweave with circuit switching and packet switching. Flits traveling in virtual circuit switching can pass through the router with only one stage. In addition, multiple virtual circuit-switched (VCS) connections are granted to share a common physical channel. Moreover, a path allocation algorithm is used in this paper to determine VCS connections and circuit-switched connections on a mesh-connected NoC, such that both communication latency and power are optimized. DOI: 10.17762/ijritcc2321-8169.15022

Purification of Mixed State with Closed Timelike Curve is not Possible

In ordinary quantum theory any mixed state can be purified in an enlarged Hilbert space by bringing an ancillary system. The purified state does not depend on the state of any extraneous system with which the mixed state is going to interact and on the physical interaction. Here, we prove that it is not possible to purify a mixed state that traverses a closed time like curve (CTC) and allowed to interact in a consistent way with a causality-respecting (CR) quantum system in the same manner. Thus, in general for arbitrary interactions between CR and CTC systems there is no universal 'Church of the larger Hilbert space' for mixed states with CTC. This shows that in quantum theory with CTCs there can exist 'proper' and 'improper' mixtures.Comment: Latex2e, No Figs, 4 + pages, An error corrected, Results unchange

Basic Logic Gates in Two Dimensional Photonic Crystals for All Optical Device Design

The research carried out in the field of optics and photonics with an idea to design and develop the all optical logic devices in the fascinating material known as photonic crystals (PhCs). The structural investigation reveals that the two dimensional (2-D) PhCs is more suitable for fabrication of optoelectronic components. In this article we have designed basic logic gates in 2-D PhCs as they are the building blocks for the construction of optical devices and in these, refractive index is periodically modulated with the wavelength. The understanding of light behaviour in complex PhCs helps in creating photonic band gap (PBG) that can prevent light of certain wavelength propagating in crystal lattice structure. For the selected geometry structure, three PBG bands will exists out of which two of them are transverse electric (TE) and one is transverse magnetic (TM) mode. The PBG bands in the TE mode ranges from 0.31(a/λ) to 0.46(a/λ) , 0.61(a/λ) to 0.63(a/λ) and TM mode ranges from 0.86(a/λ) to 0.93(a/λ). The free space wavelength of 1550 nm is set for the finite difference time domain (FDTD) simulation of the structure. The response time and computational overhead required for the proposed OR gate is 0.128ps and 4.4MB is obtained. Also we calculated the extinction ratio for AND gate and NOT gate as 6.19 dB and 10.21 dB respectively

Relativistic Mean Field Model parameterizations in the light of GW170817, GW190814, and PSR J0740 + 6620

Three parameterizations DOPS1, DOPS2, and DOPS3 (named after the Department of Physics Shimla) of the Relativistic Mean Field (RMF) model have been proposed with the inclusion of all possible self and mixed interactions between the scalar-isoscalar (\sigma), vector-isoscalar (\omega) and vector-isovector (\rho) mesons up to quartic order. The generated parameter sets are in harmony with the finite and bulk nuclear matter properties. A set of Equations of State (EOSs) composed of pure hadronic (nucleonic) matter and nucleonic with quark matter (hybrid EOSs) for superdense hadron-quark matter in \beta-equilibrium is obtained. The quark matter phase is calculated by using the three-flavor Nambu-Jona-Lasinio (NJL) model. The maximum mass of a non-rotating neutron star with DOPS1 parameterization is found to be around 2.6 M$\odot$ for the pure nucleonic matter which satisfies the recent gravitational wave analysis of GW190814 Abbott et al.,(2020) with possible maximum mass constraint indicating that the secondary component of GW190814 could be a non-rotating heaviest neutron star composed of pure nucleonic matter. EOSs computed with the DOPS2 and DOPS3 parameterizations satisfy the X-Ray observational data and the recent observations of GW170817 maximum mass constraint of a stable non-rotating neutron star in the range 2.01 \pm 0.04 - 2.16 \pm 0.03 M\odot and also in good agreement with constraints on mass and radius measurement for PSR J0740+6620 (NICER) Riley et al., L27 (2021)}, Miller et al., (2021). The hybrid EOSs obtained with the NJL model also satisfy astrophysical constraints on the maximum mass of a neutron star from PSR J1614-2230 and Demorest et al., (2010) .We also present the results for dimensionless tidal deformability, ${\Lambda}$ which are consistent with the waveform models analysis of GW170817.Comment: 14 Pages, 10 Figures. arXiv admin note: text overlap with arXiv:2110.07877 by other author

Observational constraint from the heaviest pulsar PSR J0952-0607 on the equation of state of dense matter in relativistic mean field model

In the present work, we constrain the equation of the state of dense matter in the context of heaviest observed neutron star mass M$_{max}$ = 2.35$\pm 0.17$ M$_{\odot}$ for the black widow pulsar PSR J0952-0607. We propose three interactions HPU1, HPU2 and HPU3 (named after Himachal Pradesh University)for the relativistic mean field model which include different combinations of non-linear, self and cross-couplings among isoscalar-scalar $\sigma$, isoscalar-vector $\omega$ and isovector-vector $\rho$ meson fields up to the quartic order. These interactions are in harmony with the finite nuclei and bulk nuclear matter properties. The equations of state computed by using newly generated interactions for the $\beta$-equilibrated nucleonic matter satisfy the heaviest observed neutron star mass M$_{max}$ = 2.35$\pm 0.17$ M$_{\odot}$ for the black widow pulsar PSR J0952-0607. The results for the radius ($R_{1.4}$) and dimensionless tidal deformability (${\Lambda_{1.4}}$) corresponding to the canonical mass are also presented and agree well with the GW170817 event and astrophysical observations. The radius of $2.08M_{\odot}$ neutron star mass is predicted to be in the range $R_{2.08}$ = 12.98 -13.09 Km which also satisfies the NICER observations by Miller et al. (2021) and Riley et al.(2021). A covariance analysis is also performed to assess the theoretical uncertainties of model parameters and to determine their correlations with nuclear matter observables.Comment: 19 pages, 12 Figures. arXiv admin note: substantial text overlap with arXiv:2305.06667, arXiv:2305.0593

Skeletal Muscle MicroRNA and Messenger RNA Profiling in Cofilin-2 Deficient Mice Reveals Cell Cycle Dysregulation Hindering Muscle Regeneration

Congenital myopathies are rare skeletal muscle diseases presenting in early age with hypotonia and weakness often linked to a genetic defect. Mutations in the gene for cofilin-2 (CFL2) have been identified in several families as a cause of congenital myopathy with nemaline bodies and cores. Here we explore the global messenger and microRNA expression patterns in quadriceps muscle samples from cofillin-2-null mice and compare them with sibling-matched wild-type mice to determine the molecular pathways and mechanisms involved. Cell cycle processes are markedly dysregulated, with altered expression of genes involved in mitotic spindle formation, and evidence of loss of cell cycle checkpoint regulation. Importantly, alterations in cell cycle, apoptosis and proliferation pathways are present in both mRNA and miRNA expression patterns. Specifically, p21 transcript levels were increased, and the expression of p21 targets, such as cyclin D and cyclin E, was decreased. We therefore hypothesize that deficiency of cofilin-2 is associated with interruption of the cell cycle at several checkpoints, hindering muscle regeneration. Identification of these pathways is an important step towards developing appropriate therapies against various congenital myopathies

Pressure Overload in Mice With Haploinsufficiency of Striated Preferentially Expressed Gene Leads to Decompensated Heart Failure

Striated preferentially expressed gene (Speg) is a member of the myosin light chain kinase family of proteins. Constitutive Speg deficient (Speg(-/-)) mice develop a dilated cardiomyopathy, and the majority of these mice die in utero or shortly after birth. In the present study we assessed the importance of Speg in adult mice. Speg(-/-) mice that survived to adulthood, or adult striated muscle-specific Speg knockout mice (Speg-KO), demonstrated cardiac dysfunction and evidence of increased left ventricular (LV) internal diameter and heart to body weight ratio. To determine whether heterozygosity of Speg interferes with the response of the heart to pathophysiologic stress, Speg(+/-) mice were exposed to pressure overload induced by transverse aortic constriction (TAC). At baseline, Speg(+/+) and Speg(+/-) hearts showed no difference in cardiac function. However, 4 weeks after TAC, Speg(+/-) mice had a marked reduction in LV function. This defect was associated with an increase in LV internal diameter and enhanced heart weight to body weight ratio, compared with Speg(+/+) mice after TAC. The response of Speg(+/-) mice to pressure overload also included increased fibrotic deposition in the myocardium, disruption of transverse tubules, and attenuation in cell contractility, compared with Speg(+/+) mice. Taken together, these data demonstrate that Speg is necessary for normal cardiac function and is involved in the complex adaptation of the heart in response to TAC. Haploinsufficiency of Speg results in decompensated heart failure when exposed to pressure overload

Leptoquark Contribution to the Higgs Boson Production at the LHC Collider

In this report we study how a light-scalar leptoquark could affect the Higgs boson production cross-section at the LHC collider. We construct the most general renormalizable and gauge invariant effective Lagrangian involving the standard model particles and a scalar, isoscalar leptoquark, \eta. The total cross-section for pp -> H+X is then calculated for different values of the unknown parameters \lambda_eta, m_eta and m_H.(Here \lambda_eta is the coupling associated with the Higgs-leptoquark interaction.) We find that if \lambda_eta is moderately large and m_eta is around a few hundred GeV, then the cross-section is significantly larger than the standard model value.Comment: 9 pages, 4 postscript figure

Clinical heterogeneity associated with KCNA1 mutations include cataplexy and nonataxic presentations

Mutations in the KCNA1 gene are known to cause episodic ataxia/myokymia syndrome type 1 (EA1). Here, we describe two families with unique presentations who were enrolled in an IRB-approved study, extensively phenotyped, and whole exome sequencing (WES) performed. Family 1 had a diagnosis of isolated cataplexy triggered by sudden physical exertion in multiple affected individuals with heterogeneous neurological findings. All enrolled affected members carried a KCNA1 c.941T>C (p.I314T) mutation. Family 2 had an 8-year-old patient with muscle spasms with rigidity for whom WES revealed a previously reported heterozygous missense mutation in KCNA1 c.677C>G (p.T226R), confirming the diagnosis of EA1 without ataxia. WES identified variants in KCNA1 that explain both phenotypes expanding the phenotypic spectrum of diseases associated with mutations of this gene. KCNA1 mutations should be considered in patients of all ages with episodic neurological phenotypes, even when ataxia is not present. This is an example of the power of genomic approaches to identify pathogenic mutations in unsuspected genes responsible for heterogeneous diseases

Cofilin-2 Phosphorylation and Sequestration in Myocardial Aggregates Novel Pathogenetic Mechanisms for Idiopathic Dilated Cardiomyopathy

AbstractBackgroundRecently, tangles and plaque-like aggregates have been identified in certain cases of dilated cardiomyopathy (DCM), traditionally labeled idiopathic (iDCM), where there is no specific diagnostic test or targeted therapy. This suggests a potential underlying cause for some of the iDCM cases.ObjectivesThis study sought to identify the make-up of myocardial aggregates to understand the molecular mechanisms of these cases of DCM; this strategy has been central to understanding Alzheimer’s disease.MethodsAggregates were extracted from human iDCM samples with high congophilic reactivity (an indication of plaque presence), and the findings were validated in a larger cohort of samples. We tested the expression, distribution, and activity of cofilin in human tissue and generated a cardiac-specific knockout mouse model to investigate the functional impact of the human findings. We also modeled cofilin inactivity in vitro by using pharmacological and genetic gain- and loss-of-function approaches.ResultsAggregates in human myocardium were enriched for cofilin-2, an actin-depolymerizing protein known to participate in neurodegenerative diseases and nemaline myopathy. Cofilin-2 was predominantly phosphorylated, rendering it inactive. Cardiac-specific haploinsufficiency of cofilin-2 in mice recapitulated the human disease’s morphological, functional, and structural phenotype. Pharmacological stimulation of cofilin-2 phosphorylation and genetic overexpression of the phosphomimetic protein promoted the accumulation of “stress-like” fibers and severely impaired cardiomyocyte contractility.ConclusionsOur study provides the first biochemical characterization of prefibrillar myocardial aggregates in humans and the first report to link cofilin-2 to cardiomyopathy. The findings suggest a common pathogenetic mechanism connecting certain iDCMs and other chronic degenerative diseases, laying the groundwork for new therapeutic strategies