Brain muscarinic cholinergic receptors in Huntington's disease

Muscarinic cholinergic receptors and choline acetyltransferase (ChAT) activity were studied in postmortem brain tissue from patients with Huntington's disease and matched control subjects. In comparison with controls, reductions in ChAT activity were found in the hippocampus, but not in the temporal cortex in Huntington's disease. Patients with Huntington's disease showed reduced densities of the total number of muscarinic receptors and of M-2 receptors in the hippocampus while the density of M-1 receptors was unaltered. Muscarinic receptor binding was unchanged in the temporal cortex. These results indicate a degeneration in Huntington's disease of the septo-hippocampal cholinergic pathway, but no impairment of the innominato-cortical cholinergic system

IMPLEMENTASI PENGEMBANGAN SDM PADA KINERJA KARYAWAN PENJUALAN PT AKUSARA KABUPATEN GROBOGAN

Human resource development is the most important factor for a company that is used to increase employee performance productivity and expand employee capacity. This research aims to analyze and find out the implementation of human resource development on the performance of sales employees at PT Akusara. Research methods use qualitative methods by conducting interviews with objects to obtain the necessary information and data. The results of this research show that the Human Resource Development that has been implemented at Akusara PT is by performing 3 techniques namely Needs Analysis, Program Design and Evaluation. The research results to refer to the perspective of the research object are sales employees with a working time of less than 1 year and sales workers with working time over 1 year. Where both explain that with the development of human resources this can develop the ability of sales employees in particular in achieving the sales targets set by the company

MDR-TB is in town; and might be tugging along XDR-TB

No Abstrac

Les performances des maisons d' opéra : une explication statistique

In this paper we try to explain opera houses performances in terms of financial autonomy and occupancy rate. In order to do that, we propose quantifications of variables representing artistic policy, production policy and main environmental components such as theater size, intensity of competition, economic conditions and strength and duration of local lyric tradition. The statistical analysis is done on a sample of 62 opera houses. It shows that environmental factors play the central role in the explanation of performances. In particular, houses that are the less constraint by local lyric tradition display the best performances. Two cases illustrate these conclusions: the Los Angeles Opera and the Berlin Staatsoper.Opera house management; Performance criteria; Financial autonomy; Occupancy rate; Lyric tradition; Historical explanation of performance

KOMPETENSI GURU DALAM PERSPEKTIF AL-QUR’AN (TAFSIR SURAH AL-BAQARAH AYAT 67-71)

ABSTRAK Guru merupakan salah satu komponen penting dalam proses pembelajaran di kelas. Guru bukan hanya bisa mengajar dan menyampaikan ilmunya, namun guru juga dituntut untuk mempunyai kompetensi. Kompetensi guru merupakan seperangkat pengetahuan, keterampilan dan perilaku yang harus dimiliki, dihayati, dikuasai dan diaktualisasikan oleh seorang guru dalam melaksanakan tugas keprofesionalannya. Kajian ini dilatarbelakangi oleh masalah-masalah pendidikan yang terjadi khususnya di Indonesia, yang salah satunya tertuju pada seorang guru. Guru menduduki posisi sebagai penyampai informasi dan mengembangkan karakter, karena ia yang melakukan interaksi langsung dengan peserta didik. Disinilah kualitas pendidikan terbentuk berbanding lurus dengan kualitas pembelajaran yang dilaksanakan oleh kualitas seorang guru. Ditambah adanya pandangan bahwa siapapun bisa menjadi guru asalkan ia berpengetahuan serta kekurangan guru di daerah terpencil, ini memberikan peluang untuk mengangkat seseorang yang kurang mempunyai kompetensi untuk menjadi guru. Adapun rumusan masalah yang dimaksud oleh penulis yaitu; Bagaimana Kompetensi guru dalam prespektif al-Qur’an Surah al-Baqarah ayat 67-71. Dengan tujuan penulis dapat mengetahui tentang kompetensi-kompetensi guru dalam prespektif al- Qur’an Surah al-Baqarah ayat 67-71 tersebut. Penelitian ini merupakan penelitian yang bersifat kualitatif deskriptif, yaitu metode penelitian yang berusaha menggambarkan dan menginterpretasi objek sesuai dengan apa adanya. Tujuannya adalah menggambarkan secara sistematis dan karakteristik objek yang diteliti secara tepat. Jika dilihat dari jenis penelitian, penelitian ini merupakan jenis penelitian kajian pustaka (Library Research). Peneliti menggunakan dua kitab tafsir dengan mengkomparasikan tafsir al-Misbah dan al-Azhar yang diharapakan dapat memperluas dan memperdalam pemahaman tentang redaksi ayat yang hendak diteiti. Setelah dilakukan kajian secara mendalam, hasil dari penelitian ini menunjukkan bahwa kompetensi guru menurut al-Qur’an surah al- Baqarah ayat 67-71 yaitu; guru hendaknya memiliki beberapa kompetensi, diantaranya memiliki kesabaran dalam mengajar (kompetensi kepribadian), kejujuran guru (kompetensi kepribadian), penguasaan materi (kompetensi profesional) mengetahui karakter peserta didik (kompetensi pedagogik), kecakapan dalam berkomunikasi (kompetensi sosial). Kata kunci : Kompetensi Guru, al-Qur’an, Al-Baqarah ayat 67-7

Making contested futures: a politics of designing with people

This PhD research explores how collaborative relationships and capacities for critical knowledge making emerge and are formed through embedded, situated design with people. It focuses especially on designing in the context of working for social and political change. I conducted the project as an embedded designer-researcher with Critical Resistance (CR), a US-based grassroots organization seeking to end reliance on the interconnected systems of prisons, policing, surveillance, and other mechanisms for control and confinement. Reflecting on over two years of work with CR members, the research proposes the importance of attention to the dynamic situatedness of being a designer working with others in participatory and collaborative design, and to the specific contexts that inform and are created through such work. This research builds on scholarship in Participatory Design, Service Design, and feminist and critical epistemology that emphasizes the value of collaborative identification of concerns and possibilities at multiple scales and also explores questions of power, position, and the socio-material and political nature of working with groups to make things and ideas. I suggest that collaborative relationships created through an ongoing practice of doing work together, and a designer’s capacities to be present for it, are a critical component of shaping and understanding participatory practices and what they can generate. In my practice with CR, what we designed together both produced, and was made possible by, how we created ways of working together over time. My capacities and position as a designer in relationship to members’ work were determined by what was of use to the organizing, and through the means we made for sharing ideas, strategies, and goals. In this doctoral submission I argue for an approach to practice that prioritizes what I call “design co-authorship” in which collaborators shape both the contexts for designing and what is designed in the process of creating a shared practice. This requires a deep and explicit engagement by all participants with the dynamic mess of collaboration, including attention to the contradictions, differences, and open questions that emerge and become part of designing together. Working in such a shared practice is, ultimately, a way of creating not just artifacts, systems, or services, but collective knowing and action. Through these ontological and epistemological arguments, I assert that it is the relationships participants create and the knowledge made through them that come to define how designing matters in participatory and collaborative design

Intrasellar rupture of a paraclinoid aneurysm with subarachnoid hemorrhage: usefulness of MR imaging in diagnosis

Characterization of paraclinoid aneurysms may be difficult because of the complexity of anatomic structures involved, and differentiation between intradural and extradural lesions is crucial. We report a case of a patient with a unique presentation of a paraclinoid aneurysm with intrasellar hemorrhage in which the presence of intrasellar blood and the relationship of the paraclinoid aneurysmal neck and sac to the dural rings were elegantly demonstrated on MR imaging and were critical in choosing the target lesion for treatment

Изучение адсорбции технеция-99м на оксиде алюминия из среды метилэтилкетона в статических и динамических условиях

Исследована адсорбция экстрагированного метилэтилкетоном 99mТс на гамма-оксиде алюминия с различной рН-формой в статических и динамических условиях проведения процесса. Определены коэффициенты распределения 99mТс в системе метилэтилкетон - 99mТс - оксид алюминия. Установлено, что максимальная сорбционная емкость по радионуклиду достигается на оксидах с рН-формой 4,5_6. В этих же условиях наблюдаются наименьшие потери 99mТс при проведении его адсорбции на хроматографической колонке и промывке колонки водой, а также наибольший выход 99mТс (более 95 %) при последующем его выделении в виде раствора натрия пертехнетата,99mТс. Показано, что общая продолжительность процесса отделения 99mТс от экстрагента не превышает 20 мин, что сопоставимо с временем получения элюата 99mТс из традиционных сорбционных генераторов, и, в конечном итоге, обеспечивает возможность создания ресурсоэффективных экологически чистых производств радиофармпрепаратов 99mТс

Correction: A Guideline and Checklist for Initiating and Managing Clozapine Treatment in Patients with Treatment-Resistant Schizophrenia

This article was published online on June 27, 2022. An error was subsequently identified in the article, and the following correction should be noted: In the original publication, section 4.6, page 667, the reference cited in the first full sentence in column 2 and in Table 5 on the same page that read: “This information can be used to optimize clozapine dosage (Table 5) [103].” “Table 5 Therapeutic drug monitoring (TDM)-informed decision-making algorithm for clozapine-treated patientsa [103]” “Adapted by permission from reference [103]” Should read: “This information can be used to optimize clozapine dosage (Table 5) [104].” “Table 5 Therapeutic drug monitoring (TDM)-informed decision-making algorithm for clozapine-treated patientsa [104]” “Adapted by permission from reference [104]” The original article has been corrected. © The Author(s) 2022