Comparison of Nuclear and Explosive Destruct Concepts for Nuclear Rocket Engines

Nuclear and explosive destruct concepts for nuclear rocket engine

Dose calculation models for re-entering nuclear rocket debris

Mathematical models of biological hazards from nuclear rocket engine flight failure

Sistema di adattamento automatico di applicazioni interattive desktop per dispositivi mobili

Il lavoro di tesi presenta un sistema, basato su un proxy server, per l'adattamento automatico di pagine web all'accesso tramite dispositivi mobili. Il sistema esegue il processo di trasformazione prendendo in considerazione la descrizione logica delle pagine ed il costo in termini di spazio occupato dagli elementi che compongono l’interfaccia utente (testo, immagini, bottoni, ecc)

High-efficiency production of 5-hydroxyectoine using metabolically engineered Corynebacterium glutamicum

Background: Extremolytes enable microbes to withstand even the most extreme conditions in nature. Due to their unique protective properties, the small organic molecules, more and more, become high-value active ingredients for the cosmetics and the pharmaceutical industries. While ectoine, the industrial extremolyte fagship, has been successfully commercialized before, an economically viable route to its highly interesting derivative 5-hydroxyectoine (hydroxyectoine) is not existing. Results: Here, we demonstrate high-level hydroxyectoine production, using metabolically engineered strains of C. glutamicum that express a codon-optimized, heterologous ectD gene, encoding for ectoine hydroxylase, to convert supplemented ectoine in the presence of sucrose as growth substrate into the desired derivative. Fourteen out of sixteen codon-optimized ectD variants from phylogenetically diverse bacterial and archaeal donors enabled hydroxyectoine production, showing the strategy to work almost regardless of the origin of the gene. The genes from Pseudomonas stutzeri (PST) and Mycobacterium smegmatis (MSM) worked best and enabled hydroxyectoine production up to 97% yield. Metabolic analyses revealed high enrichment of the ectoines inside the cells, which, inter alia, reduced the synthesis of other compatible solutes, including proline and trehalose. After further optimization, C. glutamicum Ptuf ectDPST achieved a titre of 74 g L−1 hydroxyectoine at 70% selectivity within 12 h, using a simple batch process. In a two-step procedure, hydroxyectoine production from ectoine, previously synthesized fermentatively with C. glutamicum ectABCopt, was successfully achieved without intermediate purifcation. Conclusions: C. glutamicum is a well-known and industrially proven host, allowing the synthesis of commercial products with granted GRAS status, a great beneft for a safe production of hydroxyectoine as active ingredient for cosmetic and pharmaceutical applications. Because ectoine is already available at commercial scale, its use as precursor appears straightforward. In the future, two-step processes might provide hydroxyectoine de novo from sugar

Mapping the field of military nursing research 1990–2013: A bibliometric review

BACKGROUND: Over the past 20 years, military forces worldwide have been engaged in a number of conflicts and humanitarian operations and the impact of this on the field of military nursing research is unknown. The aim of this bibliometric review was to investigate the research field of military nursing in the main databases with the purpose to describe trends in military nursing research since 1990. OBJECTIVES: To identify military nursing papers in the main databases and to describe the field of military nursing research for the period 1990–2013 in terms of research productivity, trends in topic focus, trends in authorship and country of publication. METHOD: Bibliometric review of published military nursing research papers was undertaken in March 2014 and data was extracted and coded and trends were analyzed using SPSSv21. RESULTS: In total 237 articles were included in the review. The majority of publications emanating from America (n = 175, 73.8%) and the quantity of papers has increased significantly since the commencement of the second Gulf War in Iraq from 2003 onwards (n = 156, 65.8%). This has been accompanied by a shift in topic focus from professional (n = 16, 20.3%) and occupational issues (n = 17, 21.5%) pre 2003, to clinical (n = 48, 30.4%) and an increase in multidisciplinary research from 4% in 1990–94 to 29% in 2010–13. The mean citations were 10.6 (sd 17.0) and the mean references per paper post 2003 showed a marked increase from 23.5 to 25.4. CONCLUSION: The military nursing research field appears stronger than it has been in the past twenty years and has demonstrated increased transferability to other fields. To maintain this momentum and further develop the field of military nursing research, military forces worldwide need to devise focused nursing research strategies that involve international and multidisciplinary collaboration.Department of HE and Training approved lis

Mechanisms of Ensemble Face Processing: Extraction of Summary, but not Single, Identity Shows Sensitivity to Non-Frontal Global Viewpoints

The recognition and perception of faces – both alone and in groups – is an important biological function, enabling humans to effectively engage with one another socially. This thesis describes viewpoint and identity interactions in processing face ensembles, helping vision scientists to understand the cognitive mechanisms taking place. I manipulated viewpoint or identity across two experiments. The first experiment had participants report an average or single viewpoint or identity, and the second experiment had participants report an average identity or a single identity across a wide range of viewpoints. I find that efficiency in average – but not single – identity extraction decreases as viewpoints are progressively non-frontal. Viewers also extract summary viewpoint better than a single viewpoint, and this ability also decreases as global viewpoints are non-frontal. The implications in the face ensemble processing system, general ensemble processing models, and future research are discussed below.M.A

LOSS-OF-PRESSURE ACCIDENT. HOT LEG PIPING FAILURE

Results are presented of a study to determine if a circumferential rupture in the EGCR hot-leg piping just downstream of the block valve, accompanied by complete lateral displacement of the pipe ends such that the exhaust flows do not oppose each other, will result in excessive pressure differentials across the reactor core. Conclusions and recommendations are included. (J.R.D.

Canticum Canticorum Salomonis

Marca tip. en port. y al finAnot. ms.: "Hallelo en un librero de Córdoba y comprolo ya el Colegio de Sevilla por parecer del padre Francisco de Quesada, Provincial. Juan de Pineda"Enc. Perg.Sign.: a-z4, A

Practical tools to identify short children born small-for-gestational-age eligible for rhGH treatment according to Italian regulation

Recombinant human growth hormone (rhGH) is an approved and effective treatment for short children born small for gestational age (SGA). Prevalence of children eligible for treatment as SGA is reported to be 1:1800. The latest data from the National Registry of Growth Hormone therapy (RNAOC) showed that the number of children treated with SGA indication is still small (prevalence 0.37/100,000) and these children are significantly less reported than those treated for growth hormone deficiency (GHD), although GHD prevalence is 1:4000-1:10,000. This means that many short children born SGA are still not properly identified, and therefore not treated with rhGH, or misdiagnosed as GHD. This article provides some practical tools for the identification of children eligible for rhGH treatment