Unlocking the Impact of Climate Change Mitigation Policies: A Comprehensive Study of Clean and Dirty Innovation Dynamics

Achieving the Paris Climate Agreement’s goal of limiting global warming to 1.5 °C to 2 °C by the end of the century will require massive investments in environmental technologies and a drastic shift away from high-carbon technologies. This paper investigates the impact of climate change mitigation policies on clean energy innovation. A statistical evaluation of the impact of public policies on the rate and direction of innovation for a lowcarbon future is complicated by the nature of the data and the absence of benchmarks. In addition, the statistical analysis is further complicated by the spillover effects between clean and dirty innovation and by the lag effects. In this paper, the authors assess the effects of both public policies, such as carbon taxes and green subsidies, and economic and environmental conditions, such as oil prices, large recessions, climate-related disasters, etc., on clean innovation using a nonparametric method based on the copula distribution of clean innovation. The authors collect data from the European Patent Office (EPO) Worldwide Patent Statistical (PATSTAT) Database, both on clean and dirty patents. This database is managed by the EPO and compiles data from patent offices around the world. The emphasis is put on inventions for which a patent application has been submitted to the United States Patent and Trademark Office (USPTO). The inventions are dated based on the date of their first patent application. Clean innovation refers to patents in areas such as renewable energy generation and electric vehicles, while dirty innovation refers to fossil-based energy generation and internal combustion engines. The authors employ a novel nonparametric test against pairwise differences, especially in tail dependence structures, which we measure with tail copulas, thereby avoiding the possibility of parametric misspecification. This method also permits to examine the effects of various interventions and economic conditions on different portions of the distribution, with a particular emphasis on tail dependence. The authors identify nonlinear dependence structures between clean innovation, public policies, and economic determinants like the oil price and recession. By comparing the effects of clean and dirty innovation, we can determine whether the effect on clean innovation is distinct. The findings indicate that the tightening of environmental policies since the early 1990s has statistically and economically contributed to the increase in clean innovation. The findings can bolster public support for green R&D. In addition, they suggest that green policies may be able to increase the knowledge diffusion of clean innovation

Plasmacytoma of the Nasolacrimal Duct Simulating Dacryocystitis: An Uncommon Presentation for Extramedullary Relapse of Multiple Myeloma

The most common site for localized forms of plasma cell neoplasms (extramedullary plasmacytoma; EMP) is the upper respiratory tract, including the oropharynx, nasal cavities, sinuses and larynx. A 50-year-old woman with a history of myeloma in complete remission after autologous stem cell transplantation complained of two weeks of epiphora of the left eye with subsequent diplopia, bloody nasal discharge and progressive swelling around the nasolacrimal sac. A solitary mass in the left sinonasal area, extending to the nasolacrimal duct (NLD) was detected on MRI, whose histopathological examination was consistent with plasmacytoma. Further clinical investigation ruled out multiple myeloma (MM). The patient underwent debulking surgery and adjuvant chemotherapy followed by local radiotherapy in an attempt to achieve complete response. Despite being a rare entity, EMP of the NLD should be considered in the differential diagnosis of epiphora and dacryocystitis. To our knowledge, this is the first case of a plasmacytoma of the NLD presenting as isolated extramedullary relapse of MM. The follow-up in EMPs should include appropriate imaging studies, a systemic workup to rule out MM

Does sustainability pay? Evidence from the food sector

This research investigates sustainability concepts, linking them with social, environmental, and operational activities in the food supply chain. Building on the literature treating social sustainability as an antecedent of environmental sustainability, we present the effects of environmental sustainability on operational performance using constructs that reflect flexibility, quality, and responsiveness. For this purpose, manufacturing companies in the Turkish food industry are surveyed and 101 responses are collected. A partial least squares structural equation model (PLS-SEM) is constructed to test the reliability and the validity of the measurement model and the structural model. The results show that social sustainability is positively associated with environmental sustainability. Moreover, environmental sustainability has a positive influence on operational performance measures: flexibility, quality, and responsiveness with effect sizes that range from medium to large. Organizations in the food supply chain should consider not only the economic, but also the social and the environmental aspects of sustainability. To do this, governments could inform manufacturers in the food sector about the importance of sustainability and encourage them with different incentives towards more sustainable operational practices. This work establishes that investing in social and environmental sustainability returns increased operational performance. The limitation of the research is the size of the sample. In the future, the questionnaire can be used to compare results from other countries and other sectors

Graphene Oxide Nanosheets Interact and Interfere with SARS‐CoV‐2 Surface Proteins and Cell Receptors to Inhibit Infectivity

From Wiley via Jisc Publications RouterHistory: received 2021-03-13, pub-electronic 2021-05-14Article version: VoRPublication status: PublishedFunder: University of PaduaFunder: UKRI EPSRC; Grant(s): EP/P00119X/1Funder: Turkish Academy of Sciences (TUBA)Funder: Scientific and Technology Council of Turkey; Grant(s): 18AG020Funder: Türkiye Bilimler Akademisi; Id: http://dx.doi.org/10.13039/501100004412; Grant(s): GEBIP 2018Funder: Türkiye Bilimsel ve Teknolojik Araştirma Kurumu; Id: http://dx.doi.org/10.13039/501100004410; Grant(s): 18AG020Funder: Engineering and Physical Sciences Research Council; Id: http://dx.doi.org/10.13039/501100000266; Grant(s): EP/P00119X/1Abstract: Nanotechnology can offer a number of options against coronavirus disease 2019 (COVID‐19) acting both extracellularly and intracellularly to the host cells. Here, the aim is to explore graphene oxide (GO), the most studied 2D nanomaterial in biomedical applications, as a nanoscale platform for interaction with SARS‐CoV‐2. Molecular docking analyses of GO sheets on interaction with three different structures: SARS‐CoV‐2 viral spike (open state – 6VYB or closed state – 6VXX), ACE2 (1R42), and the ACE2‐bound spike complex (6M0J) are performed. GO shows high affinity for the surface of all three structures (6M0J, 6VYB and 6VXX). When binding affinities and involved bonding types are compared, GO interacts more strongly with the spike or ACE2, compared to 6M0J. Infection experiments using infectious viral particles from four different clades as classified by Global Initiative on Sharing all Influenza Data (GISAID), are performed for validation purposes. Thin, biological‐grade GO nanoscale (few hundred nanometers in lateral dimension) sheets are able to significantly reduce copies for three different viral clades. This data has demonstrated that GO sheets have the capacity to interact with SARS‐CoV‐2 surface components and disrupt infectivity even in the presence of any mutations on the viral spike. GO nanosheets are proposed to be further explored as a nanoscale platform for development of antiviral strategies against COVID‐19

On the Determinants of Green Technology Diffusion: An Empirical Analysis of Economic, Social, Political, and Environmental Factors

The purpose of this study is to investigate the importance of economic, social, political, and environmental factors in determining green technology diffusion. We use a unique annual panel dataset covering 58 nations from 1990 to 2019. Based on dynamic panel data models estimated using system generalized method of moments (GMM), we test whether the technological achievement of nations, general technology diffusion trends, environmental performance, democratic accountability, income distribution, foreign direct investment, income level, and socioeconomic conditions are significant determinants. Our findings indicate that green technology diffusion has a significant relationship with all of these factors. We obtain new evidence that general or brown technological innovation, diffusion, and achievement trends in a country are significant drivers of environmental technology diffusion. The findings of our paper have significant implications for sustainable development, given the importance of green products and technologies. The results of the study suggest that policies aimed at promoting the diffusion of green technologies may not be successful in the presence of unfavorable economic, social, political, or environmental conditions

Analysis of Content Profiles, Antioxidant and Anticancer Properties in Endemic <i>Hypericum salsolifolium</i>

This study investigated the antioxidant and anticancer properties, phenolic compounds, and content profile of Hypericum salsolifolium plant extracts prepared with different solvents. The total phenolic content, total flavonoid content, and antioxidant potential [(2,2-diphenyl-1-picrylhydrazyl, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), ferric reducing antioxidant power, and cupric reducing antioxidant capacity assays] of Hypericum salsolifolium extracts obtained using solvents of different polarities (hexane, dichloromethane, methanol, and water) were measured using spectrophotometric methods. The contents of the extracts were analyzed using liquid chromatography–mass spectrometry and inductively coupled plasma—mass spectrometry methods. Anticancer detection was performed in human lung carcinoma cells using the 3-4,5-dimethylthiazol-2,5-diphenyltetrazolium bromide, annexin-V, and cell cycle assays, as well as fluorescence detection of acridine orange/ethidium bromide staining. The methanolic extract was determined to have higher activation values of total phenolics, total flavonoids, ferric reducing antioxidant power, and in the 2,2-diphenyl-1-picrylhydrazyl assay than the other extracts, and the aqueous extract had higher values in the 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) and cupric reducing antioxidant capacity assays. The methanolic extract showed a cytotoxic effect against human lung carcinoma cells (IC50: 141.96 µg/mL). It was found that Hypericum salsolifolium extract showed antioxidant and anticancer activities. It was concluded that this plant can be used as a nutritional supplement due to its glucose, phenolic compound, amino acid, and vitamin content

Primary Burkitt’s Lymphoma Presenting as a Rapidly Growing Thyroid Mass

A 31-year-old male patient presented with a rapidly growing neck mass with normal thyroid function tests. Ultrasonography showed thyroidal expansion, a hypoechoic nodule that completely filled the right lobe, and 2 hypoechoic lymphadenopathies in the right jugulodigastric chain. The patient underwent right total and left subtotal thyroidectomy, following the diagnosis of nodular goiter; however, postoperative histopathological evaluation demonstrated primary Burkitt’s lymphoma of the thyroid gland. The tumor was staged as stage 1, and R-hyper-CVAD protocol (rituximab, hyperfractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone) was administered. The protocol was changed to R-CHOP after 4 cycles due to recurrent grade III/IV cytopenias and febrile neutropenia. The PET-CT scans performed after chemotherapy and at the 6-month follow-up were normal. In summary, we reported a case with a diagnosis of Burkitt’s lymphoma, which is a rare type of primary thyroid lymphoma

A CASE OF COEXISTENT ADENOCARCINOMA OF THE STOMACH AND T-CELL LYMPHOMA OF THE STOMACH AND JEJUNUM

Acase with a rare coexistence of adenocarcinoma of the stomach and T-cell lymphoma of the stomach and jejunum, diagnosed postoperatively, was reported. The patient underwent surgical intervention for passage problems and a distal subtotal gastrectomy and Roux-En-Y gastrojejunostomy were performed and the approach for the intestinal lymphoma was discussed