A Hierarchical Taxonomy of Psychopathology Can Transform Mental Health Research

For more than a century, research on psychopathology has focused on categorical diagnoses. Although this work has produced major discoveries, growing evidence points to the superiority of a dimensional approach to the science of mental illness. Here we outline one such dimensional system—the Hierarchical Taxonomy of Psychopathology (HiTOP)—that is based on empirical patterns of co-occurrence among psychological symptoms. We highlight key ways in which this framework can advance mental-health research, and we provide some heuristics for using HiTOP to test theories of psychopathology. We then review emerging evidence that supports the value of a hierarchical, dimensional model of mental illness across diverse research areas in psychological science. These new data suggest that the HiTOP system has the potential to accelerate and improve research on mental-health problems as well as efforts to more effectively assess, prevent, and treat mental illness.FSW – Publicaties zonder aanstelling Universiteit Leide

A molecular and parasitological survey on cutaneous leishmaniasis patients from historical city of Kashan in Isfahan province, center of Iran

Objective: To study cutaneous leishmaniasis (CL) for identifying the dominant Leishmania species on CL patients referred to medical health centers of historical Kashan city and suburbs located in Isfahan province in central part of Iran during 2010 to 2011. Methods: From 137 CL cases, were microscopically positive, the skin lesion serosity materials of 103 cases were cultured in monophasic culture media (RPMI 1 640). We used the PCR-RFLP method for characterization the Leishmania isolates, by using specific internal transcribed spacer (ITS1) primers and HAEShcyrillic as the restriction fast enzyme. DNA was extracted from 63 samples. Results: L. tropica is main species in 58 (92.1) cases and L. major is identified in 5 (7.9) cases. Indeed randomly two isolates were the species characterized as L. major produced ulcer at the base tail of BALB/c mice after 3 weeks but from three L. tropica isolates none of them produced any lesion during 6 months post inoculation. Conclusions: The parasitological, epidemiological aspect and molecular methods of this study showed that, Kashan and suburb are anthroponetic CL area despite this city located in Isfahan province as an ancient focus of zoonotic CL in Iran. © 2012 Asian Pacific Tropical Medicine Press

Execution and reliability of slip resistant connections for steel structures using CS and SS (SIROCO)

SIROCO investigated the slip-resistant behaviour of carbon and stainless steel preloaded connections as well as the preloading behaviour of stainless steel bolting assemblies in principle. The slip factor test procedure according to Annex G of EN 1090-2 was investigated regarding the influence of the test speed, preload level, tightening method, criteria for the slip load and load level for extended creep tests, different bolting assemblies and surface conditions (grit blasted, hot-dip galvanized, alkali/ethyl zinc silicate coating, thermally sprayed with aluminium/zinc and combinations). Improvements regarding the slip factor test procedure have been formulated which have already partly been implemented in the revision of EN 1090-2. Enhanced slip factors allow more economic slip-resistant connections. The use of stainless steel bolting assemblies in preloaded bolted slip-resistant connections joining stainless steel plates was studied through investigations into the creep/relaxation behaviour with regard to potential preload losses, the tightening and slip resistance behaviour for austenitic, duplex, lean duplex and super duplex stainless steels. Preload losses due to the viscoplastic deformation behaviour in preloaded stainless steel bolting assemblies lie in the same range as those for carbon steel. Stainless steel bolting assemblies are in principle preloadable and galling can be avoided using suitable lubricants and tightening methods. Slip factors for stainless steel slip-resistant connections show high values for grit blasted surfaces whereas even 1D and shot blasted surfaces demonstrated slip factors for practical use. Recommendations for design and execution of slip-resistant connections and amendments to EN 1993 1-4, EN 1993-1-8 and EN 1090-2 are formulated.Steel & Composite Structure

How do substance use disorders compare to other psychiatric conditions on structural brain abnormalities? A cross-disorder meta-analytic comparison using the ENIGMA consortium findings

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Validation française du Caregiving Strain Questionnaire sur une population de parents d’enfants avec troubles du spectre de l’autisme

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