بازاندیشی در مفهوم حق بر آموزش در پرتو شهروندی دموکراتیک

Background and Aim: Education is not only one of the important examples of human rights but also an important tool for the realization of other examples of human rights. The guarantee and enforcement of this right is a prelude to the guarantee and enforcement of other instances of human rights. The right to education was initially recognized as a general and flexible principle that had no clear and binding legal obligations under the Universal Declaration of Human Rights. Due to the fundamental differences that existed in the legal-political systems of governments, the development and strengthening of this right was entrusted to regional and domestic legal systems. Materials and Methods: In this study with analytical-descriptive method, first the concept of citizenship and the importance of education will be discussed. After determining the status of this variable, the objectives of the educational process and the concept of "right to education" will be considered to explain more precisely the general framework of the main issue of the present study. In the third step, the teaching of democracy, tolerance and tolerance as the main criteria for promoting democratic citizenship will be discussed. Ethical Considerations: In order to organize this research, while observing the authenticity of the texts, honesty and fidelity have been observed. Findings: Within the framework of the right to empowerment, education is a mechanism by which individuals can acquire the tools necessary for full participation in society. Education plays a very important role in empowering the vulnerable, promoting human rights and democracy, providing the necessary conditions for sustainable development, and so on. As a result, education is considered as one of the best materials and spiritual investments that a government can make for the development, progress and welfare of its citizens. Conclusion: Developments in the right to education and implementation and its guarantee within the framework of the doctrine of democratic citizenship and, consequently, its relationship with the development and strengthening of the concept of rule of law and its constituent elements can in the process of educating citizens committed to democracy and creating a legal-political system. The main and most effective guarantee of its implementation will be the real pressure of public opinion and public demand, to play a key role.   Please cite this article as: Rostami S, Soleymanzadeh T. A Rethinking of the Concept of Right to Education in the Light of Democratic Citizenship. Bioethics Journal, Special Issue on Bioethics and Citizenship Rights 2020; 173-186.زمینه و هدف: آموزش علاوه بر این‌که یکی از مصادیق مهم حقوق بشر است، ابزاری مهم برای تحقق سایر مصادیق حقوق بشر نیز به شمار می‌رود. تضمین و اجرای حق آموزش مقدمه تضمین و اجرای سایر مصادیق حقوق بشر می‌باشد. حق بر آموزش ابتدعاً در قامت یک اصل کلی و منعطف که فاقد تعهدات حقوقی مشخص و الزام‌آور بود، در قالب اعلامیه جهانی حقوق بشر پذیرفته شد. به علت تفاوت‌های بنیادینی که در نظام‌های حقوقی ـ سیاسی دولت‌ها وجود داشت، توسعه و تقویت حق مزبور به نظام‌های حقوقی منطقه‌ای و داخلی سپرده شد. مواد و روش‌ها: در این مطالعه با روش تحلیلی ـ توصیفی، ابتدا مفهوم شهروندی و اهمیت آموزش بحث و بررسی خواهد شد. پس از مشخص‌شدن وضعیت متغیر مزبور، اهداف فرآیند آموزشی و مفهوم «حق بر آموزش» برای تبیین دقیق‌تر چارچوب کلی مسأله اصلی پژوهش حاضر و سپس آموزش دموکراسی، تسامح و تساهل به عنوان معیار اصلی برای ترویج شهروندی دموکراتیک مورد بحث و بررسی قرار خواهد گرفت. ملاحظات اخلاقی: در تمام مراحل نگارش پژوهش حاضر، ضمن رعایت اصالت متون، صداقت و امانتداری رعایت شده است. یافته‌ها: در چارچوب حق بر توانمندسازی، آموزش سازکاری است که با استفاده از آن، افراد می‌توانند ابزارهای لازم را برای مشارکت کامل در جوامع به دست آورند. آموزش نقش بسیار مهمی را در توانمندسازی اقشار آسیب‌پذیر، ترویج حقوق بشر و دموکراسی، فراهم کردن زمینه‌های لازم برای توسعه پایدار و... ایفا می‌کند، در نتیجه آموزش به عنوان یکی از بهترین سرمایه‌گذاری‌های مادی و معنوی محسوب می‌شود که یک دولت می‌تواند در راستای توسعه، پیشرفت و رفاه شهروندان خود، انجام دهد. نتیجه‌گیری: تحولات حق بر آموزش و اجرا و تضمین آن در چارچوب دکترین شهروندی دموکراتیک و در نتیجه، ارتباط آن با توسعه و تقویت مفهوم حکومت قانون و عناصر تشکیل‌دهنده آن، در فرآیند تربیت شهروندان پایبند به دموکراسی و ایجاد یک نظام حقوقی ـ سیاسی که اصلی‌ترین و کارآمدترین ضمانت اجرای آن فشار واقعی افکار عمومی و مطالبه‌گری عموم مردم خواهد بود، نقش اساسی ایفا کند

The relationship of spiritual intelligence factors and tendency to addiction and Its comparison between girls and boys students

For downloading the full-text of this article please click here.Background and Objectives: Addiction is a chronic disease characterized by individual, physiological and social dysfunction.  Spiritual Intelligence is the ability to experience Situations that allow individuals to achieve greater knowledge and understanding and providing Grounds in life the to achieve perfection and progress.Spiritual intelligence effects tendency to high-risk behaviors as addiction. Present study aimed to determine the relationship of spiritual intelligence factors and tendency to addiction on girls and boys students. Materials and Methods: in this study, 100 students were selected among students of Kashan university using multiple cluster sampling. Methodology was correlation. Data were collected by questionnaires of spiritual intelligence and tendency to addiction and were analyzed using Pearson’s correlation coefficient and multi variable regression. Results: results indicated that there was significant relationship between the factors of understanding and communication with source and spiritual life with tendency to addiction (P<0/01). This relationship wasn’t different between girls and boys students. In addition, results showed that understanding and communication with source and spiritual life can predict tendency to addiction) P<0/01( Conclusion: The results provide some evidence that the factors of spiritual intelligence can predict part of changes of tendency to addiction. Therefore, in order to decrease the tendency of individuals to addiction suggested that their spiritual ability have been enhanced by doing cultural- educational packages. Keywords: spiritual intelligence, communication with source, spiritual life, tendency to addictionFor downloading the full-text of this article please click here

Effect of Occupational Therapy Clinical Training on Self-Efficacy and Clinical Reasoning of Students

Background & Objective: The ultimate goal of medical universities is clinical efficacy in their students. Students’ evaluation of self-efficacy can be a good guide to predicting their clinical skills. Therefore, this research was designed to evaluate the effect of occupational therapy clinical training during one semester on self-efficacy and clinical reasoning in students and the relationship between these two factors. Methods: This descriptive-analytical and cross-sectional study was conducted on 42 third and fourth year undergraduate students of occupational therapy who were passing the clinical education course. The study was conducted in all occupational therapy clinical centers of Jundishapur University of Medical Sciences, Ahvaz, Iran, through census sampling in 2014. The General Self-Efficacy Scale (10 questions) and Self-Assessment of Clinical Reflection and Reasoning (26 questions) were used in this study. Data were analyzed using descriptive statistics and parametric tests such as paired t-test, independent t-test, and the Pearson correlation coefficient in SPSS software. Results: Results indicated a significant change (from 29.97 ± 3.87 in pre-test to 31.80 ± 4.04 in post-test) in students' self-efficacy during one semester (P = 0.009). However, the increase in mean scores of clinical reasoning and self-reflection at the end of the semester was not significant (P = 0.460). There was a weak correlation between the self-efficacy variable and clinical reasoning and self-reflection (P = 0.010, r = 0.39). Scores did not show statistically significant differences in either cases and between the two sexes Conclusion: According to the results of this study, clinical training program in the field of occupational therapy led to the creation and promotion of self-efficacy in students, but does not increase clinical reasoning among them. Therefore, revision of clinical training of students and improvement of their clinical courses’ plans seems necessary. Key Words: Clinical education, Self-efficacy, Clinical reasoning, Students, Occupational therap

Educational Quality and Facilities Assessment in the Department of Restorative Dentistry from the Viewpoint of Dentistry Students of Kerman University of Medical Sciences, Iran, in 2014

Background & Objective: Restorative dentistry is a fundamental field in dentistry and students’ opinions about its education can be helpful in finding its deficiencies and solving them. The aim of this study was to evaluate dentistry students’ attitudes toward restorative dentistry education, and its facilities and physical environment. Methods: This descriptive, cross-sectional study was performed on fourth, fifth, and sixth year students of the School of Dentistry of Kerman University of Medical Sciences, Iran. The data collection tool was a two-part questionnaire consisting of demographic characteristics form and 38 questions about environment, facilities, and educational and exam methods, and 1 open question scored based on a Likert scale (very appropriate to inappropriate). Data were analyzes using t-test, ANOVA, and linear regression in SPSS software. The significant level was considered as 0.05 in all tests. Results: Among the 110 participates, 61.8% were women and 38.2% were men. The average attitude score (from 26 to 130) was 84.86 ± 11.30. Overall attitude score was not significantly different between genders, academic years, and different restorative scores. However, in the education field, the fifth and sixth year students had significantly higher attitude scores than the fourth year students. Conclusion: Satisfaction with the clinical and theoretical education of restorative dentistry in the School of Dentistry of Kerman University of Medical Sciences is acceptable, but its physical environment and facilities must be improved. Key Words: Restorative dentistry, Education, Students, Attitude, Kerman (Iran

The evolution of seafloor spreading behind the tip of the westward propagating Cocos-Nazca spreading center

Author Posting. © American Geophysical Union, 2020. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geochemistry, Geophysics, Geosystems 21(6), (2020): e2020GC008957, doi:10.1029/2020GC008957.At the Galapagos triple junction in the equatorial Pacific Ocean, the Cocos‐Nazca spreading center does not meet the East Pacific Rise (EPR) but, instead, rifts into 0.4 Myr‐old lithosphere on the EPR flank. Westward propagation of Cocos‐Nazca spreading forms the V‐shaped Galapagos gore. Since ~1.4 Ma, opening at the active gore tip has been within the Cocos‐Galapagos microplate spreading regime. In this paper, bathymetry, magnetic, and gravity data collected over the first 400 km east of the gore tip are used to examine rifting of young lithosphere and transition to magmatic spreading segments. From inception, the axis shows structural segmentation consisting of rifted basins whose bounding faults eventually mark the gore edges. Rifting progresses to magmatic spreading over the first three segments (s1–s3), which open between Cocos‐Galapagos microplate at the presently slow rates of ~19–29 mm/year. Segments s4–s9 originated in the faster‐spreading (~48 mm/year) Cocos‐Nazca regime, and well‐defined magnetic anomalies and abyssal hill fabric close to the gore edges show the transition to full magmatic spreading was more rapid than at present time. Magnetic lineations show a 20% increase in the Cocos‐Nazca spreading rate after 1.1 Ma. The near‐axis Mantle Bouguer gravity anomaly decreases eastward and becomes more circular, suggesting mantle upwelling, increasing temperatures, and perhaps progression to a developed melt supply beneath segments. Westward propagation of individual Cocos‐Nazca segments is common with rates ranging between 12 and 54 mm/year. Segment lengths and lateral offsets between segments increase, in general, with distance from the tip of the gore.E. M. and H. S. are grateful to the National Science Foundation for funding this work and to InterRidge and the University of Leeds for providing support for a number of the international students and scholars who were able to participate on the cruise. We are also grateful for the extraordinary work of the Captain and crew of R/V Sally Ride , whose efficiency and good cheer made the cruise such a success. We thank M. Ligi and two anonymous reviewers for their comments which greatly improved the manuscript. Any opinion, findings, and conclusions or recommendations expressed in this material are those of the authors and do not necessarily reflect the views of the National Science Foundation.2020-11-1

Study of type and frequency of Alfa-thalassemia mutations in a cohort of 3,823 patients from Isfahan Province, Iran

Introduction: Alpha-thalassemia (α-thalassemia) is caused by a range of mutations in the α-globin gene resulting in the complete reduction or absence of α-globin chain production. Material and methods: This study assessed the presence of α-thalassemia in 3,823 patients referred to Al-Zahra Hospital, Isfahan, Iran during a 10-year period (from 2012 to 2022). These patients experienced anaemia for more than ten years but had not the full indication for β-thalassemia or iron deficiency. Results: Based on the present assessment, 3,483 cases out of 3,823 suspicious cases had an α-Thalassemia-involved mutation (91.1%). According to the results, the most common detected mutation in the α-thalassemia carriers of Isfahan province was –α3.7 with a frequency of 81.58% (3,119 individuals), followed by α5nt (–TGAGG) (3.71% in total or 39.01% between 364 patients), polyadenylation signal mutations (polyA2) (14.28% between 364 patients), αcodon 19 (GCG4GC–, a2) (11.53%), –α3.7/–α3.7 (11.53%), –α20.5 (7.69%), Hb Constant Spring [Hb CS, a142, Stop →Gln; HBA2: c.427T4C] (5.7%), α4.2 (5.49) and – –MED (4.67%). Conclusion: The results of this investigation may be valuable for designing a program for carrier screening, premarital genetic counselling, and prenatal diagnosis in the Isfahan province

Sensing of Alzheimer’s Disease and Multiple Sclerosis Using Nano-Bio Interfaces

It is well understood that patients with different diseases may have a variety of specific proteins (e.g., type, amount, and configuration) in their plasmas. When nanoparticles (NPs) are exposed to these plasmas, the resulting coronas may incorporate some of the disease-specific proteins. Using gold (Au) NPs with different surface properties and corona composition, we have developed a technology for the discrimination and detection of two neurodegenerative diseases, Alzheimer's disease (AD) and multiple sclerosis (MS). Applying a variety of techniques, including UV-visible spectra, colorimetric response analyses and liquid chromatography-tandem mass spectrometry, we found the corona-NP complexes, obtained from different human serums, had distinct protein composition, including some specific proteins that are known as AD and MS biomarkers. The colorimetric responses, analyzed by chemometrics and statistical methods, demonstrate promising capabilities of the technology to unambiguously identify and discriminate AD and MS. The developed colorimetric technology might enable a simple, inexpensive and rapid detection/discrimination of neurodegenerative diseases. KEYWORDS: Alzheimer’s disease; colorimetric technology; disease-specific protein corona; gold nanoparticles; multiple sclerosi

BRF1 accelerates prostate tumourigenesis and perturbs immune infiltration

BRF1 is a rate-limiting factor for RNA Polymerase III-mediated transcription and is elevated in numerous cancers. Here, we report that elevated levels of BRF1 associate with poor prognosis in human prostate cancer. In vitro studies in human prostate cancer cell lines demonstrated that transient overexpression of BRF1 increased cell proliferation whereas the transient downregulation of BRF1 reduced proliferation and mediated cell cycle arrest. Consistent with our clinical observations, BRF1 overexpression in a Pten-deficient mouse (Pten BRF1 ) prostate cancer model accelerated prostate carcinogenesis and shortened survival. In Pten BRF1 tumours, immune and inflammatory processes were altered, with reduced tumoral infiltration of neutrophils and CD4 positive T cells, which can be explained by decreased levels of complement factor D (CFD) and C7 components of the complement cascade, an innate immune pathway that influences the adaptive immune response. We tested if the secretome was involved in BRF1-driven tumorigenesis. Unbiased proteomic analysis on BRF1-overexpresing PC3 cells confirmed reduced levels of CFD in the secretome, implicating the complement system in prostate carcinogenesis. We further identify that expression of C7 significantly correlates with expression of CD4 and has the potential to alter clinical outcome in human prostate cancer, where low levels of C7 associate with poorer prognosis