Impedance control network resonant dc-dc converter for wide-range high-efficiency operation

This paper introduces a new resonant converter architecture that utilizes multiple inverters and a lossless impedance control network (ICN) to maintain zero voltage switching (ZVS) and near zero current switching (ZCS) across wide operating ranges. Hence, the ICN converter is able to operate at fixed frequency and maintain high efficiency across wide ranges in input and output voltages and output power. The ICN converter architecture enables increase in switching frequency (hence reducing size and mass) while achieving very high efficiency. A prototype 200 W, 500 kHz ICN resonant converter designed to operate over an input voltage range of 25 V to 40 V and output voltage range of 250 V to 400 V is built and tested. The prototype ICN converter achieves a peak efficiency of 97.2%, maintains greater than 96.2% full power efficiency at 250 V output voltage across the nearly 2:1 input voltage range, and maintains full power efficiency above 94.6% across its full input and output voltage range. It also maintains efficiency above 93.4% over a 10:1 output power range across its full input and output voltage range owing to the use of burst-mode control.National Science Foundation (U.S.) (Award 1307699

Prevalence of hepatitis B and C viral infections in Pakistan: Findings of a national survey appealing for effective prevention and control measures

A prevalence survey on hepatitis B and C infections was carried out to obtain national estimates and assess epidemiological dynamics and underlying risk factors. Overall prevalence of hepatitis B surface antigen (HBsAg) and anti-hepatitis C virus (HCV) of 2.5% and 4.8%, respectively, reflected a combined infection rate of 7.6% in the general population, consistent with an ongoing high burden of chronic liver disease (CLD). There was significant association of these viral infections with a range of risk factors led by reuse of syringes. These findings validate currently implemented strategies by the national programme for the control of hepatitis viral infections, including universal vaccination of newborns and high-risk groups, support of auto-disable syringes, promotion of infection control and patient safety, public health education, and management of needy CLD patients as a poverty-reduction health intervention

Design and evaluation of a reconfigurable stacked active bridge dc/dc converter for efficient wide load-range operation

This paper presents the design and implementation of a large-step-down soft-switched dc-dc converter based on the active bridge technique which overcomes some of the limitations of the conventional Dual Active Bridge (DAB) converter. The topology comprises a double stacked-bridge inverter coupled to a reconfigurable rectifier through a special three-winding leakage transformer. This particular combination of stages enable the converter to run in an additional low-power mode that greatly increases light-load efficiency by reducing core loss and extending the zero-voltage switching (ZVS) range. The converter is implemented with a single compact magnetic component, providing power combining, voltage transformation, isolation, and energy transfer inductance. A 175 kHz, 300 W, 380 V to 12 V GaN-based prototype converter achieves 95.9% efficiency at full load, a peak efficiency of 97.0%, an efficiency above 92.7% down to 10% load and an efficiency above 79.8% down to 3.3% load.National Science Foundation (U.S.) (Award Number 1307699)MIT Skoltech Initiativ

Impedance Control Network Resonant Step-Down DC-DC Converter Architecture

In this paper, we introduce a step-down resonant dc-dc converter architecture based on the newly-proposed concept of an Impedance Control Network (ICN). The ICN architecture is designed to provide zero-voltage and near-zero-current switching of the power devices, and the proposed approach further uses inverter stacking techniques to reduce the voltages of individual devices. The proposed architecture is suitable for large-step-down, wide-input-range applications such as dc-dc converters for dc distribution in data centers. We demonstrate a first-generation prototype ICN resonant dc-dc converter that can deliver 330 W from a wide input voltage range of 260 V – 410 V to an output voltage of 12 V.MIT Skoltech InitiativeMIT Energy InitiativeNational Science Foundation (U.S.) (Award 1307699)Texas Instruments Incorporated (Graduate Women's Fellowship for Leadership in Microelectronics

Beam power scale-up in MEMS based multi-beam ion accelerators

We report on the development of multi-beam RF linear ion accelerators that are formed from stacks of low cost wafers and describe the status of beam power scale-up using an array of 120 beams. The total argon ion current extracted from the 120-beamlet extraction column was 0.5 mA. The measured energy gain in each RF gap reached as high as 7.25 keV. We present a path of using this technology to achieve ion currents >1 mA and ion energies >100 keV for applications in materials processing

E-Mobility -- Advancements and Challenges

Mobile platforms cover a broad range of applications from small portable electric devices, drones, and robots to electric transportation, which influence the quality of modern life. The end-to-end energy systems of these platforms are moving toward more electrification. Despite their wide range of power ratings and diverse applications, the electrification of these systems shares several technical requirements. Electrified mobile energy systems have minimal or no access to the power grid, and thus, to achieve long operating time, ultrafast charging or charging during motion as well as advanced battery technologies are needed. Mobile platforms are space-, shape-, and weight-constrained, and therefore, their onboard energy technologies such as the power electronic converters and magnetic components must be compact and lightweight. These systems should also demonstrate improved efficiency and cost-effectiveness compared to traditional designs. This paper discusses some technical challenges that the industry currently faces moving toward more electrification of energy conversion systems in mobile platforms, herein referred to as E-Mobility, and reviews the recent advancements reported in literature

Evaluation of quality of life in adults with neurofibromatosis 1 (NF1) using the Impact of NF1 on Quality Of Life (INF1-QOL) questionnaire

Background Neurofibromatosis 1 (NF1) is an inherited, multi-system, tumour suppressor disorder with variable complications that cause psychological distress and social isolation. The study aim was to develop and validate a disease-specific questionnaire to measure quality of life (QOL) in NF1 that is suitable both as an assessment tool in clinical practice and in clinical trials of novel therapy. Methods The Impact of NF1 on Quality of Life (INF1-QOL) questionnaire was developed by a literature search for common terms, focus group (n=6), semi-structured interviews (n=21), initial drafts (n =50) and final 14 item questionnaire (n=50). Bivariate correlations between items, exploratory factor analysis, correlations with severity and EuroQol were employed. Results INF1-QOL showed good internal reliability (Cronbach’s alpha 0.87), mean total INF1-QOL score was 8.64 (SD 6.3), median 7.00, range 0-30 (possible range 0-42); no significant correlations with age or gender. The mean total EuroQol score was 7.38 (SD 2.87), median 6.5, mean global EuroQol score was 76.34 (SD 16.56), median 80. Total INF1-QOL score correlated with total EuroQol r=0.82, p<0.0001. The highest impact on QOL was moderate or severe problems with anxiety and depression (32%) and negative effects of NF1 on role and outlook on life (42%). The mean inter-relater reliability for grading of clinical severity scores was 0.71 (range 0.65-0.79), and intra-class correlation was 0.92. The mean clinical severity score was 1.95 (SD 0.65) correlating r=0.34 with total INF1-QOL score p<0.05 and correlated 0.37 with total EuroQol score p<0.01. The clinical severity score was mild in 17 (34%), moderate in 16 (32%) and 17 (34%) individuals had severe disease. Conclusions INF1-QOL is a validated, reliable disease specific questionnaire that is easy and quick to complete. Role and outlook on life and anxiety and depression have the highest impact on QOL indicating the variability, severity and unpredictability of NF1. INFI-QOL correlates moderately with clinical severity. The moderate relationship between INF1-QOL and physician rated severity emphasizes the difference between clinical and patient perception. INFI-QOL will be useful in individual patient assessment and as an outcome measure for clinical trials

Factors influencing uptake of voluntary counselling and testing services for HIV/AIDS in the Lower Manya Krobo Municipality (LMKM) in the Eastern Region of Ghana: a cross-sectional household survey

Background Voluntary counselling and testing (VCT) is one of the nine strategies recommended for prevention and control of HIV globally. In this study, we assessed the awareness and utilisation of VCT services among residents of the Lower Manya Krobo Municipality (LMKM) in the Eastern Region of Ghana. Methods A population-based descriptive cross-sectional survey was conducted with 200 participants, aged between 18 and 55 years. Participants were recruited using cluster and simple random techniques to take part in the survey. Data was analysed descriptively, as well as using regression analysis approach. Results Ninety-one percent of the respondents surveyed were aware of VCT services for HIV/AIDS. Seventy percent (70 %) have used VCT service in the last 12 months prior to the survey. Of this proportion, 97 % were satisfied with the quality of VCT services offered and indicated their willingness to recommend the service to others. Participants desire to know their HIV status (40 %), referral by health workers (25 %), and participants who wanted to get married (11 %) were the main reasons for increased uptake. Participants who had formal education, primary (OR = 1.8 (95 % CI 1.25–2.84)), junior high school (OR = 2.3 (95 % CI 1.54–3.37)), senior high school (OR = 2.8 (95 % CI 1.73–4.78)), and tertiary (OR = 3.4 (95 % CI 1.98–8.42)), had increased chance of using VCT service compared with participants who had no education (p < 0.001). Reasons for non-utilisation of VCT service were lack of awareness of the VCT service in the area (32 %), fear of being stigmatised (53 %), and the belief that HIV/AIDS cannot be cured and therefore the lack of need (5 %). Conclusions Although awareness and utilisation of VCT service rates were reportedly high, more efforts need to be done in order to increase awareness and promote utilisation. HIV/AIDS educational campaign programmes need to be strongly pursued, with emphasis on the benefits of VCT services. This has the potential of reducing stigma and increase utilisation