Shuttle/spacelab MMAP/electromagnetic environment experiment phase B definition study

Progress made during the first five months of the Phase B definition study for the MMAP/Electromagnetic Environment Experiment (EEE) was described. An antenna/receiver assembly has been defined and sized for stowing in a three pallet bay area in the shuttle. Six scanning modes for the assembly are analyzed and footprints for various antenna sizes are plotted. Mission profiles have been outlined for a 400 km height, 57 deg inclination angle, circular orbit. Viewing time over 7 geographical areas are listed. Shuttle interfaces have been studied to determine what configuration the antenna assembly must have to be shared with other experiments of the Microwave Multi-Applications Payload (MMAP) and to be stowed in the shuttle bay. Other results reported include a frequency plan, a proposed antenna subsystem design, a proposed receiver design, preliminary outlines of the experiment controls and an analysis of on-board and ground data processing schemes

MicroRNA-377 expression level as a marker of nephropathy in Type 2 diabetes mellitus

Background: Diabetic nephropathy is one of the most dangerous complications of diabetes mellitus. To prevent these complications in diabetic patients monitoring of patients is a must. In last decades many authors were trying to investigate molecular biomarker to detect patients who are at risk. MicroRNA-377 is one of the promising biomarkers for prediction of diabetic nephropathy. Objective: This study aimed to investigate the role of miRNA-377 as early predictor of diabetic nephropathy in patients with type 2 diabetes mellitus.Patients and methods: Seventy five patients with type 2 diabetes and 25 healthy control participants are enrolled in a case-control study. Clinical evaluation, and laboratory investigations including fasting plasma glucose, serum creatinine, fasting lipid profile, glycosylated hemoglobin, estimated glomerular filtration rate (eGFR) and albumin creatinine ratio, The expression of serum miRNA-377 was measured via quantitative real-time-polymerase chain reaction (qRT-PCR). Results: Expression of miR-377 could differentiate diabetic patients from healthy control as the expression of miR-377 was significantly higher in overall T2DM patients than in the healthy control (2.5 fold change, P<0.001), and was progressively increased in the normoalbuminuric group and further increased in the microalbuminuric and macroalbuminuric groups (1.92, 2.76, 3.38 fold change respectively, P<0.001). MiR-377 expression levels were positively correlated with diabetes duration, fasting plasma glucose, HbA1C, total cholesterol, LDL-C, triglycerides, creatinine and ACR, while miR-377 expression levels were significantly negatively correlated with HDL-C and eGFR.Conclusions: MiR-377 might act as a promising biomarker for prediction of development of diabetic nephropathy in type 2 diabetes patients

Le tératome cervical: A propos de 2 cas

Le tératome est une tumeur embryonnaire généralement localisé au niveau sacro-coccygien. La localisation cervicale est rare, et ne représente que3%, elle est associée à un fort taux de mortalité arrivant jusqu’à 80 % à la période néonatale du fait de l’obstruction des voies aériennes.L’immaturité n’est pas un signe de malignité quand la tumeur est prise en charge à la période néonatale. Nous rapportons 2 cas colligés au servicede chirurgie pédiatrique du CHU HASSAN II de Fès, en mettant en relief qu’il existe encore un manque de diagnostic anténatal, malgrél’amélioration de la prise en charge des nouveaux nés.Key words: Tératome cervical géant, nouveau né, chirurgi

Pengaruh Kemampuan Kerja Dan Motivasi Kerja Terhadap Prestasi Kerja (Studi Pada Karyawan Pr. Sejahtera Abadi Malang)

The research entitled "The Influence of Working Ability and Motivation to Job Performance" conducted on employess in PR.Sejahtera Abadi Malang aims to explain at influence of variables Working Ability Employees and Motivation Employees simultaneously and partially to Job Performance Employees. The research method used is explanatory research, by using questionnaire as to collect data from 71 employees in PR.Sejahtera Abadi Malang. Data analysis used in this research is descriptive analysis and multiple regression using SPSS for windows. The multiple linear regression analysis showed that simultaneously and partially Working Ability Employees and Motivation Employees has a significant influence on Job Performance Employees. This is shown by the results obtained using simultaneous test of significance F value of 0,000 is less than α of 0,05 (0,000 <0,05). This is shown by the results obtained using partially test of significance t value of 0,000 is less than α of 0,05 (0,001 <0,05). Partially results Motivation variables has the highest beta coefficient of 0,481

Wavelet phase evaluation extended to digital speckle patterninterferometry

A wavelet algorithm developed to improve metrology based on electronic speckle pattern intérferometry (ESPI) is presented. The wavelet algorithm is based on the calculation of the continuous wavelet transform of a modulated speckle correlation fringes .The Paul wavelet is used , the extraction of the maximum scales of the modulus of the wavelet transform leads simply to the phase gradient distribution. The advantage of the method is to provide phase distribution, with a high accuracy, from a single interferogram without unwrapping step.A wavelet algorithm developed to improve metrology based on electronic speckle pattern intérferometry (ESPI) is presented. The wavelet algorithm is based on the calculation of the continuous wavelet transform of a modulated speckle correlation fringes .The Paul wavelet is used , the extraction of the maximum scales of the modulus of the wavelet transform leads simply to the phase gradient distribution. The advantage of the method is to provide phase distribution, with a high accuracy, from a single interferogram without unwrapping step

Aneurysmal bone cyst primary - about eight pediatric cases: radiological aspects and review of the literature

The aneurysmal bone cyst is a pseudotumoral lesion that can take several aspects. This is a rare lesion representing 1% of bone tumors. It appears usually during the first 30 years of life. The pathogenesis is that of a process of "dysplasia/hyperplasia", favored by a circulatory deficiency and hemorrhage within the lesion and the phenomena of osteoclasis. The objective of this work is to illustrate with analysis, the specific forms and atypical aneurysmal bone cyst which often pose a diagnostic challenge requiring radiological investigation with histological confirmation. We report eight pediatric cases of aneurysmal cysts collected over a period of 3 years, 3 boys and 5 girls. All patients had standard radiographs. MRI was performed in three patients. The diagnosis was confirmed histologically. The atypia has been in the seat: fibula (1 case), metaphyseal (2 cases), diaphyseal (4 cases) and metatarsal (1 case). Aneurysmal bone cyst is a rare benign tumor with predilection to the metaphysis of long bones. Atypical forms even fewer are dominated by the atypical seat.Key words: Bone cyst, aneurysm, osteolytic lesio

β-Sitosterol Glucoside-Loaded Nanosystem Ameliorates Insulin Resistance and Oxidative Stress in Streptozotocin-Induced Diabetic Rats

β-Sitosterol glucoside (SG), isolated from Senecio petasitis (Family Asteraceae), was loaded in self-nanoemulsifying drug delivery systems (SEDDS) in a trial to enhance its solubility and biological effect. Various co-surfactants were tested to prepare a successful SEDDS. The selected SG-loaded SEDDS had a droplet size of 134 ± 15.2 nm with a homogenous distribution (polydispersity index 0.296 ± 0.02). It also demonstrated a significant augmentation of SG in vitro release by 4-fold compared to the free drug suspension. The in vivo insulin sensitivity and antidiabetic effect of the prepared SG-loaded SEDDS were further assessed in streptozotocin-induced hyperglycemic rats. The hypoglycemic effect of SG-loaded nanosystem was evidenced by decreased serum glucose and insulin by 63.22% and 53.11%, respectively. Homeostasis model assessment-insulin resistance (HOMA-IR) index demonstrated a significant reduction by 5.4-fold in the diabetic group treated by SG-loaded nanosystem and exhibited reduced glucagon level by 40.85%. In addition, treatment with SG-loaded nanosystem significantly decreased serum MDA (malondialdehyde) and increased catalase levels by 38.31% and 64.45%, respectively. Histopathological investigations also supported the protective effect of SG-loaded nanosystem on the pancreas. The promising ability of SG-loaded nanosystem to ameliorate insulin resistance, protect against oxidative stress, and restore pancreatic β-cell secretory function warrants its inclusion in further studies during diabetes progression

Circulating dendritic cells in pediatric patients with nephrotic syndrome

Background: Dendritic cells (DCs) represent one of the most extensively studied topics in immunology, because of their central role in the induction and regulation of adaptive immunity, and because of their therapeutic potential for manipulating immune responses. Objectives: To evaluate circulating DC levels in pediatric patients with idiopathic nephrotic syndrome (NS) and its relation to disease activity in these patients. Methods: Fifteen nephrotic patients in relapse (proteinuria>40mg/m2/hour, hypoalbuminemia, and edema) before initiating steroid therapy (Group I), and another15 nephrotic patients in remission after withdrawal of steroid therapy (Group II) were compared to 15 age- and sex- matched healthy children. Besides clinical evaluation and routine laboratory investigations of nephrotic syndrome, circulating DCs were measured by flowcytometry. Results: Circulating DC count was lower in nephrotic patients in both proteinuria and remission groups [(48.89±13.52) and (64.64±7.69) X106/liter respectively] than in the control group (78.54±9.8) X106/liter with highly significant statistical difference (p < 0.001), and lower in proteinuria group than the remission group with highly significant statistical difference (p < 0.001). There was a positive correlation between DC count and serum albumin (moderate association) (p=0.002) and a negative correlation between DC count and urine protein /creatinine ratio (strong association) (p=0.001). Conclusion: Nephrotic syndrome was associated with decreased number of circulating DCs and the decrease was more apparent in patients with active disease. The positive correlation between DC counts and total protein, and serum albumin, and the negative correlation between DC count and urine protein/creatinine ratio point to the link between the decrease in DC count and the severity of the disease process.Keywords: Denderitic cells, nephrotic syndrome, immune deficiencyEgypt J Pediatr Allergy Immunol 2011;9(1):41-4