Studies on Combined Toxicity of Pendimethalin and Cadmium Chloride with Ameliorative Effect of Vitamin E-Selenium and Turmeric in Male Albino Rats

The present investigation was undertaken to study the pathology of pendimethalin and cadmium chloride and to evaluate the different concentration were used as ameliorative agents to reduce theoxidative damage caused by free redicals genreted by toxic pollutants at molecular levels. A total of 5 groups each of 12 rats were formed apart from control group. 2 groups of heavy metal and pesticide and 3 group of ameliorative oxidant in varying concentrations were formed Group T2 was given standard ration along with combination of cadmium chloride at 500 ppm with pendimethalin (38.7%) at 1000 ppm/kg feed, Group T3 was given cadmium chloride at 100ppm/kg feed and P pendimethalin (38.7%) at 1000 ppm/kg feed with standard ration, Group T4 was fed with the combination of cadmium chloride at 50 ppm/kg of feed with pendimethalin at 1000 ppm/kg of feed and alpha tocopherol-selenium at 18 ppm/kg of feed. Lastly group T5 and T6 were given turmeric at 0.5%and 1% concentrations respectively along with the combination of cadmium chloride at 50 ppm with pendimethalin (38.7%) at 1000ppm and alpha tocopherol-selenium at18ppm/kg of feed.  During the toxicity studies observation like effect on CNS, effect on locomotors system recorded on the days 0, 7, 14, 21 and 28 of experiment

Malabar Secrets: South Indian Muslim Men’s (Homo)sociality across the Indian Ocean.

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External validation and recalibration of an incidental meningioma prognostic model - IMPACT: protocol for an international multicentre retrospective cohort study

Introduction: Due to the increased use of CT and MRI, the prevalence of incidental findings on brain scans is increasing. Meningioma, the most common primary brain tumour, is a frequently encountered incidental finding, with an estimated prevalence of 3/1000. The management of incidental meningioma varies widely with active clinical-radiological monitoring being the most accepted method by clinicians. Duration of monitoring and time intervals for assessment, however, are not well defined. To this end, we have recently developed a statistical model of progression risk based on single-centre retrospective data. The model Incidental Meningioma: Prognostic Analysis Using Patient Comorbidity and MRI Tests (IMPACT) employs baseline clinical and imaging features to categorise the patient with an incidental meningioma into one of three risk groups: low, medium and high risk with a proposed active monitoring strategy based on the risk and temporal trajectory of progression, accounting for actuarial life expectancy. The primary aim of this study is to assess the external validity of this model. Methods and analysis: IMPACT is a retrospective multicentre study which will aim to include 1500 patients with an incidental intracranial meningioma, powered to detect a 10% progression risk. Adult patients ≥16 years diagnosed with an incidental meningioma between 1 January 2009 and 31 December 2010 will be included. Clinical and radiological data will be collected longitudinally until the patient reaches one of the study endpoints: intervention (surgery, stereotactic radiosurgery or fractionated radiotherapy), mortality or last date of follow-up. Data will be uploaded to an online Research Electronic Data Capture database with no unique identifiers. External validity of IMPACT will be tested using established statistical methods. Ethics and dissemination: Local institutional approval at each participating centre will be required. Results of the study will be reported through peer-reviewed articles and conferences and disseminated to participating centres, patients and the public using social media

Search for intermediate-mass black hole binaries in the third observing run of Advanced LIGO and Advanced Virgo

International audienceIntermediate-mass black holes (IMBHs) span the approximate mass range 100−105 M⊙, between black holes (BHs) that formed by stellar collapse and the supermassive BHs at the centers of galaxies. Mergers of IMBH binaries are the most energetic gravitational-wave sources accessible by the terrestrial detector network. Searches of the first two observing runs of Advanced LIGO and Advanced Virgo did not yield any significant IMBH binary signals. In the third observing run (O3), the increased network sensitivity enabled the detection of GW190521, a signal consistent with a binary merger of mass ∼150 M⊙ providing direct evidence of IMBH formation. Here, we report on a dedicated search of O3 data for further IMBH binary mergers, combining both modeled (matched filter) and model-independent search methods. We find some marginal candidates, but none are sufficiently significant to indicate detection of further IMBH mergers. We quantify the sensitivity of the individual search methods and of the combined search using a suite of IMBH binary signals obtained via numerical relativity, including the effects of spins misaligned with the binary orbital axis, and present the resulting upper limits on astrophysical merger rates. Our most stringent limit is for equal mass and aligned spin BH binary of total mass 200 M⊙ and effective aligned spin 0.8 at 0.056 Gpc−3 yr−1 (90% confidence), a factor of 3.5 more constraining than previous LIGO-Virgo limits. We also update the estimated rate of mergers similar to GW190521 to 0.08 Gpc−3 yr−1.Key words: gravitational waves / stars: black holes / black hole physicsCorresponding author: W. Del Pozzo, e-mail: [email protected]† Deceased, August 2020