Analysis of scoliosis trunk deformities using ICA

This paper describes a method for analyzing scoliosis trunk deformities using Independent Component Analysis (ICA). Our hypothesis is that ICA can capture the scoliosis deformities visible on the trunk. Unlike Principal Component Analysis (PCA), ICA gives local shape variation and assumes that the data distribution is not normal. 3D torso images of 56 subjects including 28 patients with adolescent idiopathic scoliosis and 28 healthy subjects are analyzed using ICA. First, we remark that the independent components capture the local scoliosis deformities as the shoulder variation, the scapula asymmetry and the waist deformation. Second, we note that the different scoliosis curve types are characterized by different combinations of specific independent components.CIHR (Canadian Institutes of Health Research

Apprentissage semi-supervisé pour les SVMS et leurs variantes

La reconnaissance de formes est un domaine fort intéressant de l'intelligence artificielle. Pour résoudre les problèmes de reconnaissance de formes, des classifieurs sont construits en utilisant des prototypes de données à reconnaître ainsi que leur classe d'appartenance. On parie d'apprentissage supervisé. Aujourd'hui, face aux importants volumes de données disponibles, le coût de l'étiquetage des données devient très exorbitant. Ainsi, il est impraticable, voir impossible d'étiqueter toutes les données disponibles. Mais puisque, nous savons que la performance d'un classifieur est liée au nombre de données d'apprenfissage, la principale question qui ressort est comment améliorer l'apprentissage d'un classifieur en ajoutant des données non étiquetées à l'ensemble d'apprentissage. La technique d'apprenfissage issue de la réponse à cette quesfion est appelée apprentissage semi- supervisé. La machine à vecteurs de support(SVM) et sa variante Least-Squares SVM (LS-SVM) sont des classifieurs particuliers basés sur le principe de la maximisation de la marge qui leur confère un fort pouvoir de généralisation. Au cours de nos travaux de recherche, nous avons considéré l'apprentissage semi-supervisé de ces machines. Dès lors, nous avons proposé diverses techniques d'apprentissage de ces machines pour accomplir cette tâche. Dans un premier temps, nous avons ufilisé l'inférence bayésienne pour estimer les paramètres du modèle et les étiquettes. Ainsi, nous avons élaboré des formulations bayésiennes à un et deux niveau(x) d'inférence, qui sont par la suite appliquées aux SVMs et aux LS-SVMs dans le contexte de l'apprentissage semi-supervisé. Dans un second temps, nous avons proposé d'améliorer la technique d'auto-apprentissage, en utilisant un classifieur d'approche générative pour aider le principal classifieur discriminant entraîné en semi-supervisé à étiqueter les données. Nous nommons cette stratégie Apprentissage soutenu (Help-Training), et nous l'avons appliqué avec succès aux SVMs et à sa variante LS-SVM. Nos divers algorithmes d'apprentissage semi-supervisé ont été testés sur des données artificielles et réelles et ont donné des résultats encourageants. Cette validation a été appuyée par une analyse montrant les avantages et les limites de chacun des méthodes développées

Non invasive classification system of scoliosis curve types using least-squares support vector machines

Objective To determine scoliosis curve types using non invasive surface acquisition, without prior knowledge from X-ray data. Methods Classification of scoliosis deformities according to curve type is used in the clinical management of scoliotic patients. In this work, we propose a robust system that can determine the scoliosis curve type from non invasive acquisition of the 3D back surface of the patients. The 3D image of the surface of the trunk is divided into patches and local geometric descriptors characterizing the back surface are computed from each patch and constitute the features. We reduce the dimensionality by using principal component analysis and retain 53 components using an overlap criterion combined with the total variance in the observed variables. In this work, a multi-class classifier is built with least-squares support vector machines (LS-SVM). The original LS-SVM formulation was modified by weighting the positive and negative samples differently and a new kernel was designed in order to achieve a robust classifier. The proposed system is validated using data from 165 patients with different scoliosis curve types. The results of our non invasive classification were compared with those obtained by an expert using X-ray images. Results The average rate of successful classification was computed using a leave-one-out cross-validation procedure. The overall accuracy of the system was 95%. As for the correct classification rates per class, we obtained 96%, 84% and 97% for the thoracic, double major and lumbar/thoracolumbar curve types, respectively. Conclusion This study shows that it is possible to find a relationship between the internal deformity and the back surface deformity in scoliosis with machine learning methods. The proposed system uses non invasive surface acquisition, which is safe for the patient as it involves no radiation. Also, the design of a specific kernel improved classification performance.IRSC / CIH

Scoliosis Follow-Up Using Noninvasive Trunk Surface Acquisition

Adolescent idiopathic scoliosis (AIS) is a musculoskeletal pathology. It is a complex spinal curvature in a 3-D space that also affects the appearance of the trunk. The clinical follow-up of AIS is decisive for its management. Currently, the Cobb angle, which is measured from full spine radiography, is the most common indicator of the scoliosis progression. However, cumulative exposure to X-rays radiation increases the risk for certain cancers. Thus, a noninvasive method for the identification of the scoliosis progression from trunk shape analysis would be helpful. In this study, a statistical model is built from a set of healthy subjects using independent component analysis and genetic algorithm. Based on this model, a representation of each scoliotic trunk from a set of AIS patients is computed and the difference between two successive acquisitions is used to determine if the scoliosis has progressed or not. This study was conducted on 58 subjects comprising 28 healthy subjects and 30 AIS patients who had trunk surface acquisitions in upright standing posture. The model detects 93% of the progressive cases and 80% of the nonprogressive cases. Thus, the rate of false negatives, representing the proportion of undetected progressions, is very low, only 7%. This study shows that it is possible to perform a scoliotic patient's follow-up using 3-D trunk image analysis, which is based on a noninvasive acquisition technique.IRSC / CIH

Towards Non Invasive Diagnosis of Scoliosis Using Semi-supervised Learning Approach

Collection : Lecture notes in computer science ; vol. 6112In this paper, a new methodology for the prediction of scoliosis curve types from non invasive acquisitions of the back surface of the trunk is proposed. One hundred and fifty-nine scoliosis patients had their back surface acquired in 3D using an optical digitizer. Each surface is then characterized by 45 local measurements of the back surface rotation. Using a semi-supervised algorithm, the classifier is trained with only 32 labeled and 58 unlabeled data. Tested on 69 new samples, the classifier succeeded in classifying correctly 87.0% of the data. After reducing the number of labeled training samples to 12, the behavior of the resulting classifier tends to be similar to the reference case where the classifier is trained only with the maximum number of available labeled data. Moreover, the addition of unlabeled data guided the classifier towards more generalizable boundaries between the classes. Those results provide a proof of feasibility for using a semi-supervised learning algorithm to train a classifier for the prediction of a scoliosis curve type, when only a few training data are labeled. This constitutes a promising clinical finding since it will allow the diagnosis and the follow-up of scoliotic deformities without exposing the patient to X-ray radiations.CIHR / IRS

Optimisation de ressources pour la sélection de modèle des SVM

La sélection de modèle, optimisation des hyper-paramètres, est une étape très importante pour garantir une forte performance aux SVM. Les méthodes de sélection de modèle automatique nécessitent l'inversion de la matrice de Gram-Schmidt ou la résolution d'un problème d'optimisation quadratique supplémentaire, ce qui est très coûteux en temps de calcul et en mémoire lorsque la taille de l'ensemble d'apprentissage devient importante. Dans ce mémoire, nous proposons une méthode rapide basée sur une approximation du gradient de l'erreur empirique avec une technique d'apprentissage incrémental; ce qui réduit les ressources requises en termes de temps de calcul et d'espace mémoire. Notre méthode testée sur des bases de données synthétiques et réelles a produit des résultats probants confirmant notre approche. Nous avons aussi développé une nouvelle expression pour les SVM avec la formulation de la marge molle «soft margin» L1, ce qui permet d'inclure l'hyper-paramètre C dans les paramètres du noyau

Scoliosis curve type classification from 3D trunk image

Adolescent idiopathic scoliosis (AIS) is a deformity of the spine manifested by asymmetry and deformities of the external surface of the trunk. Classification of scoliosis deformities according to curve type is used to plan management of scoliosis patients. Currently, scoliosis curve type is determined based on X-ray exam. However, cumulative exposure to X-rays radiation significantly increases the risk for certain cancer. In this paper, we propose a robust system that can classify the scoliosis curve type from non invasive acquisition of 3D trunk surface of the patients. The 3D image of the trunk is divided into patches and local geometric descriptors characterizing the surface of the back are computed from each patch and forming the features. We perform the reduction of the dimensionality by using Principal Component Analysis and 53 components were retained. In this work a multi-class classifier is built with Least-squares support vector machine (LS-SVM) which is a kernel classifier. For this study, a new kernel was designed in order to achieve a robust classifier in comparison with polynomial and Gaussian kernel. The proposed system was validated using data of 103 patients with different scoliosis curve types diagnosed and classified by an orthopedic surgeon from the X-ray images. The average rate of successful classification was 93.3% with a better rate of prediction for the major thoracic and lumbar/thoracolumbar types.IRSC / CIH

Prediction of scoliosis curve type based on the analysis of trunk surface topography

Scoliosis treatment strategy is generally chosen according to the severity and type of the spinal curve. Currently, the curve type is determined from X-rays whose acquisition can be harmful for the patient. We propose in this paper a system that can predict the scoliosis curve type based on the analysis of the surface of the trunk. The latter is acquired and reconstructed in 3D using a non invasive multi-head digitizing system. The deformity is described by the back surface rotation, measured on several cross-sections of the trunk. A classifier composed of three support vector machines was trained and tested using the data of 97 patients with scoliosis. A prediction rate of 72.2% was obtained, showing that the use of the trunk surface for a high-level scoliosis classification is feasible and promising.CIHR / IRS

An Application of Using Support Vector Machine Based on Classification Technique for Predicting Medical Data Sets

© 2019, Springer Nature Switzerland AG. This paper illustrates the utilise of various kind of machine learning approaches based on support vector machines for classifying Sickle Cell Disease data set. It has demonstrated that support vector machines generate an essential enhancement when applied for the pre-processing of clinical time-series data set. In this aspect, the objective of this study is to present discoveries for a number of classes of approaches for therapeutically associated problems in the purpose of acquiring high accuracy and performance. The primary case in this study includes classifying the dosage necessary for each patient individually. We applied a number of support vector machines to examine sickle cell data set based on the performance evaluation metrics. The result collected from a number of models have indicated that, support vector Classifier demonstrated inferior outcomes in comparison to Radial Basis Support Vector Classifier. For our Sickle cell data sets, it was found that the Parzen Kernel Support Vector Classifier produced the highest levels of performance and accuracy during training procedure accuracy 0.89733, AUC 0.94267. Where the testing set process, accuracy 0.81778, the area under the curve with 0.86556