Forbidden Landscape from Holography

We present a class of field configurations that are forbidden in the quantum gravity because of inconsistency in the dual field theory from holography. Scale invariant but non-conformal field theories are impossible in (1+1) dimension, and so should be the corresponding gravity dual. In particular, the "spontaneous Lorentz symmetry breaking" models and the "ghost condensation" models, which are well-studied in phenomenology literatures, are forbidden in any consistent quantum theories of gravity in (1+2) dimension since they predict such inconsistent field configurations.Comment: 4pages, v2: some improvements, reference adde

Tachyons in Compact Spaces

We discuss condensations of closed string tachyons localized in compact spaces. Time evolution of an on-shell condensation is naturally related to the worldsheet RG flow. Some explicit tachyonic compactifications of Type II string theory is considered, and some of them are shown to decay into supersymmetric theories known as the little string theories.Comment: 14 page

Localized tachyon condensation and G-parity conservation

We study the condensation of localized tachyon in non-supersymmetric orbifold {\C^2/\Z_n}. We first show that the G-parities of chiral primaries are preserved under the condensation of localized tachyon(CLT) given by the chiral primaries. Using this, we finalize the proof of the conjecture that the lowest-tachyon-mass-squared increases under CLT at the level of type II string with full consideration of GSO projection. We also show the equivalence between the $G$-parity given by $G=[jk_1/n]+ [jk_2/n]$ coming from partition function and that given by $G=\{jk_1/n\}k_2 -\{jk_2/n\}k_1$ coming from the monomial construction for the chiral primaires in the dual mirror picture.Comment: 12 pages, 2 figures, final form to appear in JHE

Characterization of a novel zebrafish (Danio rerio) gene, wdr81, associated with cerebellar ataxia, mental retardation and dysequilibrium syndrome (CAMRQ)

Background: WDR81 (WD repeat-containing protein 81) is associated with cerebellar ataxia, mental retardation and disequilibrium syndrome (CAMRQ2, [MIM 610185]). Human and mouse studies suggest that it might be a gene of importance during neurodevelopment. This study aimed at fully characterizing the structure of the wdr81 transcript, detecting the possible transcript variants and revealing its expression profile in zebrafish, a powerful model organism for studying development and disease. Results: As expected in human and mouse orthologous proteins, zebrafish wdr81 is predicted to possess a BEACH (Beige and Chediak-Higashi) domain, a major facilitator superfamily domain and WD40-repeats, which indicates a conserved function in these species. We observed that zebrafish wdr81 encodes one open reading frame while the transcript has one 5' untranslated region (UTR) and the prediction of the 3' UTR was mainly confirmed along with a detected insertion site in the embryo and adult brain. This insertion site was also found in testis, heart, liver, eye, tail and muscle, however, there was no amplicon in kidney, intestine and gills, which might be the result of possible alternative polyadenylation processes among tissues. The 5 and 18 hpf were critical timepoints of development regarding wdr81 expression. Furthermore, the signal of the RNA probe was stronger in the eye and brain at 18 and 48 hpf, then decreased at 72 hpf. Finally, expression of wdr81 was detected in the adult brain and eye tissues, including but not restricted to photoreceptors of the retina, presumptive Purkinje cells and some neurogenic brains regions. Conclusions: Taken together these data emphasize the importance of this gene during neurodevelopment and a possible role for neuronal proliferation. Our data provide a basis for further studies to fully understand the function of wdr81. © 2015 Doldur-Balli et al

Anisotropic flows from initial state of a fast nucleus

We analyze azimuthal anisotropy in heavy ion collisions related to the reaction plane in terms of standard reggeon approach and find that it is nonzero even when the final state interaction is switched off. This effect can be interpreted in terms of partonic structure of colliding nuclei. We use Feynman diagram analysis to describe details of this mechanism. Main qualitative features of the appropriate azimuthal correlations are discussed.Comment: 16 pages, 11 figures. This paper is an extended version of a talk given at Session of Nuclear Physics Division of Russian Academy of Sciences in November 200

Bulk perturbations of N=2 branes

The evolution of supersymmetric A-type D-branes under the bulk renormalization group flow between two different N=2 minimal models is studied. Using the Landau-Ginzburg description we show that a specific set of branes decouples from the infrared theory, and we make detailed predictions for the behavior of the remaining branes. The Landau-Ginzburg picture is then checked against a direct conformal field theory analysis. In particular we construct a natural index pairing which is preserved by the RG flow, and show that the branes that decouple have vanishing index with the surviving branes.Comment: 35 pages (30 pages plus title and references), 8 figure

Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/β4GalNT2 genes

Background Simultaneous inactivation of pig GGTA1 and CMAH genes eliminates carbohydrate xenoantigens recognized by human antibodies. The β4GalNT2 glycosyltransferase may also synthesize xenoantigens. To further characterize glycan-based species incompatibilities, we examined human and non-human primate antibody binding to cells derived from genetically modified pigs lacking these carbohydrate-modifying genes. Methods The Cas9 endonuclease and gRNA were used to create pigs lacking GGTA1, GGTA1/CMAH, or GGTA1/CMAH/β4GalNT2 genes. Peripheral blood mononuclear cells were isolated from these animals and examined for binding to IgM and IgG from humans, rhesus macaques, and baboons. Results Cells from GGTA1/CMAH/β4GalNT2 deficient pigs exhibited reduced human IgM and IgG binding compared to cells lacking both GGTA1 and CMAH. Nonhuman primate antibody reactivity with cells from the various pigs exhibited a slightly different pattern of reactivity than that seen in humans. Simultaneous inactivation of the GGTA1 and CMAH genes increased nonhuman primate antibody binding compared to cells lacking either GGTA1 only or to those deficient in GGTA1/CMAH/β4GalNT2. Conclusions Inactivation of the β4GalNT2 gene reduces human and nonhuman primate antibody binding resulting in diminished porcine xenoantigenicity. The increased humoral immunity of nonhuman primates towards GGTA1/CMAH-deficient cells compared to pigs lacking either GGTA1 or GGTA1/CMAH/β4GalNT2 highlights the complexities of carbohydrate xenoantigens and suggests potential limitations of the nonhuman primate model for examining some genetic modifications. The progressive reduction of swine xenoantigens recognized by human immunoglobulin through inactivation of pig GGTA1/CMAH/β4GalNT2 genes demonstrates that the antibody barrier to xenotransplantation can be minimized by genetic engineering

The abelian cosets of the Heisenberg group

In this paper we study the abelian cosets of the H(4) WZW model. They coincide or are related to several interesting three-dimensional backgrounds such as the Melvin model, the conical point-particle space-times and the null orbifold. We perform a detailed CFT analysis of all the models and compute the coset characters as well as some typical three-point couplings of coset primaries.Comment: 26 pages; v2: minor typos corrected, also added section 3.3 and 4.3 with a few comments on a third class of geometries that have not been discussed in v