Lung transplantation: Chronic allograft dysfunction and establishing immune tolerance

Despite significant medical advances since the advent of lung transplantation, improvements in long-term survival have been largely unrealized. Chronic lung allograft dysfunction, in particular obliterative bronchiolitis, is the primary limiting factor. The predominant etiology of obliterative bronchiolitis involves the recipient’s innate and adaptive immune response to the transplanted allograft. Current therapeutic strategies have failed to provide a definitive treatment paradigm to improve long-term outcomes. Inducing immune tolerance is an emerging therapeutic strategy that abrogates allograft rejection, avoids immunosuppression, and improves long-term graft function. The aim of this review is to discuss the key immunologic components of obliterative bronchiolitis, describe the state of establishing immune tolerance in transplantation, and highlight those strategies being evaluated in lung transplantation

Antimicrobial pattern of Ricinus communis crude extracts on bacteria isolated from Musa parasidica

This research was done to determine the antimicrobial activity of castor oil plant parts (seed and leaves) on spoilage microorganisms of plantain fruits and vis-a-vis standard antibiotics. Plantain fruits were subjected to spoilage for 7days.The spoilage bacteria were characterized and identified using conventional and modern methods. The organisms isolated include: Corynabacterium sp., Staphylococus aureus and Proteus vulgaris. Castor oil plant (Ricinus communis) leaf and seed were extracted using ethanol and water. The phytochemical analysis of plant extracts were also carried out. The antimicrobial activities of the ethanol and aqueous extracts were tested on the isolates at different concentrations (100mg/ml, 150mg/ml, 200mg/ml and 250mg/ml). The extracts were effective on the bacterial isolates with range of Minimum inhibitory concentration (MIC) values from 25.0mg/ml -100.0mg/ml, Staphylococcus aureus at 12.5mg/ml – 100mg/ml and Proteus vulgaris at 50mg/ml- 100mg/ml. The aqueous extracts of the leaf inhibited Corynabacterium sp., and Staphylococcus aureus but it did not inhibit Proteus vulgaris. Proteus vulgaris was also not inhibited by the aqueous seed extract, Corynabacterium sp. and Staphylococcus aureus were inhibited only at higher concentrations. Antibiotic susceptibility test showed that Corynabacterium sp., was inhibited more by the ethanolic seed extract than it was inhibited by Amoxicillin at the same concentration of 250mg/ml

Current control of grid connected three phase current source inverter based on medium power renewable energy system

Current source inverter (CSI) features simple converter structure and inherent voltage boost capability. In addition, it provides low instantaneous rate of voltage change with respect to time in comparison to voltage source inverter (VSI) and multilevel inverter (MLI). Nonetheless, CSI does not outshine as grid interfacing unit in photovoltaic (PV) generation system. This is because of requirement of large sizing of dc-link inductor and sluggish performance during light load condition. Contemplating both advantages and disadvantages of CSI, this work is aimed to investigate and analyze the superiority of CSI in PV system. The proposed system employs direct regular-sampled pulse width modulation (DRSPWM) as modulator and multi-loop proportional-integral (PI) in synchronous frame as the controller. The grid-connected CSI system is further evaluated along with photovoltaic maximum power point tracking (PV-MPPT) control. Simulation verification highlighted that the option of using CSI as medium power PV grid integration unit in exchanging active-reactive power with grid network is very satisfactory. In addition, balanced sinusoidal output currents with acceptable harmonic limit are successfully achieved; like other topologies in PV grid integration. The proposed CSI system is proved to be able to track the references in event of varying input condition from PV array. The theoretical equations and modeling are described, and the simulation are conducted in MATLAB / Simulink platform

Enhanced mesoscopic fluctuations in the crossover between random matrix ensembles

In random-matrix ensembles that interpolate between the three basic ensembles (orthogonal, unitary, and symplectic), there exist correlations between elements of the same eigenvector and between different eigenvectors. We study such correlations, using a remarkable correspondence between the interpolating ensembles late in the crossover and a basic ensemble of finite size. In small metal grains or semiconductor quantum dots, the correlations between different eigenvectors lead to enhanced fluctuations of the electron-electron interaction matrix elements which become parametrically larger than the non-universal fluctuations.Comment: 4 pages, RevTeX; 3 figure

Universal Features of Holographic Anomalies

We study the mechanism by which gravitational actions reproduce the trace anomalies of the holographically related conformal field theories. Two universal features emerge: a) the ratios of type B trace anomalies in any even dimension are independent of the gravitational action, being uniquely determined by the underlying algebraic structure b) the normalization of the type A and the overall normalization of the type B anomalies are given by action dependent expressions with the dimension dependence completely fixed.Comment: 17 pages, harvma

Wavefunction statistics in open chaotic billiards

We study the statistical properties of wavefunctions in a chaotic billiard that is opened up to the outside world. Upon increasing the openings, the billiard wavefunctions cross over from real to complex. Each wavefunction is characterized by a phase rigidity, which is itself a fluctuating quantity. We calculate the probability distribution of the phase rigidity and discuss how phase rigidity fluctuations cause long-range correlations of intensity and current density. We also find that phase rigidities for wavefunctions with different incoming wave boundary conditions are statistically correlated.Comment: 4 pages, RevTeX; 1 figur

Spin magnetization of strongly correlated electron gas confined in a two-dimensional finite lattice

The influence of disorder and interaction on the ground state polarization of the two-dimensional (2D) correlated electron gas is studied by numerical investigations of unrestricted Hartree-Fock equations. The ferromagnetic ground state is found to be plausible when the electron number is lowered and the interaction and disorder parameters are suitably chosen. For a finite system at constant electronic density the disorder induced spin polarization is cut off when the electron orbitals become strongly localized to the individual network sites. The fluctuations of the interaction matrix elements are calculated and brought out as favoring the ferromagnetic instability in the extended and weak localization regime. The localization effect of the Hubbard interaction term is discussed.Comment: 7 pages, 9 figure

On the fourth-order accurate compact ADI scheme for solving the unsteady Nonlinear Coupled Burgers' Equations

The two-dimensional unsteady coupled Burgers' equations with moderate to severe gradients, are solved numerically using higher-order accurate finite difference schemes; namely the fourth-order accurate compact ADI scheme, and the fourth-order accurate Du Fort Frankel scheme. The question of numerical stability and convergence are presented. Comparisons are made between the present schemes in terms of accuracy and computational efficiency for solving problems with severe internal and boundary gradients. The present study shows that the fourth-order compact ADI scheme is stable and efficient

O adsorption and incipient oxidation of the Mg(0001) surface

First principles density functional calculations are used to study the early oxidation stages of the Mg(0001) surface for oxygen coverages 1/16 <= Theta <= 3 monolayers. It is found that at very low coverages O is incorporated below the topmost Mg layer in tetrahedral sites. At higher oxygen-load the binding in on-surface sites is increased but at one monolayer coverage the on-surface binding is still about 60 meV weaker than for subsurface sites. The subsurface octahedral sites are found to be unfavorable compared to subsurface tetrahedral sites and to on-surface sites. At higher coverages oxygen adsorbs both under the surface and up. Our calculations predict island formation and clustering of incorporated and adsorbed oxygen in agreement with previous calculations. The calculated configurations are compared with the angle-scanned x-ray photoelectron diffraction experiment to determine the geometrical structure of the oxidized Mg(0001) surface.Comment: 10 pages, 5 figure

Magnetotransport in two-dimensional electron gas at large filling factors

We derive the quantum Boltzmann equation for the two-dimensional electron gas in a magnetic field such that the filling factor $\nu \gg 1$. This equation describes all of the effects of the external fields on the impurity collision integral including Shubnikov-de Haas oscillations, smooth part of the magnetoresistance, and non-linear transport. Furthemore, we obtain quantitative results for the effect of the external microwave radiation on the linear and non-linear $dc$ transport in the system. Our findings are relevant for the description of the oscillating resistivity discovered by Zudov {\em et al.}, zero-resistance state discovered by Mani {\em et al.} and Zudov {\em et al.}, and for the microscopic justification of the model of Andreev {\em et al.}. We also present semiclassical picture for the qualitative consideration of the effects of the applied field on the collision integral.Comment: 28 pages, 19 figures; The discussion of the role of the effect of the microwave field on the distribution function is revised (see also cond-mat/0310668). Accepted in Phys. Rev.