Whole body vibration training and its application to age-related performance decrements:an exploratory analysis

Middle age is associated with a pronounced decline in power and flexibility. Whilst whole body vibration training (WBVT) improves performance in a range of populations, whether WBVT can improve muscle power and flexibility in a middle-aged population is not known. The present study aimed to determine the influence of 5 weeks progressive WBVT in middle-aged (45-55 yrs.) and younger (20-30 yrs.) recreationally active females. Participants in each age group were randomly allocated to an intervention (WBVT) or control group. The WBVT groups trained for five weeks on a vibration platform, while the control groups performed identical exercises, with no vibration. Prior to, and after, the five-week study vertical countermovement jump (VCMJ) and range of motion (ROM) performance were measured. WBVT significantly (P = 0.001) improved VCMJ performance when compared to the control groups. This improvement was significantly (P = 0.001) greater in the middle-aged compared with the younger WBVT group. WBVT significantly (P = 0.001) improved ROM irrespective of age. Taken together, these results suggest that WBVT can off-set age related performance decrements, which has therapeutic implications for musculoskeletal aging. Therefore, WBVT could be undertaken to minimise age-related performance deterioration in middle-aged female populations

Multi-wavelength analysis of the Galactic supernova remnant MSH 11-61A

Due to its centrally bright X-ray morphology and limb brightened radio profile, MSH 11-61A (G290.1-0.8) is classified as a mixed morphology supernova remnant (SNR). H\textsc{i} and CO observations determined that the SNR is interacting with molecular clouds found toward the north and southwest regions of the remnant. In this paper we report on the detection of $\gamma$-ray emission coincident with MSH 11-61A, using 70 months of data from the Large Area Telescope on board the \textit{Fermi Gamma-ray Space Telescope}. To investigate the origin of this emission, we perform broadband modelling of its non-thermal emission considering both leptonic and hadronic cases and concluding that the $\gamma$-ray emission is most likely hadronic in nature. Additionally we present our analysis of a 111 ks archival \textit{Suzaku} observation of this remnant. Our investigation shows that the X-ray emission from MSH 11-61A arises from shock-heated ejecta with the bulk of the X-ray emission arising from a recombining plasma, while the emission towards the east arises from an ionising plasma.Comment: 12 Pages, 8 figures. Accepted for publication in the Astrophysical Journa

School Violence Prevention: Teachers Establishing Relationships With Students Using Counseling Strategies

Although youth violence rates continue to decrease in the United States, it remains the second leading cause of death for adolescents. Furthermore, school violence remains a sociocultural concern, especially due to increasing media attention. Research consistently indicates that preventing school violence involves measures that go beyond formal protocols. One factor that has emerged from this research is that the quality of relationships between students and teachers, commonly referred to as school connectedness, may have a significant role in preventing school violence. However, there is very little literature that addresses how mental health professionals, such as school counselors, can assist teachers in fostering school connectedness with their students. This article provides a theoretical conceptualization of teacher–student relationship and communication skills that contribute to eventual school violence prevention through the development of school connectedness. The ultimate goal of this theoretical model is to provide conceptual and applied guidance in bridging the gap between research and practice

The effect of running nine marathons in nine days on proprioception and balance

Background: Multi-day running events are becoming increasingly popular with nonprofessional athletes. However, it is unknown how and when this type of event affects injury risk factors such as proprioception and balance. Objective: To evaluate the effect of running one, five consecutive and nine consecutive marathons on joint position sense (JPS) and dynamic balance. Design: Cross-sectional, observational study. Setting: Sports-injury clinic. Participants: 21 athletes completing the event (age 44.8±8.09 yrs, mass 74.4±13.14 kg, years running 10.4±7.39 yrs, average weekly mileage 44.8±12.09 miles) entered the study. Ten athletes completed the JPS testing and five athletes completed the dynamic balance testing. Assessment of Risk Factors: Risk factors were assessed the day before the event (day zero) and then following completion of one (day one), five (day five) and nine (day nine) consecutive marathons. The independent variable was time. Main Outcome Measurements: JPS error into flexion and extension, star-excursion balance test (SEBT) and number of injuries per runner. Results: Friedman's ANOVAs indicated no effects of time on JPS into extension (p=0.94), dominant-leg anterior (p=0.52) or posterior-lateral (p=0.65) SEBT reach. JPS flexion error significantly decreased by 1.3° from day one to five (p=0.032). Non-dominant leg anterior, posterior-medial and posterior-lateral SEBT reaches significantly decreased from day zero to nine by 0.09% (p=0.043), 0.13% (p=0.043) and 0.17% (p=0.043) of leg length respectively. Dominant leg posterior-medial SEBT reach also significantly decreased by 0.12% of leg length (p=0.043) from day zero to nine. There were 4.2 injuries per runner. Conclusions: The results suggest multi-day running events can cause over four lower limb injuries per runner and reduce dynamic balance ability. Nonprofessional athletes completing these events should be aware of this high injury occurrence and prepare appropriately. Injury prevention programmes incorporating dynamic balance may be recommended. However future studies with additional risk factors and larger sample sizes are needed to substantiate these findings

Rethinking Visual Communication Curriculum: The Success of Emporium Style

The College of Journalism and Mass Communications faced challenges with budget and faculty resources causing a bottleneck, in the beginning, visual communications courses for the College. In the fall of 2016, a solution was implemented in the form of an emporium style teaching model, where students can seek help on projects and collaborate with peers on projects. The program is the first-of-its-kind giving students experience with the technologies and techniques needed to be powerful and effective storytellers. Students leverage the technology they use in their daily lives to solve real-world problems, with the help of faculty available in a learning resource center. Topic-based workshops and boot camps offer students additional hands-on learning experiences with the software. The program\u27s first students finished in Spring 2017 with positive results to date. Participants will take away ideas, materials, lessons around organizing, teaching, and assessing a course of this nature

Crystal polymorphism in a carbamazepine derivative: Oxcarbazepine

Although crystal polymorphism of carbamazepine (CBZ), an anticonvulsant used to treat epilepsy, has been known for decades, the phenomenon has only recently been noted for its keto-derivative oxcarbazepine (OCB). Here it is demonstrated that OCB possesses at least three anhydrous polymorphs. Although all forms are morphologically similar, making differentiation between crystal modifications by optical microscopy difficult, powder X-ray diffraction, Raman spectroscopy, and thermomicroscopy show distinctive differences. These techniques provide an efficient method of distinguishing between the three polymorphs. The crystal structure of form II of OCB is reported for the first time and the structure of form I has been redetermined at low temperature. Remarkably, both the molecular conformation and crystal packing of form II are in excellent agreement with the blind prediction made in 2007. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 99:794–803, 2010Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/64542/1/21873_ftp.pd

Cutting care clusters: the creation of an inverse pharmacy care law? An area-level analysis exploring the clustering of community pharmacies in England

Objectives To (1) explore the clustering of community pharmacies in England and (2) determine the relationship between community pharmacy clustering, urbanity and deprivation. Design An area-level analysis spatial study. Setting England. Primary and secondary outcome measures Community pharmacy clustering determined as a community pharmacy located within 10 min walking distance to another community pharmacy. Participants Addresses and postal codes of each community pharmacy in England were used in the analysis. Each pharmacy postal code was assigned to a lower layer super output area, which was then matched to urbanity (urban, town and fringe or village, hamlet and isolated dwellings) and deprivation decile (using the Index of Multiple Deprivation score). Results 75% of community pharmacies in England were located in a ‘cluster’ (within 10 min walking distance of another pharmacy): 19% of community pharmacies were in a cluster of two, while 56% of community pharmacies were in clusters of three or more. There was a linear relationship between community pharmacy clustering and social deprivation—with clustering more prevalent in areas of higher deprivation: for community pharmacies located in areas of lowest deprivation (decile 1), there was a significantly lower risk of clustering compared with community pharmacies located in areas of highest deprivation (relative risk 0.12 (95% CI 0.10 to 0.16)). Conclusions Clustering of community pharmacies in England is common, although there is a positive trend between community pharmacy clustering and social deprivation, whereby clustering is more significant in areas of high deprivation. Arrangements for future community pharmacy funding should not solely focus on distance from one pharmacy to another as means of determining funding allocation, as this could penalise community pharmacies in our most deprived communities, and potentially have a negative effect on other healthcare providers, such as general practitioner and accident and emergency services

The role of ‘non-knowledge’ in crisis policymaking: a proposal and agenda for future research

Background:Recent complex and cross-boundary policy problems, such as climate change, pandemics, and financial crises, have recentred debates about state capacity, democratic discontent and the ‘crisis of expertise’. These problems are contested and open to redefinition, misunderstanding, spin, and deception, challenging the ability of policymakers to locate, discriminate, comprehend, and respond to competing sources of knowledge and expertise. We argue that ‘non-knowledge’ is an under-explored aspect of responses to major policy crises.Key points:While discussed in recent work in sociology and other social sciences, non-knowledge has been given less explicit attention in policy studies, and is not fully captured by orthodox understandings of knowledge and evidence use. We outline three main forms of non-knowledge that challenge public agencies: amnesia, ignorance and misinformation. In each case, ‘non-knowledge’ is not simply the absence of policy-relevant knowledge. Amnesia refers to what is forgotten, reinvented or ‘unlearned’, while claims of ignorance involve obscuring or casting aside of relevant knowledge that could (or even should) be available. To be misinformed is to actively believe false or misleading information. In each instance, non-knowledge may have strategic value for policy actors or aid the pursuit of self-interest.Conclusions and implications:We demonstrate the relevance of non-knowledge through a brief case study, emerging from the inquiry into the COVID-19 hotel quarantine programme in the Australian state of Victoria. We argue that both amnesia and ‘practical’ forms of ignorance contributed to failures during the early part of the programme

Serotonin signaling through the 5-HT1B receptor and NADPH oxidase 1 in pulmonary arterial hypertension

Objective: Serotonin can induce human pulmonary artery smooth muscle cell (hPASMC) proliferation through reactive oxygen species (ROS), influencing the development of pulmonary arterial hypertension (PAH). We hypothesise that in PASMCs, serotonin induces oxidative stress through NADPH-oxidase-derived ROS generation and reduced Nrf-2 anti-oxidant systems, promoting vascular injury. Approach and Results: HPASMCs from controls and PAH patients, and PASMCs from Nox1-/- mice, were stimulated with serotonin in the absence/presence of inhibitors of Src kinase, the 5-HT1B receptor and NADPH oxidase 1 (Nox1). Markers of fibrosis were also determined. The pathophysiological significance of our findings was examined in vivo in serotonin transporter overexpressing (SERT+) female mice, a model of pulmonary hypertension (PH). We confirmed serotonin increased superoxide and H2O2 production in these cells. For the first time, we show that serotonin increased oxidized protein tyrosine phosphatases and peroxiredoxin-SO3H and decreased Nrf-2 and catalase activity in hPASMCs. ROS generation was exaggerated, and dependent on c-Src, 5-HT1B receptor and the serotonin transporter in PAH-hPASMCs. Proliferation and extracellular matrix remodeling were exaggerated in PAH-hPASMCs and dependent on 5-HT1B receptor signaling and Nox1, confirmed in PASMCs from Nox1-/- mice. In SERT+ mice, SB216641, a 5-HT1B receptor antagonist, prevented development of PH in a ROS-dependent manner. Conclusions: Serotonin can induce c-Src-regulated Nox1-induced ROS and Nrf-2 dysregulation, contributing to increased post-translational oxidative modification of proteins, activation of redox-sensitive signaling pathways in hPASMCs; associated with mitogenic responses. 5-HT1B receptors contribute to experimental PH by inducing lung ROS production. Our results suggest 5-HT1B receptor-dependent c-Src-Nox1-pathways contribute to vascular remodeling in PAH