6,079 research outputs found
Soluble Fermentable Dietary Fibre (Pectin) Decreases Caloric Intake, Adiposity and Lipidaemia in High-Fat Diet-Induced Obese Rats
Funding: This work was funded by the Scottish Government Rural and Environment Science and Analytical Services Division. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD
Dose-dependent effects of a soluble dietary fibre (pectin) on food intake, adiposity, gut hypertrophy and gut satiety hormone secretion in rats
Acknowledgments We thank Donna Wallace and Animal House staff at the Rowett Institute of Nutrition and Health for the daily care of experimental rats and for the body weight, food intake and MRI measurements.Peer reviewedPublisher PD
Different types of soluble fermentable dietary fibre decrease food intake, body weight gain and adiposity in young adult male rats
We thank Donna Wallace and the Rowett Animal House staff for the daily care of experimental rats, body weight and food intake measurements and MRI scanning, Vivien Buchan and Donna Henderson of the Rowett Analytical Department for proximate analyses and SCFA GC, and Andrew Chappell for conducting the beta-glucan analysis. This research was funded by the Scottish Government’s Rural and Environment Science and Analytical Services Division.Peer reviewedPublisher PD
Undernutrition and stage of gestation influence fetal adipose tissue gene expression
Funded by the Scottish Government’s Rural and Environment Science and Analytical Services Division (RESAS), including the Strategic Partnership for Animal Science Excellence (SPASE) and the U.S. National Institutes of Health (HD045784). None of the authors had any financial or personal conflicts of interest.Peer reviewedPostprin
Complex functional surface design for additive manufacturing
This paper presents a new methodology for the creation of advanced surfaces which can be produced by Additive Manufacturing (AM) methods. Since there is no cost for enhanced complexity, AM allows for new capabilities in surface design. Micro-scale surface features with varying size, shape and pitch can be manufactured by Two-Photon Polymerisation (2PP). Computer-Aided Design (CAD) tools allowing for this variation to be incorporated into the surface design are only just emerging. With the presented methodology, surfaces are created from a single feature design. Variation is applied to the surface features through algorithmic design tools, allowing for arrays of hundreds of unique features can be created by non-CAD experts. The translation of these algorithmic expressions from CAD to a physical surface is investigated. Using the proposed methodology, 2PP is used to create quasi stochastic surfaces for the purpose of enhancing the biointegration of medical implants against current state-of-the-art
Ovine prenatal growth-restriction and sex influence fetal adipose tissue phenotype and impact postnatal lipid metabolism and adiposity in vivo from birth until adulthood
Funding: This work was funded by the Scottish Government’s Rural and Environmental Science and Analytical Services Division (RESAS) including the Strategic Partnership for Animal Science. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD
Gas Kinematics on GMC scales in M51 with PAWS: cloud stabilization through dynamical pressure
We use the high spatial and spectral resolution of the PAWS CO(1-0) survey of
the inner 9 kpc of the iconic spiral galaxy M51 to examine the effect of gas
streaming motions on the star-forming properties of individual GMCs. We compare
our view of gas flows in M51 -- which arise due to departures from axi-symmetry
in the gravitational potential (i.e. the nuclear bar and spiral arms) -- with
the global pattern of star formation as traced by Halpha and 24\mu m emission.
We find that the dynamical environment of GMCs strongly affects their ability
to form stars, in the sense that GMCs situated in regions with large streaming
motions can be stabilized, while similarly massive GMCs in regions without
streaming go on to efficiently form stars. We argue that this is the result of
reduced surface pressure felt by clouds embedded in an ambient medium
undergoing large streaming motions, which prevents collapse. Indeed, the
variation in gas depletion time expected based on the observed streaming
motions throughout the disk of M51 quantitatively agrees with the variation in
observed gas depletion time scale. The example of M51 shows that streaming
motions, triggered by gravitational instabilities in the form of bars and
spiral arms, can alter the star formation law; this can explain the variation
in gas depletion time among galaxies with different masses and morphologies. In
particular, we can explain the long gas depletion times in spiral galaxies
compared to dwarf galaxies and starbursts. We suggest that adding a dynamical
pressure term to the canonical free-fall time produces a single star formation
law that can be applied to all star-forming regions and galaxies, across cosmic
time.Comment: 28 pages, 14 figures, accepted for publication in Ap
The PdBI Arcsecond Whirlpool Survey (PAWS): Multi-phase cold gas kinematic of M51
The kinematic complexity and the favorable position of M51 on the sky make
this galaxy an ideal target to test different theories of spiral arm dynamics.
Taking advantage of the new high resolution PdBI Arcsecond Whirlpool Survey
(PAWS) data, we undertake a detailed kinematic study of M51 to characterize and
quantify the origin and nature of the non-circular motions. Using a tilted-ring
analysis supported by several other archival datasets we update the estimation
of M51's position angle (PA=(173 +/- 3) deg) and inclination (i=(22 +/- 5)
deg). Harmonic decomposition of the high resolution (40 pc) CO velocity field
shows the first kinematic evidence of an m=3 wave in the inner disk of M51 with
a corotation at R(CR,m=3)=1.1 +/- 0.1 kpc and a pattern speed of Omega_p(m=3) =
140 km/(s kpc). This mode seems to be excited by the nuclear bar, while the
beat frequencies generated by the coupling between the m=3 mode and the main
spiral structure confirm its density-wave nature. We observe also a signature
of an m=1 mode that is likely responsible for the lopsidedness of M51 at small
and large radii. We provide a simple method to estimate the radial variation of
the amplitude of the spiral perturbation (Vsp) attributed to the different
modes. The main spiral arm structure has =50-70 km/s, while the streaming
velocity associated with the m=1 and m=3 modes is, in general, 2 times lower.
Our joint analysis of HI and CO velocity fields at low and high spatial
resolution reveals that the atomic and molecular gas phases respond differently
to the spiral perturbation due to their different vertical distribution and
emission morphology.Comment: 42 pages, 12 figures, accepted for publication in Ap
A Comparative Study of Giant Molecular Clouds in M51, M33 and the Large Magellanic Cloud
We compare the properties of giant molecular clouds (GMCs) in M51 identified
by the Plateau de Bure Interferometer Whirlpool Arcsecond Survey (PAWS) with
GMCs identified in wide-field, high resolution surveys of CO emission in M33
and the Large Magellanic Cloud (LMC). We find that GMCs in M51 are larger,
brighter and have higher velocity dispersions relative to their size than
equivalent structures in M33 and the LMC. These differences imply that there
are genuine variations in the average mass surface density of the different GMC
populations. To explain this, we propose that the pressure in the interstellar
medium surrounding the GMCs plays a role in regulating their density and
velocity dispersion. We find no evidence for a correlation between size and
linewidth in any of M51, M33 or the LMC when the CO emission is decomposed into
GMCs, although moderately robust correlations are apparent when regions of
contiguous CO emission (with no size limitation) are used. Our work
demonstrates that observational bias remains an important obstacle to the
identification and study of extragalactic GMC populations using CO emission,
especially in molecule-rich galactic environments.Comment: 25 pages, 11 figures, accepted for publication in ApJ. Uses
emulateapj LaTeX macros. For more information on PAWS, further papers and
data, see http://www.mpia.de/PAWS
The PdBI Arcsecond Whirlpool Survey (PAWS): Environmental Dependence of Giant Molecular Cloud Properties in M51
Using data from the PdBI Arcsecond Whirlpool Survey (PAWS), we have generated
the largest extragalactic Giant Molecular Cloud (GMC) catalog to date,
containing 1,507 individual objects. GMCs in the inner M51 disk account for
only 54% of the total 12CO(1-0) luminosity of the survey, but on average they
exhibit physical properties similar to Galactic GMCs. We do not find a strong
correlation between the GMC size and velocity dispersion, and a simple virial
analysis suggests that 30% of GMCs in M51 are unbound. We have analyzed the GMC
properties within seven dynamically-motivated galactic environments, finding
that GMCs in the spiral arms and in the central region are brighter and have
higher velocity dispersions than inter-arm clouds. Globally, the GMC mass
distribution does not follow a simple power law shape. Instead, we find that
the shape of the mass distribution varies with galactic environment: the
distribution is steeper in inter-arm region than in the spiral arms, and
exhibits a sharp truncation at high masses for the nuclear bar region. We
propose that the observed environmental variations in the GMC properties and
mass distributions are a consequence of the combined action of large-scale
dynamical processes and feedback from high mass star formation. We describe
some challenges of using existing GMC identification techniques for decomposing
the 12CO(1-0) emission in molecule-rich environments, such as M51's inner disk.Comment: 73 pages, 18 figures, 14 tables, accepted for publication in Ap
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