System design of the Pioneer Venus spacecraft. Volume 2: Science

The objectives of the low-cost Pioneer Venus space probe program are discussed. The space mission and science requirements are analyzed. The subjects considered are as follows: (1) the multiprobe mission, (2) the orbiter mission, (3) science payload accomodations, and (4) orbiter spacecraft experimental interface specifications. Tables of data are provided to show the science allocations for large and small probes. Illustrations of the systems and components of various probe configurations are included

Liquid drop splashing on smooth, rough and textured surfaces

Splashing occurs when a liquid drop hits a dry solid surface at high velocity. This paper reports experimental studies of how the splash depends on the roughness and the texture of the surfaces as well as the viscosity of the liquid. For smooth surfaces, there is a "corona" splash caused by the presence of air surrounding the drop. There are several regimes that occur as the velocity and liquid viscosity are varied. There is also a "prompt" splash that depends on the roughness and texture of the surfaces. A measurement of the size distribution of the ejected droplets is sensitive to the surface roughness. For a textured surface in which pillars are arranged in a square lattice, experiment shows that the splashing has a four-fold symmetry. The splash occurs predominantly along the diagonal directions. In this geometry, two factors affect splashing the most: the pillar height and spacing between pillars.Comment: 9 pages, 11 figure

A note on leapfrogging vortex rings

In this paper we provide examples, by numerical simulation using the Navier-Stokes equations for axisymmetric laminar flow, of the 'leapfrogging' motion of two, initially identical, vortex rings which share a common axis of symmetry. We show that the number of clear passes that each ring makes through the other increases with Reynolds number, and that as long as the configuration remains stable the two rings ultimately merge to form a single vortex ring

Hydrodynamic and magnetohydrodynamic computations inside a rotating sphere

Numerical solutions of the incompressible magnetohydrodynamic (MHD) equations are reported for the interior of a rotating, perfectly-conducting, rigid spherical shell that is insulator-coated on the inside. A previously-reported spectral method is used which relies on a Galerkin expansion in Chandrasekhar-Kendall vector eigenfunctions of the curl. The new ingredient in this set of computations is the rigid rotation of the sphere. After a few purely hydrodynamic examples are sampled (spin down, Ekman pumping, inertial waves), attention is focused on selective decay and the MHD dynamo problem. In dynamo runs, prescribed mechanical forcing excites a persistent velocity field, usually turbulent at modest Reynolds numbers, which in turn amplifies a small seed magnetic field that is introduced. A wide variety of dynamo activity is observed, all at unit magnetic Prandtl number. The code lacks the resolution to probe high Reynolds numbers, but nevertheless interesting dynamo regimes turn out to be plentiful in those parts of parameter space in which the code is accurate. The key control parameters seem to be mechanical and magnetic Reynolds numbers, the Rossby and Ekman numbers (which in our computations are varied mostly by varying the rate of rotation of the sphere) and the amount of mechanical helicity injected. Magnetic energy levels and magnetic dipole behavior are exhibited which fluctuate strongly on a time scale of a few eddy turnover times. These seem to stabilize as the rotation rate is increased until the limit of the code resolution is reached.Comment: 26 pages, 17 figures, submitted to New Journal of Physic

A mechanism for morphogen-controlled domain growth

Many developmental systems are organised via the action of graded distributions of morphogens. In the Drosophila wing disc, for example, recent experimental evidence has shown that graded expression of the morphogen Dpp controls cell proliferation and hence disc growth. Our goal is to explore a simple model for regulation of wing growth via the Dpp gradient: we use a system of reaction-diffusion equations to model the dynamics of Dpp and its receptor Tkv, with advection arising as a result of the flow generated by cell proliferation. We analyse the model both numerically and analytically, showing that uniform domain growth across the disc produces an exponentially growing wing disc

Obesity: A Biobehavioral Point of View

Excerpt: If you ask an overweight person, “Why are you fat?’, you will, almost invariably, get the answer, “Because 1 eat too much.” You will get this answer in spite of the fact that of thirteen studies, six find no significant differences in the caloric intake of obese versus nonobese subjects, five report that the obese eat significantly less than the nonobese, and only two report that they eat significantly more

Regional-Specific Effects of Ovarian Hormone Loss on Synaptic Plasticity in Adult Human APOE Targeted Replacement Mice

The human apolipoprotein ε4 allele (APOE4) has been implicated as one of the strongest genetic risk factors associated with Alzheimer’s disease (AD) and in influencing normal cognitive functioning. Previous studies have demonstrated that mice expressing human apoE4 display deficits in behavioral and neurophysiological outcomes compared to those with apoE3. Ovarian hormones have also been shown to be important in modulating synaptic processes underlying cognitive function, yet little is known about how their effects are influenced by apoE. In the current study, female adult human APOE targeted replacement (TR) mice were utilized to examine the effects of human APOE genotype and long-term ovarian hormone loss on synaptic plasticity in limbic regions by measuring dendritic spine density and electrophysiological function. No significant genotype differences were observed on any outcomes within intact mice. However, there was a significant main effect of genotype on total spine density in apical dendrites in the hippocampus, with post-hoc t-tests revealing a significant reduction in spine density in apoE3 ovariectomized (OVX) mice compared to sham operated mice. There was also a significant main effect of OVX on the magnitude of LTP, with post-hoc t-tests revealing a decrease in apoE3 OVX mice relative to sham. In contrast, apoE4 OVX mice showed increased synaptic activity relative to sham. In the lateral amygdala, there was a significant increase in total spine density in apoE4 OVX mice relative to sham. This increase in spine density was consistent with a significant increase in spontaneous excitatory activity in apoE4 OVX mice. These findings suggest that ovarian hormones differentially modulate synaptic integrity in an apoE-dependent manner within brain regions that are susceptible to neurophysiological dysfunction associated with AD

Long-Term Effects of Chronic Intermittent Ethanol Exposure in Adolescent and Adult Rats: Radial-Arm Maze Performance and Operant Food Reinforced Responding

Background: Adolescence is not only a critical period of late-stage neurological development in humans, but is also a period in which ethanol consumption is often at its highest. Given the prevalence of ethanol use during this vulnerable developmental period we assessed the long-term effects of chronic intermittent ethanol (CIE) exposure during adolescence, compared to adulthood, on performance in the radial-arm maze (RAM) and operant food-reinforced responding in male rats. Methodology/Principal Findings: Male Sprague Dawley rats were exposed to CIE (or saline) and then allowed to recover. Animals were then trained in either the RAM task or an operant task using fixed- and progressive- ratio schedules. After baseline testing was completed all animals received an acute ethanol challenge while blood ethanol levels (BECs) were monitored in a subset of animals. CIE exposure during adolescence, but not adulthood decreased the amount of time that animals spent in the open portions of the RAM arms (reminiscent of deficits in risk-reward ntegration) and rendered animals more susceptible to the acute effects of an ethanol challenge on working memory tasks. The operant food reinforced task showed that these effects were not due to altered food motivation or to differential sensitivity to the nonspecific performance-disrupting effects of ethanol. However, CIE pre-treated animals had lower BEC levels than controls during the acute ethanol challenges indicating persistent pharmacokinetic tolerance to ethanol after the CIE treatment. There was little evidence of enduring effects of CIE alone on traditional measures of spatial and working memory. Conclusions/Significance: These effects indicate that adolescence is a time of selective vulnerability to the long-term effects of repeated ethanol exposure on neurobehavioral function and acute ethanol sensitivity. The positive and negative findings reported here help to further define the nature and extent of the impairments observed after adolescent CIE and provide direction for future research

Disparities in Healthy Food Zoning, Farmers\u27 Market Availability, and Fruit and Vegetable Consumption Among North Carolina Residents

Background: Context and purpose of the study. To examine (1) associations between county-level zoning to support farmers\u27 market placement and county-level farmers\u27 market availability, rural/urban designation, percent African American residents, and percent of residents living below poverty and (2) individual-level associations between zoning to support farmers\u27 markets; fruit and vegetable consumption and body mass index (BMI) among a random sample of residents of six North Carolina (NC) counties. Methods: Zoning ordinances were scored to indicate supportiveness for healthy food outlets. Number of farmers\u27 markets (per capita) was obtained from the NC-Community Transformation Grant Project Fruit and Vegetable Outlet Inventory (2013). County-level census data on rural/urban status, percent African American, and percent poverty were obtained. For data on farmers\u27 market shopping, fruit and vegetable consumption, and BMI, trained interviewers conducted a random digit dial telephone survey of residents of six NC counties (3 urban and 3 rural). Pearson correlation coefficients and multilevel linear regression models were used to examine county-level and individual-level associations between zoning supportiveness, farmers\u27 market availability, and fruit and vegetable consumption and BMI. Results: At the county-level, healthier food zoning was greater in more urban areas and areas with less poverty. At the individual-level, self-reported fruit and vegetable consumption was associated with healthier food zoning. Conclusions: Disparities in zoning to promote healthy eating should be further examined, and future studies should assess whether amending zoning ordinances will lead to greater availability of healthy foods and changes in dietary behavior and health outcomes