PANEL DISCUSSION: SECRETARIAT OF AGRICULTURE, LIVESTOCK AND RURAL DEVELOPMENT, MEXICO

Community/Rural/Urban Development,

STRUCTURAL DEVELOPMENTS IN THE MEXICAN LIVESTOCK SUBSECTOR: THE CASE OF FEEDER CATTLE AND BEEF PRODUCTION

Livestock Production/Industries,

Governance and Environmental Democracy: a Global Policy

In legal terms, and through the late decades sustainable development has transformed from an economic development theory to a public policy obligation that in turn has also translated in practice into concrete rights and obligations in legal systems throughout the world. These rights and obligations apply both to individuals and governments through constitutional, civil, administrative, commercial and even criminal legal rules. Environmental law has become an essential tool for governance and administration of sustainable development while environmental democracy and its elements are becoming essential for a safe and sound planetary cohabitation. Environmental democracy provides the basis for the policies and government actions that may ensure that the use of natural resources is equitable and sustainable at a time. Based on environmental problems of global dimensions such as climate change, environmental degradation, and energy crisis, the proposal of efficient means of assuring peaceful wellbeing of humanity is necessary. Even though it is not exclusively a legal nor a political problem, world governance will strongly rely on coherent and efficient implementation of environmental democracy throughout the current century. This paper will explore and identify the role of environmental law and environmental democracy in particular, for the achievement of governance and democracy in general, trying to ensure sustainable development considering global environmental issues. This will be done through the analysis of elements contained in traditional soft law instruments, as well as those contained under economical and political international instruments influenced by sustainable development policies, trying to identify and propose the possibility of current innovative environmental governance policies

Using Law to Advance Sustainability: The Law of Sustainable Development

Sustainability and law as a social tool behold linkages that strengthen one another, although this conjunction is frail when analyzed under the typical standards and paradigm of most contemporary legal systems. The role of law under sustainability must be carefully profiled and differentiated as compared to the rest of legal rules. Even though it is true that all legal rules are created and implemented with the main purpose of improving human interaction, the role of law oriented towards sustainability should be the protection and preservation of natural resources, elements, as well as the conditions associated to these in order to guarantee the development and well being of the human race. As it has been declared by other environmental law scholars, there should be a “sustainable development law”, referring to the fact that certain sustainability based main principles should be introduced and recognized considering that the largest and most widely spread legal systems were unable to recognize them. The identity of a new legal paradigm strongly based on the current environmental paradigm should be recognized and legal systems throughout the globe should implement and enforce it in order to assure a sustainable development approach through law. Any argument of modern environmental law should be based in several focal aspects that will be identified, reasoned and proposed in this paper, as well as this proposed identity and character of the modern legal paradigm which embraces and strengthens sustainability

Herbal product use by persons enrolled in the hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial

Herbal products, used for centuries in Far Eastern countries, are gaining popularity in western countries. Surveys indicate that persons with chronic hepatitis C (CHC) often use herbals, especially silymarin (milk thistle extract), hoping to improve the modest response to antiviral therapy and reduce side effects. The Hepatitis C Antiviral Long-Term Treatment Against Cirrhosis (HALT-C) Trial, involving persons with advanced CHC, nonresponders to prior antiviral therapy but still willing to participate in long-term pegylated interferon treatment, offered the opportunity to examine the use and potential effects of silymarin. Among 1145 study participants, 56% had never taken herbals, 21% admitted past use, and 23% were using them at enrollment. Silymarin constituted 72% of 60 herbals used at enrollment. Among all participants, 67% had never used silymarin, 16% used it in the past, and 17% used it at baseline. Silymarin use varied widely among the 10 participating study centers; men were more frequent users than women, as were non-Hispanic whites than African Americans and Hispanics. Silymarin use correlated strongly with higher education. No beneficial effect of silymarin was found on serum alanine aminotransferase or hepatitis C virus (HCV) RNA levels. Univariate analysis showed significantly fewer liver-related symptoms and better quality-of-life parameters in users than nonusers, but after reanalysis adjusted for covariates of age, race, education, alcohol consumption, exercise, body mass index, and smoking, only fatigue, nausea, liver pain, anorexia, muscle and joint pain, and general health remained significantly better in silymarin users. In conclusion, silymarin users had similar alanine aminotransferase and HCV levels to those of nonusers but fewer symptoms and somewhat better quality-of-life indices. Because its use among these HALT-C participants was self-motivated and uncontrolled, however, only a well-designed prospective study can determine whether silymarin provides benefit to persons with chronic hepatitis C. (H EPATOLOGY 2008.)Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/58026/1/22044_ftp.pd

A review of elliptical and disc galaxy structure, and modern scaling laws

A century ago, in 1911 and 1913, Plummer and then Reynolds introduced their models to describe the radial distribution of stars in `nebulae'. This article reviews the progress since then, providing both an historical perspective and a contemporary review of the stellar structure of bulges, discs and elliptical galaxies. The quantification of galaxy nuclei, such as central mass deficits and excess nuclear light, plus the structure of dark matter halos and cD galaxy envelopes, are discussed. Issues pertaining to spiral galaxies including dust, bulge-to-disc ratios, bulgeless galaxies, bars and the identification of pseudobulges are also reviewed. An array of modern scaling relations involving sizes, luminosities, surface brightnesses and stellar concentrations are presented, many of which are shown to be curved. These 'redshift zero' relations not only quantify the behavior and nature of galaxies in the Universe today, but are the modern benchmark for evolutionary studies of galaxies, whether based on observations, N-body-simulations or semi-analytical modelling. For example, it is shown that some of the recently discovered compact elliptical galaxies at 1.5 < z < 2.5 may be the bulges of modern disc galaxies.Comment: Condensed version (due to Contract) of an invited review article to appear in "Planets, Stars and Stellar Systems"(www.springer.com/astronomy/book/978-90-481-8818-5). 500+ references incl. many somewhat forgotten, pioneer papers. Original submission to Springer: 07-June-201

Discovery of a new class of inhibitors for the protein arginine deiminase type 4 (PAD4) by structure-based virtual screening

<p>Abstract</p> <p>Background</p> <p>Rheumatoid arthritis (RA) is an autoimmune disease with unknown etiology. Anticitrullinated protein autoantibody has been documented as a highly specific autoantibody associated with RA. Protein arginine deiminase type 4 (PAD4) is the enzyme responsible for catalyzing the conversion of peptidylarginine into peptidylcitrulline. PAD4 is a new therapeutic target for RA treatment. In order to search for inhibitors of PAD4, structure-based virtual screening was performed using LIDAEUS (Ligand discovery at Edinburgh university). Potential inhibitors were screened experimentally by inhibition assays.</p> <p>Results</p> <p>Twenty two of the top-ranked water-soluble compounds were selected for inhibitory screening against PAD4. Three compounds showed significant inhibition of PAD4 and their IC₅₀values were investigated. The structures of the three compounds show no resemblance with previously discovered PAD4 inhibitors, nor with existing drugs for RA treatment.</p> <p>Conclusion</p> <p>Three compounds were discovered as potential inhibitors of PAD4 by virtual screening. The compounds are commercially available and can be used as scaffolds to design more potent inhibitors against PAD4.</p

Latitude gradient influences the age of onset of rheumatoid arthritis : a worldwide survey

The age of onset of rheumatoid arthritis (RA) is an important outcome predictor. Northern countries report an age of RA onset of around 50 years, but apparently, variability exists across different geographical regions. The objective of the present study is to assess whether the age of onset of RA varies across latitudes worldwide. In a proof-of-concept cross-sectional worldwide survey, rheumatologists from preselected cities interviewed 20 consecutive RA patients regarding the date of RA onset (RAO, when the patient first noted a swollen joint). Other studied variables included location of each city, rheumatologist settings, latitudes (10A degrees increments, south to north), longitudes (three regions), intracountry consistency, and countries' Inequality-adjusted Human Development Index (IHDI). Data from 2481 patients (82% females) were obtained from 126 rheumatologists in 77 cities of 41 countries. Worldwide mean age of RAO was 44 +/- 14 years (95% CI 44-45). In 28% of patients, RA began before age 36 years and before age 46 years in 50% of patients. RAO was 8 years earlier around the Tropic of Cancer when compared with northern latitudes (p <0.001, 95% CI 3.5-13). Multivariate analysis showed that females, western cities, and latitudes around the Tropic of Cancer are associated with younger age of RAO (R (2) 0.045, p <0.001). A positive correlation was found between the age of RAO and IHDI (r = 0.7, p <0.01, R (2) 0.5). RA often begins at an early age and onset varies across latitudes worldwide. We postulate that countries' developmental status and their geographical and geomagnetic location influence the age of RAO.Peer reviewe