Representación del álgebra de Lie, leyes de conservación y algunas soluciones invariantes para una ecuación de Emden-Fowler generalizada

All generators of the optimal algebra associated with a generalization of the Endem-Fowler equation are showed; some of them allow to give invariant solutions. Variational symmetries and the respective conservation laws are also showed. Finally, a representation of Lie symmetry algebra is showed by groups of matrices.Se muestran todos los generadores del álgebra óptima asociados con una generalización de la ecuación de Endem-Fowler; algunos de ellos permiten dar soluciones invariantes. También se muestran las simetrías variacionales y las respectivas leyes de conservación. Finalmente, se muestra una representación del álgebra de simetría de Lie mediante grupos de matrices

Dermocystid infection and associated skin lesions in free-living palmate newts (Lissotriton helveticus) from Southern France

Since the early 1900s, mesomycetozoan parasites have been reported in both European anuran and caudate species. These reports have primarily been descriptive, which has made assessing the impact of these parasites on host populations difficult. Anecdotal reports of Dermocystidium-like parasites are becoming widespread across Europe, possibly indicating that these mesomycetozoan parasites are increasing in distribution and/or abundance. This highlights the need for further investigations into the occurrence, pathogenesis and effects on host health of these parasitic infections for free-living amphibian populations, particularly those which are already stressed or threatened by other factors. Here we report the results of pathological, microbiological and molecular investigations used to characterize unidentified skin lesions in palmate newts (Lissotriton helveticus) from Larzac, France. We confirm that the lesions are the result of infection with a novel dermocystidium-like parasite, which is related to Amphybiocystidium ranae. We also show that the same parasite is distributed across several newt breeding sites. The lesions that result from infection with this parasite range from single or few vesicular or nodular cutaneous lesions to multiple coalescing skin ulcers with extensive hemorrhages. The latter have not been previously described in amphibians due to mesomycetozoan parasitic infection. Dermocystid DNA was detected only in newts that showed lesions, providing comparative evidence of the parasite's pathogenicity. We discuss the potential significance of the presence of this pathogen in the context of the population health of palmate newts

Clasificación del álgebra de Lie, leyes de conservación y soluciones invariantes para un caso particular de la ecuación generalizada e Levinson-Smith

In this study, we examine a specific instance of the generalized Levinson-Smith equation, which is linked to the Liènard equation and holds significant importance from the perspectives of physics, mathematics, and engineering. This underlying equation has practical applications in mechanics and nonlinear dynamics and has been extensively explored in the qualitative scheme. Our approach involves applying the Lie group method to this equation. By doing so, we derive the optimal generating operators for the system that pertain to the specific instance of the generalized Levinson-Smith equation. These operators are then used to define all invariant solutions associated with the equation. In addition, we demonstrate the variational symmetries and corresponding conservation laws using Noether's theorem. Finally, we categorize the Lie algebra related to the given equation.En este estudio, examinamos una instancia específica de la ecuación generalizada de Levinson-Smith, que está vinculada con la ecuación de Liènard y tiene una gran importancia desde las perspectivas de la física, las matemáticas y la ingeniería. Esta ecuación subyacente tiene aplicaciones prácticas en mecánica y dinámica no lineal, y ha sido ampliamente explorada en el esquema cualitativo. Nuestro enfoque implica aplicar el método de grupos de Lie a esta ecuación. Al hacerlo, obtenemos los operadores generadores óptimos del sistema que se refieren a la instancia específica de la ecuación generalizada de Levinson-Smith. Luego, se utilizan estos operadores para definir todas las soluciones invariantes asociadas con la ecuación. Además, demostramos las simetrías variacionales y las leyes de conservación correspondientes utilizando el teorema de Noether. Finalmente, categorizamos el álgebra de Lie relacionada con la ecuación dada

Aequidens superomaculatum (Teleostei: Cichlidae) una nueva especie del alto Orinoco y Río Negro, Venezuela

A new species, Aequidens superomaculatum, is described from the Casiquiare Canal drainage and the upper reaches of the Orinoco and Negro rivers (Venezuela). This new species shares with others of the genus a vermiculated color pattern on the cheek, snout and preopercle and a high vertebral count, but it differs from congeners in having a continuous lateral stripe, and in having the lateral dark pigment blotch positioned high on both sides of the body.Se describe una nueva especie, Aequidens superomaculatum, proveniente de la cuenca del Caño o Brazo Casiquiare y la parte alta de las cuencas de los ríos Orinoco y Negro (Venezuela). Esta nueva especie comparte con otras especies del género previamente descritas, la presencia de un patrón de coloración vermiculado en la mejilla, hocico y preopérculo y un conteo vertebral alto, pero se diferencia de estas especies por la presencia de una banda lateral continua y la posición superior de la mancha lateral en ambos lados del cuerpo

Optimizing CIGB-300 intralesional delivery in locally advanced cervical cancer

Background:We conducted a phase 1 trial in patients with locally advanced cervical cancer by injecting 0.5 ml of the CK2-antagonist CIGB-300 in two different sites on tumours to assess tumour uptake, safety, pharmacodynamic activity and identify the recommended dose.Methods:Fourteen patients were treated with intralesional injections containing 35 or 70 mg of CIGB-300 in three alternate cycles of three consecutive days each before standard chemoradiotherapy. Tumour uptake was determined using 99 Tc-radiolabelled peptide. In situ B23/nucleophosmin was determined by immunohistochemistry.Results:Maximum tumour uptake for CIGB-300 70-mg dose was significantly higher than the one observed for 35 mg: 16.1±8.9 vs 31.3±12.9 mg (P=0.01). Both, AUC 24h and biological half-life were also significantly higher using 70 mg of CIGB-300 (P<0.001). Unincorporated CIGB-300 diffused rapidly to blood and was mainly distributed towards kidneys, and marginally in liver, lungs, heart and spleen. There was no DLT and moderate allergic-like reactions were the most common systemic side effect with strong correlation between unincorporated CIGB-300 and histamine levels in blood. CIGB-300, 70 mg, downregulated B23/nucleophosmin (P=0.03) in tumour specimens.Conclusion:Intralesional injections of 70 mg CIGB-300 in two sites (0.5 ml per injection) and this treatment plan are recommended to be evaluated in phase 2 studies.Fil: Sarduy, M. R.. Medical-surgical Research Center; CubaFil: García, I.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Coca, M. A.. Clinical Investigation Center; CubaFil: Perera, A.. Clinical Investigation Center; CubaFil: Torres, L. A.. Clinical Investigation Center; CubaFil: Valenzuela, C. M.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Baladrón, I.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Solares, M.. Hospital Materno Ramón González Coro; CubaFil: Reyes, V.. Center For Genetic Engineering And Biotechnology Havana; CubaFil: Hernández, I.. Isotope Center; CubaFil: Perera, Y.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Martínez, Y. M.. Medical-surgical Research Center; CubaFil: Molina, L.. Medical-surgical Research Center; CubaFil: González, Y. M.. Medical-surgical Research Center; CubaFil: Ancízar, J. A.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Prats, A.. Clinical Investigation Center; CubaFil: González, L.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Casacó, C. A.. Clinical Investigation Center; CubaFil: Acevedo, B. E.. Centro de Ingeniería Genética y Biotecnología; CubaFil: López Saura, P. A.. Centro de Ingeniería Genética y Biotecnología; CubaFil: Alonso, Daniel Fernando. Universidad Nacional de Quilmes; ArgentinaFil: Gómez, R.. Elea Laboratories; ArgentinaFil: Perea Rodríguez, S. E.. Center For Genetic Engineering And Biotechnology Havana; Cuba. Centro de Ingeniería Genética y Biotecnología; Cub

Lista de los peces del delta del río Orinoco, Venezuela

The list of freshwater, estuarine and marine fishes known from the Orinoco river delta in Venezuela is updated, corrected and expanded. Based on recent field work, revision of the literature and museum collections, a list of 438 species was assembled that includes nine new records for the region. These are grouped in 20 orders, 82 families and 281 genera. The orders with the most species are Characiformes (132), Perciformes (99) and Siluriformes (87). Most of the fishes were found in freshwater (71 %) with estuarine and marine species amounting to only 39 %. About one third (29 % - 127 sp.) have economic importance as fishery resources. Four introduced species were found, three exotic and one transported from another Venezuelan drainage

Lista de los peces del delta del río Orinoco, Venezuela

The list of freshwater, estuarine and marine fishes known from the Orinoco river delta in Venezuela is updated, corrected and expanded. Based on recent field work, revision of the literature and museum collections, a list of 438 species was assembled that includes nine new records for the region. These are grouped in 20 orders, 82 families and 281 genera. The orders with the most species are Characiformes (132), Perciformes (99) and Siluriformes (87). Most of the fishes were found in freshwater (71 %) with estuarine and marine species amounting to only 39 %. About one third (29 % - 127 sp.) have economic importance as fishery resources. Four introduced species were found, three exotic and one transported from another Venezuelan drainage.Se actualiza, corrige y amplía la lista de peces dulceacuícolas, marinos y estuarinos del delta del río Orinoco, Venezuela. Con base en el trabajo de campo, revisión bibliográfica y de colecciones, se elabora una lista de 438 especies, de las cuales nueve son nuevos registros para la región. Estas están agrupadas en 20 órdenes, 82 familias y 281 géneros. Los órdenes con mayor representación específica fueron Characiformes (132 sp.), Perciformes (99 sp.) y Siluriformes (87 sp.). En función de la salinidad se obtuvo que la mayoría de las especies (71 %) fueron de hábitos estrictamente dulceacuícolas, seguidas por las de hábitos estuarinos y marinos (39 %). Un tercio de las especies (29 % - 127 sp.), presentan importancia como recursos pesqueros. Se registran cuatro especies introducidas (tres exóticas y una trasplantada)

Chemical Composition, Starch Digestibility and Antioxidant Capacity of Tortilla Made with a Blend of Quality Protein Maize and Black Bean

Tortilla and beans are the basic components in the diet of people in the urban and rural areas of Mexico. Quality protein maize is suggested for tortilla preparation because it presents an increase in lysine and tryptophan levels. Beans contain important amounts of dietary fiber. The objective of this study was to prepare tortilla with bean and assesses the chemical composition, starch digestibility and antioxidant capacity using a quality protein maize variety. Tortilla with bean had higher protein, ash, dietary fiber and resistant starch content, and lower digestible starch than control tortilla. The hydrolysis rate (60 to 50%) and the predicted glycemic index (88 to 80) of tortilla decreased with the addition of bean in the blend. Extractable polyphenols and proanthocyanidins were higher in the tortilla with bean than control tortilla. This pattern produced higher antioxidant capacity of tortilla with bean (17.6 μmol Trolox eq/g) than control tortilla (7.8 μmol Trolox eq/g). The addition of bean to tortilla modified the starch digestibility and antioxidant characteristics of tortilla, obtaining a product with nutraceutical characteristics