Estimation of the antifungal activity of some preparations against Diaporthe eres under in vitro conditions

Six fungicides from various chemical groups and two natural products, i.e., Biosept Active (grapefruit extract) and Beta-Chikol (chitosan) were tested in vitro against Diaporthe eres isolated from the shoots of fruit trees. The preparations were incorporated in PDA medium to provide final fungicide concentrations of 1, 10, and 100 g cm−3. Biosept Active concentrations of 0.05%, 0.075%, and 0.1%, and Beta-Chikol concentrations of 1%, 2%, and 2.5%, respectively. The antifungal activity of the preparations was evaluated based on mycelial growth of D. eres strains after 4 and 8 days of culture and changes in the morphological structures of the fungus. The highest antifungal activity was registered for thiophanate-methyl at all tested concentrations, followed by thiram, which showed the same activity but only at 100 g cm−3. Among the preparations of natural origin, Beta-Chikol was more effective against D. eres than Biosept Active. The effects achieved by the former preparation were comparable with those achieved by some of the most effective fungicides tested against D. eres

Review of physiotherapeutic methods used in patients with osteoporosis

Chłystek Joanna, Pietsch Julia, Golus Anna, Abramczyk Agata, Łakomski Mateusz. Review of physiotherapeutic methods used in patients with osteoporosis. Journal of Education, Health and Sport. 2018;8(9):1058-1066 eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1420053 http://ojs.ukw.edu.pl/index.php/johs/article/view/6004 https://pbn.nauka.gov.pl/sedno-webapp/works/877731 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eissn 2391-8306 7 © The Authors 2018; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 02.08.2018. Revised: 18.08.2018. Accepted: 15.09.2018. Review of physiotherapeutic methods used in patients with osteoporosis Joanna Chłystek, Julia Pietsch, Anna Golus, Agata Abramczyk, Mateusz Łakomski Department and Clinic of Geriatrics, Collegium Medicum in Bydgoszcz, University of Nicolaus Copernicus in Torun Abstract This article is a review of current literature about physiotherapeutic methods used in osteoporosis including physical activity and physical therapy. Osteoporosis is a systemic disease classified as a civilization disease, which is significantly associated with gender, age, low body weight, and lifestyle. Most often it concerns older adults and is also characteristic for postmenopausal women. The research presented in this article suggests the positive influence of physiotherapy (i.e. aerobic exercises and resistance training and also physical therapy) on osteogenic processes, bone mineral density, pain and decrease the risk of falls. Keywords: Osteoporosis, Physiotherapeutic method

The effect of physical activity on mood - a review of current literature

The impact of physical activity on human health has many benefits. Equally important in improving physical fitness and normalizing cardiovascular system seems to be the impact of exercise on mood of patients. Physical activity improves well-being, satisfaction and self-confidence. However, the condition of effective therapeutic intervention is due to its regularity, since only systematic exercises allow to maintain the beneficial effects of physical activity. Otherwise, the results achieved are only temporary. This article aims to review the current literature and show the most important aspects of motion therapy in improving the psychophysical condition of patients

Resistance training for the elderly. Review of the literature

With age, there is a gradual decrease in muscle mass and strength, and the use of strength training contributes to the slowdown of this process. It is also recommended in older people due to the increase in bone mass. An important element of planning this type of training, including the advancement of the person exercising is their lifestyle and the results obtained in strength tests. Due to the age, remember to exercise caution when doing this type of exercise and monitor the course of the training, e.g. by controlling the exercising heart rate or using the Borg scale. Avoid extreme strength and endurance exhaustion as it results in an increase in blood pressure. Strength training brings a number of benefits, but unpredictably planned and conducted also a number of threats. It is indicated in some disease entities, e.g. obesity

Rehabilitation in rheumatoid arthritis

Rheumatoid arthritis is an inflammatory, chronic and progressive connective tissue disease. The causes of this disease are not fully known. About 0. 5 - 1. 5% of the population suffer from RA. This disease is more common in women. The treatment of RA should be comprehensive and include pharmacotherapy, physiotherapy and psychotherapy. It is also important to choose appropriate otropedic supplies. The presented studies indicate a positive effect of complex physiotherapeutic treatment on the reduction of pain and other symptoms of RA

Review of physiotherapeutic methods used in patients with osteoporosis

This article is a review of current literature about physiotherapeutic methods used in osteoporosis including physical activity and physical therapy. Osteoporosis is a systemic disease classified as a civilization disease, which is significantly associated with gender, age, low body weight, and lifestyle. Most often it concerns older adults and is also characteristic for postmenopausal women. The research presented in this article suggests the positive influence of physiotherapy (i.e. aerobic exercises and resistance training and also physical therapy) on osteogenic processes, bone mineral density, pain and decrease the risk of falls

Murine factor H co-produced in yeast with protein disulfide isomerase ameliorated C3 dysregulation in factor H-Deficient mice

Recombinant human factor H (hFH) has potential for treating diseases linked to aberrant complement regulation including C3 glomerulopathy (C3G) and dry age-related macular degeneration. Murine FH (mFH), produced in the same host, is useful for pre-clinical investigations in mouse models of disease. An abundance of FH in plasma suggests high doses, and hence microbial production, will be needed. Previously, Pichia pastoris produced useful but modest quantities of hFH. Herein, a similar strategy yielded miniscule quantities of mFH. Since FH has 40 disulfide bonds, we created a P. pastoris strain containing a methanol-inducible codon-modified gene for protein-disulfide isomerase (PDI) and transformed this with codon-modified DNA encoding mFH under the same promoter. What had been barely detectable yields of mFH became multiple 10s of mg/L. Our PDI-overexpressing strain also boosted hFH overproduction, by about tenfold. These enhancements exceeded PDI-related production gains reported for other proteins, all of which contain fewer disulfide-stabilized domains. We optimized fermentation conditions, purified recombinant mFH, enzymatically trimmed down its (non-human) N-glycans, characterised its functions in vitro and administered it to mice. In FH-knockout mice, our de-glycosylated recombinant mFH had a shorter half-life and induced more anti-mFH antibodies than mouse serum-derived, natively glycosylated, mFH. Even sequential daily injections of recombinant mFH failed to restore wild-type levels of FH and C3 in mouse plasma beyond 24 hours after the first injection. Nevertheless, mFH functionality appeared to persist in the glomerular basement membrane because C3-fragment deposition here, a hallmark of C3G, remained significantly reduced throughout and beyond the ten-day dosing regimen

Interdyscyplinarne aspekty nauk o zdrowiu

Praca recenzowana / Peer-reviewed pape

Expectations of diabetes patients within the scope of education in the light of nationwide research

Wstęp. Edukacja odgrywa istotną rolę w profilaktyce chorób społecznych i jest integralną częścią opieki nad chorym. Cel pracy. W pracy przedstawiono oczekiwania chorych na cukrzycę w zakresie edukacji. Materiał i metody. Badania przeprowadzono wśród 1986 pacjentów i 1366 rodzin z losowo wybranych 61 zakładów podstawowej opieki zdrowotnej w kraju. Badano pacjentów z cukrzycą w wieku powyżej 16. roku życia, mieszkających w rejonie pracy pielęgniarki środowiskowej (rodzinnej) i zarejestrowanych na liście lekarza rodzinnego. Badania przeprowadzono na podstawie: ukierunkowanego wywiadu pielęgniarskiego, relatywnej oceny sprawności i samodzielności pacjentów, anonimowej ankiety wśród pacjentów i rodzin, analizy dokumentacji lekarza rodzinnego. Wyniki. Wyniki badań wykazały, że częściej niż co drugi chory na cukrzycę oczekuje edukacji (59,4%). Osoby chore na cukrzycę różnią się otwartością na edukację zdrowotną. Wnioski. 1. Znajomość czynników różnicujących oczekiwania w zakresie edukacji wśród chorych na cukrzycę pozwala na optymalizację troski o zdrowie i wskaźników jakości leczenia cukrzycy oraz przyczynia się do wzrostu satysfakcji pacjentów i ich rodzin z efektów leczenia cukrzycy i opieki. 2. Satysfakcja pacjentów z udziału w życiu rodziny, małżeńskim i zawodowym pozwala na poprawę skuteczności edukacji zdrowotnej prowadzonej wśród tej grupy chorych. Problemy Pielęgniarstwa 2010; 18 (3): 249-259Introduction. Education plays a significant role in the prophylaxis of social diseases and is an integral part of patient care. Aim of the study. The paper presents the expectations of diabetes patients within the scope of education. Material and methods. For the purpose of this work, research was carried out on 1,986 patients with diabetes and 1366 families from 61 randomly chosen national primary health service units. Research materials were obtained from the patients aged above 16 years old, living in the area of work of a social and family nurse and are registered on the list of the local GP. The research was conducted on the basis of: guided nurse interviews, relative assessment of fitness and independence of the patients, anonymous questionnaire which allows to obtain patients’ opinions, anonymous questionnaire conducted among families and analysis of the medical documentation. Results. The results of the conducted research show that more than half diabetes patients expect education (59.4%). Persons suffering from diabetes vary in their openness to health education. Conclusions. 1. Being aware of the factors which contribute to varying expectations within the scope of education among diabetes patients makes it possible to optimize health care, quality indicators for diabetes treatment and increased satisfaction of patients and their families with the effects of diabetes treatment and care. 2. Patients’ satisfaction with their participation in family, married and professional lives makes it possible to increase the effectiveness of health education carried out among this group of patients. Nursing Topics 2010; 18 (3): 249-25

Masa ciała, zachowania i sytuacja zdrowotno-społeczna chorych na cukrzycę na poziomie podstawowej opieki zdrowotnej: w świetle badań ogólnopolskich

Background: Multiple health and economic consequences related to obesity cause it to be regarded as a problem of socialsignificance; body mass control has become a crucial element in the process of diabetes treatment.Aim: This paper shows factors differentiating body mass values in diabetes patients.Methods: The research for this study was carried out among 1,986 patients with diabetes, originating from 61 randomlychosen units of the national primary health care system.Results: Normal body mass was found only in 12.8% of patients. Normal body mass was found in patients characterised bya better (moderate) level of knowledge about the disease (p < 0.005) and with full knowledge of health indicators significantin diabetes treatment (p < 0.05). Patients with normal body mass function in families were characterised by a more completecapacity to care and support the patient in the home environment (p < 0.0001), a more favourable socio-living situation(p < 0.05), with less requirement for professional care (p < 0.0001). Persons with normal body mass more frequently showedblood pressure (p < 0.0001), triglyceride concentrations (p < 0.0001) and total cholesterol concentrations (p < 0.0001) closeto normal. Obesity was most frequently recognised in patients who declared no physical activity or excessive physical activity(regardless of the recommendation to dose physical effort and activity) (p < 0.01).Conclusions: The obtained results show that the levels of health consciousness, healthy behaviours, and family and socio-livingsituations differentiate the body mass values defined by body mass index in diabetic patients.Wstęp: Liczne konsekwencje zdrowotne i ekonomiczne wynikające z otyłości powodują, że uznano ją za problem o znaczeniuspołecznym, a kontrola masy ciała stała się zasadniczym elementem procesu leczenia cukrzycy.Cel: W pracy przedstawiono czynniki różnicujące wielkość masy ciała wśród chorych na cukrzycę .Metody: Badania przeprowadzono wśród 1986 pacjentów z losowo wybranych 61 zakładów podstawowej opieki zdrowotnejw kraju.Wyniki: Prawidłową masę ciała ustalono jedynie u 12,8% chorych — pacjentów, których charakteryzował korzystniejszy(umiarkowany) poziom wiedzy o chorobie (p < 0,005) i pełna znajomość wskaźników zdrowia istotnych w leczeniu cukrzycy(p = 0,05). Pacjenci z masą ciała w granicach normy częściej funkcjonują w rodzinie charakteryzującej się pełną wydolnościąw zakresie opieki i wspomagania chorego w środowisku domowym (p < 0,0001), korzystniejszą sytuacją socjalno-bytową(p < 0,05), mniejszym, umiarkowanym zapotrzebowaniem na profesjonalną opiekę (p < 0,0001). Wśród osób z prawidłowąmasą ciała częściej stwierdzano najbliższe normie ciśnienie krwi (p < 0,0001), stężenie triglicerydów (p < 0,0001) i cholesterolucałkowitego (p < 0,0001). Otyłość najczęściej ustalono wśród chorych, którzy deklarowali brak aktywności fizycznejlub podejmowania nadmiernego wysiłku fizycznego (nie respektowali zaleceń w zakresie dozowania wysiłku i aktywnościfizycznej) (p < 0,01).Wnioski: Przeprowadzone badania wykazały, że poziom świadomości zdrowotnej, zachowania zdrowotne, sytuacja rodzinnai socjalno-bytowa różnicują wielkość masy ciała określoną wskaźnikiem masy ciała u chorych na cukrzycę