De Facto Judicial Independence and Physical Integrity Rights

Economists, political scientists, and legal scholars have argued that independent judiciaries have an important role to play in promoting economic development and protecting property rights. We argue that judicial independence can also have a positive impact on the protection of human rights. To assess the human rights impact of a de facto independent judiciary, we also argue that scholars must account for the potential of endogeneity between judicial independence and protection of human rights. We examine whether greater de facto independence improves government respect for citizens’ physical integrity rights, using a comprehensive dataset of 193 countries from 1981 to 2010. Employing an instrumental variables approach to control for endogeneity, we find strong support for the argument that greater levels of de facto judicial independence improve government respect for physical integrity rights. These findings are robust to changes in measurement, estimation techniques, and model specification. Failing to account for endogeneity will tend to overemphasize the ability of completely independent courts to improve government respect for physical integrity rights

War and infant mortality rates

War represents one of the gravest threats to the right to health. A range of international human rights covenants have enumerated the rights of both adults and children to lead full healthy lives, free from the dangers of war. Yet we know remarkably little about how war systematically affects children’s rights to health. We have limited knowledge about if different types of conflict—major interstate and major civil wars—have similar or different consequences for children’s health. This article examines the immediate and cumulative links of major interstate and major civil wars with infant mortality rates, a key measure of children’s health. The article employs generalized least squares regression with two-way fixed effects over the 1950–2007 period. The core results indicate that major civil and major interstate wars substantively violate children’s and infants’ rights to health. States that spent the most amount of time involved in major interstate wars were associated with the worst overall increases in infant mortality rates

Trade and Strike Activity in the Postwar United States

This paper examines the effect of international trade on strike activity within the United States since World War II. Globalization may influence strike activity through its effects on the bargaining position of labor. Alternatively, if labor and management take their changed bargaining positions into account, the rate of change in openness could create greater uncertainty in negotiations between them and lead to more strikes as a result. Empirical analysis of strike activity in the 50 states over this period supports the argument concerning uncertainty in the bargaining process. Import competition may also indirectly reduce strike activity by decreasing union density

International Organizations and the Quality of Domestic Governance: the Multiple Principals Problem

Previous research generally ignores the costs of international cooperation. Using the principal-agent framework, we draw attention to the agency loss that occurs domestically when multiple international actors simultaneously influence national policy makers. We contribute to the literature by emphasizing the potentially negative consequences of competition between international organizations and citizens for influence over domestic politicians. Drawing upon previous theoretical and empirical work on the multiple principals-common-agent problem, we hypothesize that the joint influence of a country’s memberships in multiple international governmental organizations (IGOs) generates consistent, unintended, disruptive effects on governance. The empirical part of the paper applies our theoretical expectations to indicators of the quality of domestic governance. The results support our argument and show that the disruptive effect is strongest in less democratic countries

Economic Development and the World Bank

We contribute to the research stream examining the effects of World Bank lending programs on economic growth in developing economies. We contend that it is important to distinguish between the short-term effects and extended exposure of countries to these lending programs and also to assess the Bank’s (late 1990s) reforms to improve the effectiveness of these programs in recipient countries to assess whether program lending has any positive impacts on economic growth. Our comparative cross-national findings using instrumental variables analysis to control for endogeneity between program participation and economic growth demonstrate that both the short-term and longer exposure to program lending worsens economic growth. We find no evidence that World Bank reforms improved economic growth rates in the post-reform (1999–2009) period. Our findings are robust to changes in model specifications and estimation techniques. Future research should examine whether these reforms had beneficial impacts in other societal areas affected by program lending

Rapid Breast Cancer Disease Progression Following Cyclin Dependent Kinase 4 and 6 Inhibitor Discontinuation.

Background: CDK 4 and 6 inhibitors (CDK4/6i), which arrest unregulated cancer cell proliferation, show clinical efficacy in breast cancer. Unexpectedly, a patient treated on a CDK4/6i-based trial, as first-line therapy in metastatic breast cancer, developed rapid disease progression following discontinuation of study drug while receiving standard second-line therapy off trial. We thus sought to expand this observation within a population of patients treated similarly at The University of Texas MD Anderson Cancer Center. Methods: Using an IRB-approved protocol, 4 patients previously enrolled on CDK4/6i trials were analyzed for outcomes after discontinuing study drug. These patients were treated on a randomized trial of first-line endocrine therapy +/- a CDK4/6i. Rapid disease progression was defined as progression occurring within 4 months of CDK4/6i discontinuation. Results: In total, 4 patients developed rapid disease progression and died; 2 of whom died within 6 months of CDK4/6i discontinuation. Conclusion: This case series suggests a potential for rapid disease progression following CDK4/6i discontinuation. However, the clinical course following progression must be validated in large CDK4/6i clinical trials and standard-of-care cohorts. If confirmed, such observations may alter the algorithm for subsequent therapy in patients with disease progression on CDK4/6i. Nevertheless, the need remains to define a mechanistic basis for this rapid progression and formulate alternative therapeutic strategies

National variation in prophylactic antibiotic use for elective primary total joint replacement an analysis of guidelines across hospitals and trusts in the UK

Aims Prophylactic antibiotic regimens for elective primary total hip and knee arthroplasty vary widely across hospitals and trusts in the UK. This study aimed to identify antibiotic prophylaxis regimens currently in use for elective primary arthroplasty across the UK, establish variations in antibiotic prophylaxis regimens and their impact on the risk of periprosthetic joint infection (PJI) in the first-year post-index procedure, and evaluate adherence to current international consensus guidance. Methods The guidelines for the primary and alternative recommended prophylactic antibiotic regimens in clean orthopaedic surgery (primary arthroplasty) for 109 hospitals and trusts across the UK were sought by searching each trust and hospital’s website (intranet webpages), and by using the MicroGuide app. The mean cost of each antibiotic regimen was calculated using price data from the British National Formulary (BNF). Regimens were then compared to the 2018 Philadelphia Consensus Guidance, to evaluate adherence to international guidance. Results The primary choice and dosing of the prophylactic antimicrobial regimens varied widely. The two most used regimens were combined teicoplanin and gentamicin, and cefuroxime followed by two or three doses of cefuroxime eight-hourly, recommended by 24 centres (22.02%) each. The alternative choice and dosing of the prophylactic antimicrobial regimen also varied widely across the 83 centres with data available. Prophylaxis regimens across some centres fail to cover the likeliest causes of surgical site infection (SSI). Five centres (4.59%) recommend co-amoxiclav, which confers no Staphylococcus coverage, while 33 centres (30.28%) recommend cefuroxime, which confers no Enterococcus coverage. Limited adherence to 2018 Philadelphia Consensus Guidance was observed, with 67 centres (61.50%) not including a cephalosporin in their guidance. Conclusion This analysis of guidance on antimicrobial prophylaxis in primary arthroplasty across 109 hospitals and trusts in the UK has identified widespread variation in primary and alternative antimicrobial regimens currently recommended

Inequality and Human Rights: Who Controls What, When, and How

This article tests the empirical relationship between inequality and the protection of personal integrity rights using a cross-national time-series data set for 162 countries for the years 1980?2004. The data comprise measures of land inequality, income inequality, and a combined factor score for personal integrity rights protection, while the analysis controls for additional sets of explanatory variables related to development, political regimes, ethnic composition, and domestic conflict. The analysis shows robust support for the empirical relationship between income inequality and personal integrity rights abuse across the whole sample of countries as well as for distinct subsets, including non-communist countries and non-OECD countries. The hypothesized effect of land inequality is also born out by the data, although its effects are less substantial and less robust across different methods of estimation. Additional variables with explanatory weight include the level of income, democracy, ethnic fragmentation, domestic conflict, and population size. Sensitivity analysis suggests that the results are not due to reverse causation, misspecification or omitted variable bias. The analysis is discussed in the context of inequality and rights abuse in specific country cases and the policy implications of the results are considered in the conclusion

A new dataset on infant mortality rates, 1816-2002

Systematic data on annual infant mortality rates are of use to a variety of social science research programs in demography, economics, sociology, and political science. Infant mortality rates may be used both as a proxy measure for economic development, in lieu of energy consumption or GDP-per-capita measures, and as an indicator of the extent to which governments provide for the economic and social welfare of their citizens. Until recently, data were available for only a limited number of countries based on regional or country-level studies and time periods for years after 1950. Here, the authors introduce a new dataset reporting annual infant mortality rates for all states in the world, based on the Correlates of War state system list, between 1816 and 2002. They discuss past research programs using infant mortality rates in conflict studies and describe the dataset by exploring its geographic and temporal coverage. Next, they explain some of the limitations of the dataset as well as issues associated with the data themselves. Finally, they suggest some research areas that might benefit from the use of this dataset. This new dataset is the most comprehensive source on infant mortality rates currently available to social science researchers