The causes of slavery: a hypothesis

Presented to the Economic History Associatio

Título: Aprovación y censura de gravissimos maestros pavordes y doctores peritissimos ...

Autor tomado de final de textoEl texto alude al año 1640Sign.: []1, A7Letra inic. con grab. xi

RESEARCH ON THE SELECTION OF EXCIPIENTS AS THE RATIONALE FOR THE COMPOSITION OF THE TABLETS WITH DRY EXTRACT OF SANGUISORBA OFFICINALIS

The aim. The aim of the research was to study the effect of different groups of excipients on the pharmaco-technological propertiesof the powder mass for tabletting in the development of the composition of the tablets with dry extract of Sanguisorba officinalis for complex therapy of the gastrointestinal tract diseases. Materials and methods. Objects of study - dry extract Sanguisorba officinalis, 25 excipients used in the production of tablets by the method of direct compression, grouped into five groups of factors (fillers based on sugars and microcrystalline cellulose, disintegrants, glidants and lubricants), samples of powder masses. Studies on the determination of pharmaco-technological properties (fluidity, bulk density, bulk density after shrinkage, degree of compressibility, Hausner ratio, and angle of repose) of the obtained powder masses were carried out according to the methods of the State Pharmacopoeia of Ukraine, Second edition. The method of mathematical planning of the experiment was used in the work, the obtained results were subjected to variance analysis, and the ranked series of advantages were placed, in which the excipients were placed in the sequence of their influence on the studied pharmaco-tecnological parameters. Results and discussion. The influence of excipients (factors) on the pharmaco-technological properties (responses) of the powdered tablet masses with the construction of ranked benefits was studied using a five-factor experiment, a hyper-Graeco-Latin square. The results of the analysis of variance showed that glidants have the greatest influence on the fluidity, the bulk density and the bulk density after shrinkage. Neusilin US 2 significantly affects the fluidity of the powder masses and Hausner ratio, the talc having the greatest effect on the bulk density and the bulk density after shrinkage of the powder masses. The representative of the disintegrants group – Sodium starch glycolate most influences the compressibility index, the sugar-based filler – Pearlitol 500 DC – on the angle of repose. Conclusions. The effect of 25 excipients on the pharmaco-technological characteristics of the powdered tablet masses with dry extract of Sanguisorba officinalis was studied. It was found that among the sugars-based fillers equally good results were shown in the powder masses with Compri sugar, Tablettose 80 and Pearlitol 500 DC; among the microcrystalline cellulose based fillers is Prosolv 90; among glidants – Neusilin US 2; no comparison was made of the disintegrants and lubricant excipients from the studied list of leader substances. The results of the studies indicate the possibility of obtaining tablets by the direct compression method, and further study of their pharmaco-technological characteristics will allow to establish the optimal composition of excipients

Une devise canadienne ou plusieurs? : la question de l'optimalité de la zone monétaire canadienne à travers l'étude de chocs exogènes dans un cadre VECM

L'objectif de cette étude est de savoir si la fédération des provinces du Canada forme aujourd’hui une zone monétaire optimale. Les travaux précédents ont suggéré que l’espace monétaire canadien soit divisé en deux espaces, l’un de l’Est et l’autre de l’Ouest. Notre méthodologie, qui intègre des données des Etats-Unis et du cours du pétrole WTI, fait ressortir l’existence de deux zones économiques pouvant se doter de leur propre devise. L’analyse par VECM montre l’existence d’une relation de long terme entre les provinces canadiennes, les États-Unis et le cours du pétrole. Une interprétation possible de nos résultats est que ceux-ci suggèrent que le Canada devrait avoir deux monnaies distinctes une pour la zone de l’Ouest (Alberta/Colombie-Britannique), une pour la zone de l’Est (Québec/Ontario/Nouveau-Brunswick).The aim of this study is to assess whether the federation of the provinces of Canada today form an optimal currency area. Previous work has sometimes suggested that the Canadian monetary zone be divided into two spaces, one in the East and the other in the West. Our methodology, which incorporate data from the United States and WTI oil prices, highlights the existence of two economic areas that could develop their own currency. VECM analysis shows the existence of a long-term relationship between the Canadian provinces, the United States and oil prices. The results can be interpreted as suggesting that Canada should have two separate currencies for an area of the West (Alberta / British Columbia), one for the area (Quebec/Ontario/New-Brunswick)

Aprouacion y censura de grauissimos maestros, pauordres, y doctores peritissimos, los quales son del mismo parecer del Doctor Ioseph Palomeres, en razon de que la profession de fray Agustin Domar fue valida, y que se le deue de restituyr el habito ...

Autor tomado de final de textoEl texto alude al año 1640Sign.: []1, A7Letra inic. con grab. xi