Chemical constituents of Centaurea cadmea

WOS: 00025335430001

Antioxidant lignans from Larrea tridentata

PubMed ID: 15381414Three lignans, (7S,8S,7'S,8'S)-3,3',4'-trihydroxy- 4-methoxy-7,7'-epoxylignan and meso-(rel 7S,8S,7'S,8'S)-3,4, 3',4'-tetrahydroxy-7,7'-epoxylignan with significant antioxidant properties, and (E)-4,4'-dihydroxy-7,7'-dioxolign- 8(8')-ene, were isolated from the leaves of Larrea tridentata. The structures of the new compounds were determined primarily from 1D and 2D NMR analysis. Their antioxidant activities were evaluated on intracellular reactive oxygen species in HL-60 cells. Three lignans, (7S,8S,7'S,8'S)-3, 3',4'-trihydroxy-4-methoxy-7,7'-epoxylignan, meso-(rel 7S,8S,7'R,8'R)-3,4,3',4'-tetrahydroxy-7, 7'-epoxylignan, and (E)-4,4'-dihydroxy-7,7'-dioxolign- 8(8')-ene, together with 10 known compounds, were isolated from the leaves of Larrea tridentata. The structures of the new compounds were determined primarily from 1D and 2D NMR spectroscopic analysis. Their antioxidant activities against intracellular reactive oxygen species were evaluated in HL-60 cells. © 2004 Published by Elsevier Ltd.U.S. Department of Agriculture American Radium Society: 58-6408-2-0009 Food and Drug Administration: FD-U-002071-01This work was supported in part by the United States Department of Agriculture, ARS Specific Cooperative Research Agreement No. 58-6408-2-0009, and funded by Food and Drug Administration, Grant No: FD-U-002071-01 “Botanical Dietary Supplements: Science-Base for Authentication”. We are grateful to Dr. Chuck Dunbar for conducting the HR-ESI-FTMS analysis and Mr. Frank Wiggers for his assistance in obtaining the 2D NMR spectra. -