Colonizer to Drug Resistant isolate, What is Happening to our Staphylococcus Aureus?

Objective: To evaluate resistant trend of multiple antimicrobial agents against Staphylococcus aureus isolates along with its prevalence.  Material and Methods: This prospective descriptive study was carried out in the department of microbiology Allama Iqbal Medical College Lahore from 1st January 2015 to 25 may 2016. Simple random technique was used, and 4570 clinical samples (Pus, blood, pleural fluid, tracheal aspirate, urine, sputum, HVS) were received from ICU, Surgical Unit, Medical Unit and OPD for culture sensitivity testing, antimicrobial resistant trend was tested according to CLSI guidelines  Results: Maximum isolates were recovered from surgical unit 31.9%, sample-wise maximum isolates were recovered from pus samples 26.8%. age group and genderbased distribution showed among male’s high isolation rate was observed in 21-40 years while in females 41-60-year age group. Every isolate was (100%) susceptible to linezolid, vancomycin and teicoplanin, cotrimoxazole also showed very low rate of drug resistance only 8.3%, while penicillin Doxycycline, Ciprofloxacin, Erythromycin showed 95.9%,69.8%55.4% and 48.2% drug resistance respectively, 43-45% drugresistant rate observed in case of Co-amoxiclave, Methicillin, Gentamicin, Fusidic Acid, Amikacin, and Clindamycin  Conclusion: Linezolid, Vancomycin, and Teicoplanin are best therapeutic Choices against Staphylococcus aureus associated infections

ULTRASONOGRAPHIC EVALUATION OF LOWER UTERINE SEGMENT THICKNESS IN PREGNANT WOMEN WITH PREVIOUS CESAREAN SECTION: A SYSTEMATIC REVIEW

Background: Nowadays it’s a big problem of lower uterine thickness in pregnant women that causes a lot of problems. Lower uterine segment thickness is a strong predictor for uterine scar defect in women with prior caesarian section. Lower segment cesarean section (LSCS) rates are raising throughout the world. Women with previous one cesarean can undergo either the trial of vaginal birth or elective repeat cesarean section in their next pregnancy. The study aims to assess the diagnostic accuracy of sonographic measurement of lower uterine segment thickness in pregnant women So there we are going to evaluate lower uterine segment thickness in pregnant women sonographically by using transabdominal and transvaginal approaches as well. Objective: To evaluate lower uterine segment thickness in pregnant women with previous caesarian section by sonography. Materials and Methods: An electronic data base search was performed through the searches using PubMed, Google Scholar, international Journal of Gynecology & obstetrics and some other online journals and medical websites with the range from 2000-2021. All studies included in the research was in English language. Articles which had descriptive studies related to sonographic features of lower uterine segment thickness of pregnant women with C-section. Results: Research data of 200 patients in all studies showed that Transvaginal ultrasound provided greater reliability in LUS measurements than did transabdominal ultrasound. The use of three-dimensional ultrasound improved significantly the reliability of the LUS muscular thickness measurement obtained transvaginal Conclusion: We identified certain sonographic patterns that can accurately shows the lower uterine segment thickness in pregnant women with previous caesarian section. Keywords: LUS lower uterine segment thickness, Transabdominal and Transvaginal ultrasonography, Pregnancy, Caesarian Section DOI: 10.7176/JHMN/93-07 Publication date:September 30th 202

The Integration of Conventional Equity Indices with Environmental, Social, and Governance Indices: Evidence from Emerging Economies

This study investigates the integration of environmental, social, and governance (ESG) equity indices with conventional indices in Brazil, Russia, India, China, and South Africa (BRICS) individually and across all BRICS countries to better understand regional economic cooperation. Accordingly, we look at daily returns from 13 July 2013 to 28 February 2018 for the Morgan Stanley Capital International (MSCI) ESG indices and MSCI composite indices of the respective countries. To analyze the integration between the ESG equity indices of the sampled countries with their regional and across regional conventional counterparts, the Johansen Co-integration test is employed in this study. Further, the vector error correction model (VECM) is applied to test the causality between the sampled time-series. The impulse response function analysis further explains the impulse responses of each country’s MSCI ESG returns to one standard deviation of innovations to MSCI composite returns of the same country and across countries. Finally, the extent of the MSCI composite returns’ impact on the MSCI ESG returns in the same country indices, and cross-regional indices is examined with variance decomposition analysis. The results suggest that all ESG equity indices are integrated with conventional indices in all BRICS countries. Furthermore, there is a short-or long-run causality between MSCI ESG and MSCI composite equity indices of China and South Africa. Moreover, the study finds only short-run causality between conventional and non-conventional equity indices of Brazil and Russia, whereas we find only long-run causality between India’s non-conventional and conventional equity indices. Finally, the study finds that the all-individual country MSCI ESG equity indices shows a long-run causality with MSCI composite equity indices of all other BRICS countries. The findings also confirm the economic and financial cooperation between the BRICS countries

Evaluation of Cervical Disc Degeneration in Patients with Neck Pain on Magnetic Resonance Imaging

Background: Cervical disc degeneration is the most common pathology that in most of the cases  clinically present as Objective: To evaluate the cervical region abnormalities in patients with neck pain on magnetic resonance imaging. Methodology: In this descriptive study 180 adult patients were included. All patients had been collected from DHQ hospital Gilgit and Ghurki Trust teaching hospital. After informed consent, data were collected through 1.5 tesla GE (closed bore) and 0.35 tesla Hitachi (open bore) MRI machines. Results:  Findings show that among 180 adult patients, 136 presented with disc degeneration among which 81 were males and 55 were females. Among 81 males, 63 had disc degeneration at multiple levels while 18 had single disc degeneration. In females 35 patients showed multiple disc degeneration while 20 involved a single disc. Conclusion: It is concluded that disc degeneration is prevalent in males than females. Disc degeneration at multiple levels is higher than single disc degeneration in both genders. Keywords: Disc degeneration, magnetic resonance imaging. DOI: 10.7176/JHMN/99-03 Publication date: April 30th 2022

Assessment of total phenolic and flavonoid contents of selected fruits and vegetables

686-693This work was conceptualized with the goal to investigate different fruits and vegetables for their comparative investigation of total phenolic and total flavonoid contents. The total phenolic content of 9 fruits and 12 vegetables used in the current study was determined by Folin-Ciocalteau assay. In addition, total flavonoid content was identified through catechin and aluminum colorimetric analysis. The ratio among the phenolic and flavonoid contents of fruits and vegetables extracts were also analyzed. Our results showed that methanolic extract of Citrullus lanatus had higher contents of phenolics and flavonoids (215±1.24 mg GAE/100 g and 73±0.81 mg CE/100 g) than other fruits. Moreover, maturity process of fruits from unripened to fully ripened stage showed significant increase in the total phenolic and flavonoid contents. Fruits under study had shown flavonoids/phenolics ratio of 0.32, which indicates that these fruits contained about 32% of flavonoid contents. Among vegetables, the greatest value of phenolic contents was observed in Capsicum annuum (213±1.24 mg GAE/100 g), and total flavonoid content in Raphanus sativus (45±1.24 mg CE/100 g). Vegetables showed lower ratios of flavonoids/phenolics (0.11-0.2) indicating lesser total flavonoid content (11-20%) as compared with fruits. The obtained results indicate that fruits and vegetables could be attributed to a potential source of natural phenolics and flavonoids in the pharmaceutical and food industry. Moreover, the antioxidant activities of these selected fruits and vegetables should also be determined in order to explore their beneficial effects against the prevention and management of disorders caused by oxidative stress

Thrombosis with thrombocytopenia syndrome after administration of AZD1222 or Ad26.COV2.S vaccine for COVID-19: A systematic review

Background: Cases of thrombosis with thrombocytopenia syndrome (TTS) have been reported following vaccination with AZD1222 or Ad26.COV2.S. This review aimed to explore the pathophysiology, epidemiology, diagnosis, management, and prognosis of TTS.Methods: A systematic review was conducted to identify evidence on TTS till 4th September 2021. Case reports and series reporting patient-level data were included. Descriptive statistics were reported and compared across patients with different sexes, age groups, vaccines, types of thrombosis, and outcomes.Findings: Sixty-two studies reporting 160 cases were included from 16 countries. Patients were predominantly females with a median age of 42.50 (22) years. AZD1222 was administered to 140 patients (87·5%). TTS onset occurred in a median of 9 (4) days after vaccination. Venous thrombosis was most common (61.0%). Most patients developed cerebral venous sinus thrombosis (CVST; 66.3%). CVST was significantly more common in female vs male patients (p = 0·001) and in patients aged \u3c45 years vs ≥45 years (p = 0·004). The mortality rate was 36.2%, and patients with suspected TTS, venous thrombosis, CVST, pulmonary embolism, or intraneural complications, patients not managed with non-heparin anticoagulants or IVIG, patients receiving platelet transfusions, and patients requiring intensive care unit admission, mechanical ventilation, or inpatient neurosurgery were more likely to expire than recover.Interpretation: These findings help to understand the pathophysiology of TTS while also recommending diagnostic and management approaches to improve prognosis in patients.Funding: This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors

Comparative efficacy of phosphate solubilizing bacteria and synthetic phosphate fertilizers on the growth of wheat

Wheat is recognized as one of the most important dietary elements due to its high nutritious content and thus, has become greatest food option all over the world. Phosphorus (P) being major plant food nutrient plays a vital role multiple functions of plant growth and development. The current study was carried out to compare the performance of phosphate solubilizing bacteria (PSB) as bio-fertilizer with commercially available phosphate fertilizers on wheat crop. The trial was designed in randomized complete block (RCB) replicated thrice. 6 different sources of phosphate fertilizers (Di-ammonium phosphate as DAP, Nitrophos as NP, Single super phosphate as SSP, Restore as PSB, Marathon as PSB, Nitrogen (N2) fixing bacteria as PSB) followed by control were evaluated for agronomic, physiological and quality attributes of wheat. The results showed that most of the qualitative traits were significantly influenced by different treatments. However, application of N2 fixing bacteria was more significant in all treatments. Highest total viable count of colony-forming units (14.63×106 at 3-WAS & 17.70×106 after harvest CFU g-1), maximum tillers’ count (337 m-2), grains’ count (45.57 spike-1), grain yield (2714.3 kg ha-1), LAI (0.67 & 1.16 at 56 & 112 DAS), CGR (13.59 g day-1 m-2), photosynthesis rate (26.13 µ mol m-2 sec-1) and flag leaf sugar content (0.24%) were recorded on account of using N2-fixing bacteria applied as PSB. Moreover, NPK content in shoot, grain as well as uptake of NPK by grain were also received as highest in the same treatment. Based on research findings, it is concluded that application of N2-fixing bacteria as PSB (7.5 kg ha-1) might be increasing wheat production in Dera Ismail Khan and other areas of similar environment in Pakistan

Assessment of total phenolic and flavonoid contents of selected fruits and vegetables

This work was conceptualized with the goal to investigate different fruits and vegetables for their comparative investigation of total phenolic and total flavonoid contents. The total phenolic content of 9 fruits and 12 vegetables used in the current study was determined by Folin-Ciocalteau assay. In addition, total flavonoid content was identified through catechin and aluminum colorimetric analysis. The ratio among the phenolic and flavonoid contents of fruits and vegetables extracts were also analyzed. Our results showed that methanolic extract of Citrullus lanatus had higher contents of phenolics and flavonoids (215±1.24 mg GAE/100 g and 73±0.81 mg CE/100 g) than other fruits. Moreover, maturity process of fruits from unripened to fully ripened stage showed significant increase in the total phenolic and flavonoid contents. Fruits under study had shown flavonoids/phenolics ratio of 0.32, which indicates that these fruits contained about 32% of flavonoid contents. Among vegetables, the greatest value of phenolic contents was observed in Capsicum annuum (213±1.24 mg GAE/100 g), and total flavonoid content in Raphanus sativus (45±1.24 mg CE/100 g). Vegetables showed lower ratios of flavonoids/phenolics (0.11-0.2) indicating lesser total flavonoid content (11-20%) as compared with fruits. The obtained results indicate that fruits and vegetables could be attributed to a potential source of natural phenolics and flavonoids in the pharmaceutical and food industry. Moreover, the antioxidant activities of these selected fruits and vegetables should also be determined in order to explore their beneficial effects against the prevention and management of disorders caused by oxidative stress

Dynamic Price-Based Demand Response through Linear Regression for Microgrids with Renewable Energy Resources

The green innovations in the energy sector are smart solutions to meet the excessive power requirements through renewable energy resources (RERs). These resources have forwarded the revolutionary relief in control of carbon dioxide gaseous emissions from traditional energy resources. The use of RERs in a heuristic manner is necessary to meet the demand side management in microgrids (MGs). The pricing scheme limitations hinder the profit maximization of MG and their customers. In addition, recent pricing schemes lack mechanistic underpinning. Therefore, a dynamic electricity pricing scheme through linear regression is designed for RERs to maximize the profit of load customers (changeable and unchangeable) in MG. The demand response optimization problem is solved through the particle swarm optimization (PSO) technique. The proposed dynamic electricity pricing scheme is evaluated under two different scenarios. The simulation results verified that the proposed dynamic electricity pricing scheme sustained the profit margins and comforts for changeable and unchangeable load customers as compared to fixed electricity pricing schemes in both scenarios. Hence, the proposed dynamic electricity pricing scheme can readily be used for real microgrids (MGs) to grasp the goal for cleaner energy production

Smart Grid, Demand Response and Optimization: A Critical Review of Computational Methods

In view of scarcity of traditional energy resources and environmental issues, renewable energy resources (RERs) are introduced to fulfill the electricity requirement of growing world. Moreover, the effective utilization of RERs to fulfill the varying electricity demands of customers can be achieved via demand response (DR). Furthermore, control techniques, decision variables and offered motivations are the ways to introduce DR into distribution network (DN). This categorization needs to be optimized to balance the supply and demand in DN. Therefore, intelligent algorithms are employed to achieve optimized DR. However, these algorithms are computationally restrained to handle the parametric load of uncertainty involved with RERs and power system. Henceforth, this paper focuses on the limitations of intelligent algorithms for DR. Furthermore, a comparative study of different intelligent algorithms for DR is discussed. Based on conclusions, quantum algorithms are recommended to optimize the computational burden for DR in future smart grid