35 research outputs found
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Iridium Corroles Exhibit Weak Near-Infrared Phosphorescence but Efficiently Sensitize Singlet Oxygen Formation.
Six-coordinate iridium(III) triarylcorrole derivatives, Ir[TpXPC)]L2, where TpXPC = tris(para-X-phenyl)corrole (X = CF3, H, Me, and OCH3) and L = pyridine (py), trimethylamine (tma), isoquinoline (isoq), 4-dimethylaminopyridine (dmap), and 4-picolinic acid (4pa), have been examined, with a view to identifying axial ligands most conducive to near-infrared phosphorescence. Disappointingly, the phosphorescence quantum yield invariably turned out to be very low, about 0.02 - 0.04% at ambient temperature, with about a two-fold increase at 77 K. Phosphorescence decay times were found to be around ~5 µs at 295 K and ~10 µs at 77 K. Fortunately, two of the Ir[TpCF3PC)]L2 derivatives, which were tested for their ability to sensitize singlet oxygen formation, were found to do so efficiently with quantum yields Φ(1O2) = 0.71 and 0.38 for L = py and 4pa, respectively. Iridium corroles thus may hold promise as photosensitizers in photodynamic therapy (PDT). The possibility of varying the axial ligand and of attaching biotargeting groups at the axial positions makes iridium corroles particularly exciting as PDT drug candidates
A thermally stable {FeNO}(8) complex: properties and biological reactivity of reduced MNO systems
Reduced nitrogen oxide ligands such as NO−/HNO or nitroxyl participate in chemistry distinct from nitric oxide (NO). Nitroxyl has been proposed to form at heme centers to generate the Enemark–Feltham designated {FeNO}8 system. The synthesis of a thermally stable {FeNO}8 species namely, [Co(Cp*)2][Fe(LN4)(NO)] (3), housed in a heme-like ligand platform has been achieved by reduction of the corresponding {FeNO}7 complex, [Fe(LN4)(NO)] (1), with decamethylcobaltocene [Co(Cp*)2] in toluene. This complex readily reacts with metMb, resulting in formation of MbNO via reductive nitrosylation by the coordinated HNO/NO−, which can be inhibited with GSH. These results suggest that 3 could serve as a potential HNO therapeutic. Spectroscopic, theoretical, and structural comparisons are made to 1 and the {CoNO}8 complex, [Co(LN4)(NO)] (2), an isoelectronic analogue of 3
Absorbing Phase Transition in a Four State Predator Prey Model in One Dimension
The model of competition between densities of two different species, called
predator and prey, is studied on a one dimensional periodic lattice, where each
site can be in one of the four states say, empty, or occupied by a single
predator, or occupied by a single prey, or by both. Along with the pairwise
death of predators and growth of preys, we introduce an interaction where the
predators can eat one of the neighboring prey and reproduce a new predator
there instantly. The model shows a non-equilibrium phase transition into a
unusual absorbing state where predators are absent and the lattice is fully
occupied by preys. The critical exponents of the system are found to be
different from that of the Directed Percolation universality class and they are
robust against addition of explicit diffusion.Comment: 10 pages, 6 figures, to appear in JSTA
Constraining the epoch of reionization with the variance statistic: simulations of the LOFAR case
Several experiments are underway to detect the cosmic redshifted 21-cm signal
from neutral hydrogen from the Epoch of Reionization (EoR). Due to their very
low signal-to-noise ratio, these observations aim for a statistical detection
of the signal by measuring its power spectrum. We investigate the extraction of
the variance of the signal as a first step towards detecting and constraining
the global history of the EoR. Signal variance is the integral of the signal's
power spectrum, and it is expected to be measured with a high significance. We
demonstrate this through results from a simulation and parameter estimation
pipeline developed for the Low Frequency Array (LOFAR)-EoR experiment. We show
that LOFAR should be able to detect the EoR in 600 hours of integration using
the variance statistic. Additionally, the redshift () and duration
() of reionization can be constrained assuming a parametrization. We
use an EoR simulation of and to test the
pipeline. We are able to detect the simulated signal with a significance of 4
standard deviations and extract the EoR parameters as and in 600 hours,
assuming that systematic errors can be adequately controlled. We further show
that the significance of detection and constraints on EoR parameters can be
improved by measuring the cross-variance of the signal by cross-correlating
consecutive redshift bins.Comment: 13 pages, 14 figures, Accepted for publication in MNRA
Physics Potential of the ICAL detector at the India-based Neutrino Observatory (INO)
The upcoming 50 kt magnetized iron calorimeter (ICAL) detector at the
India-based Neutrino Observatory (INO) is designed to study the atmospheric
neutrinos and antineutrinos separately over a wide range of energies and path
lengths. The primary focus of this experiment is to explore the Earth matter
effects by observing the energy and zenith angle dependence of the atmospheric
neutrinos in the multi-GeV range. This study will be crucial to address some of
the outstanding issues in neutrino oscillation physics, including the
fundamental issue of neutrino mass hierarchy. In this document, we present the
physics potential of the detector as obtained from realistic detector
simulations. We describe the simulation framework, the neutrino interactions in
the detector, and the expected response of the detector to particles traversing
it. The ICAL detector can determine the energy and direction of the muons to a
high precision, and in addition, its sensitivity to multi-GeV hadrons increases
its physics reach substantially. Its charge identification capability, and
hence its ability to distinguish neutrinos from antineutrinos, makes it an
efficient detector for determining the neutrino mass hierarchy. In this report,
we outline the analyses carried out for the determination of neutrino mass
hierarchy and precision measurements of atmospheric neutrino mixing parameters
at ICAL, and give the expected physics reach of the detector with 10 years of
runtime. We also explore the potential of ICAL for probing new physics
scenarios like CPT violation and the presence of magnetic monopoles.Comment: 139 pages, Physics White Paper of the ICAL (INO) Collaboration,
Contents identical with the version published in Pramana - J. Physic
HI 21cm Cosmology and the Bi-spectrum: Closure Diagnostics in Massively Redundant Interferometric Arrays
New massively redundant low frequency arrays allow for a novel investigation
of closure relations in interferometry. We employ commissioning data from the
Hydrogen Epoch of Reionization Array to investigate closure quantities in this
densely packed grid array of 14m antennas operating at 100 MHz to 200 MHz. We
investigate techniques that utilize closure phase spectra for redundant triads
to estimate departures from redundancy for redundant baseline visibilities. We
find a median absolute deviation from redundancy in closure phase across the
observed frequency range of about 4.5deg. This value translates into a
non-redundancy per visibility phase of about 2.6deg, using prototype
electronics. The median absolute deviations from redundancy decrease with
longer baselines. We show that closure phase spectra can be used to identify
ill-behaved antennas in the array, independent of calibration. We investigate
the temporal behavior of closure spectra. The Allan variance increases after a
one minute stride time, due to passage of the sky through the primary beam of
the transit telescope. However, the closure spectra repeat to well within the
noise per measurement at corresponding local sidereal times (LST) from day to
day. In future papers in this series we will develop the technique of using
closure phase spectra in the search for the HI 21cm signal from cosmic
reionization.Comment: 32 pages. 11 figures. Accepted to Radio Scienc
Molecular structure of a free-base β-Octaiodo -meso-tetraarylporphyrin. A rational route to cis porphyrin tautomers?
Although a cis tautomer has long been invoked as an intermediate in porphyrin tautomerism, the first such species was only recently isolated and structurally characterized in the form of a β-heptakis(trifluoromethyl)-meso-tetraarylporphyrin. Reported herein is the molecular structure of a β-octaiodo-meso-tetraarylporphyrin solvate, which also exhibits a cis tautomeric structure. Both structures implicate two factors as critical to the stabilization of the cis tautomeric form - a free-base porphyrin that is naturally strongly saddled on steric grounds and a hydroxylic or amphiprotic solvent that can provide hydrogen-bonded N-H···X-H···N (X = O in both the above examples) straps connecting the central NH groups with the antipodal unprotonated nitrogens. The results raise the prospect that a rational strategy affording cis porphyrin tautomers in a predictable manner may be within reach.</p
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Synthesis and Molecular Structure of a Copper Octaiodocorrole.
Although rather delicate on account of their propensity to undergo deiodination, β-octaiodoporphyrinoids are of considerable interest as potential precursors to novel β-octasubstituted macrocycles. Presented herein are early results of our efforts to synthesize β-octaiodocorrole derivatives. Oxidative condensation of 3,4-diiodopyrrole and aromatic aldehydes failed to yield free-base octaiodocorroles. Treatment of copper meso-tris(p-cyanophenyl)corrole with N-iodosuccinimide and trifluoroacetic acid over several hours, however, yielded the desired β-octaiodinated product in ∼22% yield. Single-crystal X-ray structure determination of the product revealed a strongly saddled corrole macrocycle with metrical parameters very close to those of analogous Cu octabromocorrole complexes. The compound was also found to exhibit an exceptionally red-shifted Soret maximum (464 nm in dichloromethane), underscoring the remarkable electronic effect of β-octaiodo substitution
Simple, Axial Ligand-Mediated Route to Water-Soluble Iridium Corroles
The synthesis and purification of water-soluble porphyrin-type compounds for photodynamic therapy and other medical applications is often a tedious exercise. Here, we have investigated the simple stratagem of adding a water-soluble axial ligand to the standard protocol for iridium insertion into simple meso-triarylcorroles. Early results showed that six-coordinate Ir[TpXPC](dna)2 derivatives, in which TpXPC = tris(para-X-phenyl)corrole (X = CF3, CN, H, and OMe) and dna = dinicotinic acid, are highly water-soluble. In the end, however, all axially nitrogen-ligated complexes proved unstable with respect to chromatographic purification and storage. Five-coordinate water-soluble phosphine adducts, fortunately, proved a great improvement. From the point of view of ease of purification and storage, the best products proved to be Ir[TpXPC](L), where X = CF3 and OMe and L = tris(2-carboxyethyl)phosphine (tcep) and trisodium tris(3-sulfonatophenyl)phosphine (tppts); carefully optimized synthetic protocols are presented for these four compounds