56 research outputs found
Patient Safety in the Cardiac Operating Room: Human Factors and Teamwork: A Scientific Study from the American Heart Association
The cardiac surgical operating room (OR) is a complex environment in which highly trained subspecialists interact with each other using sophisticated equipment to care for patients with severe cardiac disease and significant comorbidities. Thousands of patient lives have been saved or significantly improved with the advent of modern cardiac surgery. Indeed, both mortality and morbidity for coronary artery bypass surgery have decreased during the past decade. Nonetheless, the highly skilled and dedicated personnel in cardiac ORs are human and will make errors. Refined techniques, advanced technologies, and enhanced coordination of care have led to significant improvements in cardiac surgery outcomes
Bacterial endotoxin effect on liver plasma membranes (LPM): membrane-bound enzymes as probes of the site of interaction
Endotoxin treatment of isolated hepatocytes reduces chlorpromazine-induced aspartate transaminase release
Prevention of the toxicity of erythromycin estolate in the perfused rat liver by endotoxin.
The possibility that endotoxin pretreatment could prevent the hepatotoxic effects
of erythromycin estolate (EE) was investigated using the isolated perfused rat
liver. The addition of E. coli endotoxin (25 micrograms/ml) to the perfusate, 30
min prior to EE administration at 150 or 200 microM, significantly ameliorated
the decreases in bile and perfusate flow caused by either concentrations of the
drug in control liver preparations. This phenomenon was also studied using liver
isolated from rats pretreated in vivo with endotoxin for three days. In these
preparations, EE at both concentrations did not alter bile flow and caused
reductions of perfusate flow which were far less than those observed in untreated
control livers. Furthermore, in livers from endotoxin-treated rats EE induced
less reduction of bile acid excretion and, at 150 microM, it did not increase the
bile to perfusate ratio of sucrose seen in control preparations after the drug,
which may be an expression of altered hepatocytic membrane permeability. Since it
is known that both endotoxin and EE interact with membranes, it is suggested that
the "protective" effects of endotoxin may occur at the membrane level
Taurocholate but not dehydrocholate can reverse the cholestatic effects of estradiol-17-B-glucuronide in the isolated perfused rat liver
Reduction of taurolithocholic acid-induced cholestasis in the isolated perfused rat liver by endotoxin treatment
Abs. n. 65
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