Improved High Contrast Imaging with On-Axis Telescopes using a Multi-Stage Vortex Coronagraph

The vortex coronagraph is one of the most promising coronagraphs for high contrast imaging because of its simplicity, small inner working angle, high throughput, and clear off-axis discovery space. However, as with most coronagraphs, centrally-obscured on-axis telescopes degrade contrast. Based on the remarkable ability of vortex coronagraphs to move light between the interior and exterior of pupils, we propose a method, based on multiple vortices, that, without sacrificing throughput, reduces the residual light leakage to (a/A)^n, with n >=4, and a and A being the radii of the central obscuration and primary mirror, respectively. This method thus enables high contrasts to be reached even with an on-axis telescope.Comment: 3 pages, 2 figure

Radially truncated galactic discs

We present the first results of a systematic analysis of radially truncated exponential discs for four galaxies of a complete sample of disc-dominated edge-on spiral galaxies. The discs of our sample galaxies are truncated at similar radii on either side of their centres. With possible the exception of the disc of ESO 416-G25, it appears that the truncations in our sample galaxies are closely symmetric, in terms of both their sharpness and the truncation length. However, the truncations occur over a larger region and not as abruptly as found in previous studies. We show that the truncated luminosity distributions of our sample galaxies, if also present in the mass distributions, comfortably meet the requirements for longevity. The formation and maintenance of disc truncations are likely closely related to stability requirements for galactic discs.Comment: 11 pages LaTeX, incl. 7 postscript figures, MNRAS, accepted; major revisions include

Probing the atmosphere of a solar-like star by galactic microlensing at high magnification

We report a measurement of limb darkening of a solar-like star in the very high magnification microlensing event MOA 2002-BLG-33. A 15 hour deviation from the light curve profile expected for a single lens was monitored intensively in V and I passbands by five telescopes spanning the globe. Our modelling of the light curve showed the lens to be a close binary system whose centre-of-mass passed almost directly in front of the source star. The source star was identified as an F8-G2 main sequence turn-off star. The measured stellar profiles agree with current stellar atmosphere theory to within ~4% in two passbands. The effective angular resolution of the measurements is <1 micro-arcsec. These are the first limb darkening measurements obtained by microlensing for a Solar-like star.Comment: Accepted for publication in A&A Letters. 5 pages, 2 embedded colour ps figures plus 1 jpg figure. Version with all figures embedded available from: http://www.roe.ac.uk/~iab/moa33paper

Vav2 Is an Activator of Cdc42, Rac1, and RhoA

Vav and Vav2 are members of the Dbl family of proteins that act as guanine nucleotide exchange factors (GEFs) for Rho family proteins. Whereas Vav expression is restricted to cells of hematopoietic origin, Vav2 is widely expressed. Although Vav and Vav2 share highly related structural similarities and high sequence identity in their Dbl homology domains, it has been reported that they are active GEFs with distinct substrate specificities toward Rho family members. Whereas Vav displayed GEF activity for Rac1, Cdc42, RhoA, and RhoG, Vav2 was reported to exhibit GEF activity for RhoA, RhoB, and RhoG but not for Rac1 or Cdc42. Consistent with their distinct substrate targets, it was found that constitutively activated versions of Vav and Vav2 caused distinct transformed phenotypes when expressed in NIH 3T3 cells. In contrast to the previous findings, we found that Vav2 can act as a potent GEF for Cdc42, Rac1, and RhoA in vitro. Furthermore, we found that NH(2)-terminally truncated and activated Vav and Vav2 caused indistinguishable transforming actions in NIH 3T3 cells that required Cdc42, Rac1, and RhoA function. In addition, like Vav and Rac1, we found that Vav2 activated the Jun NH(2)-terminal kinase cascade and also caused the formation of lamellipodia and membrane ruffles in NIH 3T3 cells. Finally, Vav2-transformed NIH 3T3 cells showed up-regulated levels of Rac-GTP. We conclude that Vav2 and Vav share overlapping downstream targets and are activators of multiple Rho family proteins. Therefore, Vav2 may mediate the same cellular consequences in nonhematopoietic cells as Vav does in hematopoietic cells

Time-Dependent CP Violation Effects in Partially Reconstructed B0→D∗πB^0 \to D^* \pi Decays

We report measurements of time-dependent decay rates for $B^0 \to D^{*\mp} \pi^\pm$ decays and extraction of CP violation parameters related to $\phi_3$. We use a partial reconstruction technique, whereby signal events are identified using information only from the primary pion and the charged pion from the decay of the $D^{*\mp}$. The analysis uses $140 {\rm fb}^{-1}$ of data accumulated at the $\Upsilon(4S)$ resonance with the Belle detector at the KEKB asymmetric-energy $e^{+}e^{-}$ collider. We measure the CP violation parameters $S^+ = 0.035 \pm 0.041 ({\rm stat}) \pm 0.018 ({\rm syst})$ and $S^- = 0.025 \pm 0.041 ({\rm stat}) \pm 0.018 ({\rm syst})$.Comment: 15 pages, 5 figures. To appear in Physics Letters

Stress corrosion cracking in Al-Zn-Mg-Cu aluminum alloys in saline environments

Copyright 2013 ASM International. This paper was published in Metallurgical and Materials Transactions A, 44A(3), 1230 - 1253, and is made available as an electronic reprint with the permission of ASM International. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplications of any material in this paper for a fee or for commercial purposes, or modification of the content of this paper are prohibited.Stress corrosion cracking of Al-Zn-Mg-Cu (AA7xxx) aluminum alloys exposed to saline environments at temperatures ranging from 293 K to 353 K (20 °C to 80 °C) has been reviewed with particular attention to the influences of alloy composition and temper, and bulk and local environmental conditions. Stress corrosion crack (SCC) growth rates at room temperature for peak- and over-aged tempers in saline environments are minimized for Al-Zn-Mg-Cu alloys containing less than ~8 wt pct Zn when Zn/Mg ratios are ranging from 2 to 3, excess magnesium levels are less than 1 wt pct, and copper content is either less than ~0.2 wt pct or ranging from 1.3 to 2 wt pct. A minimum chloride ion concentration of ~0.01 M is required for crack growth rates to exceed those in distilled water, which insures that the local solution pH in crack-tip regions can be maintained at less than 4. Crack growth rates in saline solution without other additions gradually increase with bulk chloride ion concentrations up to around 0.6 M NaCl, whereas in solutions with sufficiently low dichromate (or chromate), inhibitor additions are insensitive to the bulk chloride concentration and are typically at least double those observed without the additions. DCB specimens, fatigue pre-cracked in air before immersion in a saline environment, show an initial period with no detectible crack growth, followed by crack growth at the distilled water rate, and then transition to a higher crack growth rate typical of region 2 crack growth in the saline environment. Time spent in each stage depends on the type of pre-crack (“pop-in” vs fatigue), applied stress intensity factor, alloy chemistry, bulk environment, and, if applied, the external polarization. Apparent activation energies (E a) for SCC growth in Al-Zn-Mg-Cu alloys exposed to 0.6 M NaCl over the temperatures ranging from 293 K to 353 K (20 °C to 80 °C) for under-, peak-, and over-aged low-copper-containing alloys (~0.8 wt pct), they are typically ranging from 20 to 40 kJ/mol for under- and peak-aged alloys, and based on limited data, around 85 kJ/mol for over-aged tempers. This means that crack propagation in saline environments is most likely to occur by a hydrogen-related process for low-copper-containing Al-Zn-Mg-Cu alloys in under-, peak- and over-aged tempers, and for high-copper alloys in under- and peak-aged tempers. For over-aged high-copper-containing alloys, cracking is most probably under anodic dissolution control. Future stress corrosion studies should focus on understanding the factors that control crack initiation, and insuring that the next generation of higher performance Al-Zn-Mg-Cu alloys has similar longer crack initiation times and crack propagation rates to those of the incumbent alloys in an over-aged condition where crack rates are less than 1 mm/month at a high stress intensity factor

MicroRNAs targeting oncogenes are down-regulated in pancreatic malignant transformation from benign tumors

BACKGROUND MicroRNA (miRNA) expression profiles have been described in pancreatic ductal adenocarcinoma (PDAC), but these have not been compared with pre-malignant pancreatic tumors. We wished to compare the miRNA expression signatures in pancreatic benign cystic tumors (BCT) of low and high malignant potential with PDAC, in order to identify miRNAs deregulated during PDAC development. The mechanistic consequences of miRNA dysregulation were further evaluated. METHODS Tissue samples were obtained at a tertiary pancreatic unit from individuals with BCT and PDAC. MiRNA profiling was performed using a custom microarray and results were validated using RT-qPCR prior to evaluation of miRNA targets. RESULTS Widespread miRNA down-regulation was observed in PDAC compared to low malignant potential BCT. We show that amongst those miRNAs down-regulated, miR-16, miR-126 and let-7d regulate known PDAC oncogenes (targeting BCL2, CRK and KRAS respectively). Notably, miR-126 also directly targets the KRAS transcript at a "seedless" binding site within its 3'UTR. In clinical specimens, miR-126 was strongly down-regulated in PDAC tissues, with an associated elevation in KRAS and CRK proteins. Furthermore, miR-21, a known oncogenic miRNA in pancreatic and other cancers, was not elevated in PDAC compared to serous microcystic adenoma (SMCA), but in both groups it was up-regulated compared to normal pancreas, implicating early up-regulation during malignant change. CONCLUSIONS Expression profiling revealed 21 miRNAs down-regulated in PDAC compared to SMCA, the most benign lesion that rarely progresses to invasive carcinoma. It appears that miR-21 up-regulation is an early event in the transformation from normal pancreatic tissue. MiRNA expression has the potential to distinguish PDAC from normal pancreas and BCT. Mechanistically the down-regulation of miR-16, miR-126 and let-7d promotes PDAC transformation by post-transcriptional up-regulation of crucial PDAC oncogenes. We show that miR-126 is able to directly target KRAS; re-expression has the potential as a therapeutic strategy against PDAC and other KRAS-driven cancers

Measurement of proton proton elastic scattering in pure initial spin states at 11.75 GeV/c

The elastic cross section for proton proton scattering at 11.75 GeV/c was measured at the Argonne ZGS using a 50% polarized target. In the range p[perpendicular]2=0.6 --&gt; 2.2 (GeV/c)2 we obtained precise measurements of d[sigma]/dt(ij) for the [two upwards arrow] [two down arrows], and [up and down arrow]; initial spin states perpendicular to the scattering plane. We confirmed that the asymmetry parameter, A, decreases with energy in the diffraction peak, but is approximately energy-independent at large p[perpendicular]2. We found that the spin correlation parameter cnn acquires rather dramatic structure, and at large p[perpendicular]2 seems to grow with energy.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/21719/1/0000111.pd

Study of B+- --> D_CP K+- and D^*_CP K+- decays

We report a study of the modes D_CP K+- and D^*_CP K+- where D^(*) decays to CP eigenstates. The data sample used contains 275 x 10^6 BB events at the Upsilon(4S) resonance collected by the Belle detector at the KEKB energy-asymmetric e^+ e^- collider. The CP asymmetries obtained for D_CP K are: A_1 = 0.06 +- 0.14 (stat) +- 0.05 (sys), A_2 = -0.12 +- 0.14 (stat) +- 0.05 (sys) and for D^*_CP K : A_1^* = -0.20 +- 0.22 (stat) +- 0.04 (sys), A_2^* = 0.13 +- 0.30 (stat) +- 0.08 (sys).Comment: 10 pages, 7 figures, submitted to Phys.Rev.D (Rapid Communications