Diş hekimliği fakültelerinde kullanılan farklı diş ünitlerinin su ünitlerinin su sistemlerinin geri akım kontaminasyonu açısından değerlendirilmesi

Amaç: Farklı diş koltuk sistemlerine bağlı gerikaçış engelleyici sistemlerin etkinliğinin uzun dönem araştırılması ve farklı branşlara göre gerikaçış sonucu ortaya çıkabilecek çapraz enfeksiyon riskinin belirlenmesidir. Gereç ve Yöntemler: Dişhekimliğinin birbirinden farklı üç branşından çalışma grubu oluşturulmuştur. Bu farklı üç gruptan elde edilen materyaller bakteri varlığı açısından değerlendirilerek gruplar arasındaki farklılık mikrobiyolojik açıdan incelenmiştir. Bulgular: Üç grupta da birçok bakteri kolonisinin izole edildiği görülmekle birlikte üreyen mikroorganizmaların çoğunun çevreden ve ağız florasından sıklıkla izole edilen bakteri kolonileri olduğu görülmüştür. Sonuç: Diş ünit sistemlerinin kontaminasyonu engelleyici sistemlerle donatılmasının son derece önemli olduğu görülmüş, bununla birlikte uzun zamandır kullanılan diş ünit sistemlerinin sıklıkla kontrol edilmesi ve gerektiğinde yenilenmesi sonucuna ulaşılmıştır

The frequency of Duchenne muscular dystrophy/Becker muscular dystrophy and Pompe disease in children with isolated transaminase elevation: results from the observational VICTORIA study

IntroductionElevated transaminases and/or creatine phosphokinase can indicate underlying muscle disease. Therefore, this study aims to determine the frequency of Duchenne muscular dystrophy/Becker muscular dystrophy (DMD/BMD) in male children and Pompe disease (PD) in male and female children with isolated hypertransaminasemia.MethodsThis multi-center, prospective study enrolled patients aged 3–216 months with serum alanine transaminase (ALT) and/or aspartate transaminase (AST) levels >2× the upper limit of normal (ULN) for ≥3 months. Patients with a known history of liver or muscle disease or physical examination findings suggestive of liver disease were excluded. Patients were screened for creatinine phosphokinase (CPK) levels, and molecular genetic tests for DMD/BMD in male patients and enzyme analysis for PD in male and female patients with elevated CPK levels were performed. Genetic analyses confirmed PD. Demographic, clinical, and laboratory characteristics of the patients were analyzed.ResultsOverall, 589 patients [66.8% male, mean age of 63.4 months (standard deviation: 60.5)] were included. In total, 251 patients (188 male and 63 female) had CPK levels above the ULN. Of the patients assessed, 47% (85/182) of male patients were diagnosed with DMD/BMD and 1% (3/228) of male and female patients were diagnosed with PD. The median ALT, AST, and CPK levels were statistically significantly higher, and the questioned neurological symptoms and previously unnoticed examination findings were more common in DMD/BMD patients than those without DMD/BMD or PD (p < 0.001).DiscussionQuestioning neurological symptoms, conducting a complete physical examination, and testing for CPK levels in patients with isolated hypertransaminasemia will prevent costly and time-consuming investigations for liver diseases and will lead to the diagnosis of occult neuromuscular diseases. Trial RegistrationClinicaltrials.gov NCT04120168

Design of novel binuclear phthalocyanines formed by dioxyphenyl bridges: Synthesis and investigation of thermal and antioxidant properties

4,4_-(1,4-Phenylenebis(oxy)diphthalonitrile was synthesized by reaction of hydroquinone with 4-nitrophthalonitrile. Binuclear metallophthalocyanines 2–4 were obtained by the reaction between 4,4_-(1,4-phenylenebis(oxy)diphthalonitrile and 4-(benzo [d] [1,3] dioxol- 5-ylmethoxy)phthalonitrile in the presence of metal salts. These new compounds were characterized by using elemental analysis, FTIR, 1H-NMR and UV/Vis spectroscopic data. Thermal properties of phthalocyanines 2-4 were investigated by TG and DTA. In addition, antioxidant properties of compounds II, 3 and 4 were investigated. Their radical-scavenging capacity and chelating effects was fully studied. The maximum 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH) were obtained from compound 3. Chelating effects on ferrous ions were 91.6 % at concentration of 100 mgL–1 with compound II

Synthesis and antioxidant, aggregation, and electronic properties of 6-tert-butyl-1,4-benzodioxine substituted phthalocyanines

As a starting material, 7-tert-butyldibenzo [b,e] [1,4] dioxine-2,3-dicarbonitrile was prepared by the reac- tion of 4-tert-butylcatechol with 4,5-dichlorophthalonitrile. Metallophthalocyanine complexes ( 4 { 7 ) were obtained by cyclotetramerization of 7-tert-butyldibenzo [b,e] [1,4] dioxine-2,3-dicarbonitrile. All compounds were characterized by elemental analysis and other spectroscopic methods (IR, UV/Vis, and 1 H NMR). Phthalocyanine compounds remained nonaggregated in tetrahydrofuran at the studied concentration ranges. Metallophthalocyanines ( 4 { 7 ) were tested for their antioxidant activities. The antioxidant activity processes included evaluation of radical-scavenging activity, chelat- ing activity, and reducing power. These compounds were compared to standard antioxidant ascorbic acid. The electronic data of the new compounds were obtained by computational calculations at the B3LYP/6-31G (d,p) level of theory

CMOS enabled microfluidic systems for healthcare based applications

With the increased global population, it is more important than ever to expand accessibility to affordable personalized healthcare. In this context, a seamless integration of microfluidic technology for bioanalysis and drug delivery and complementary metal oxide semiconductor (CMOS) technology enabled data-management circuitry is critical. Therefore, here, the fundamentals, integration aspects, and applications of CMOS-enabled microfluidic systems for affordable personalized healthcare systems are presented. Critical components, like sensors, actuators, and their fabrication and packaging, are discussed and reviewed in detail. With the emergence of the Internet-of-Things and the upcoming Internet-of-Everything for a people–process–data–device connected world, now is the time to take CMOS-enabled microfluidics technology to as many people as possible. There is enormous potential for microfluidic technologies in affordable healthcare for everyone, and CMOS technology will play a major role in making that happen.King Abdullah University of Science and Technology (KAUST) Office of Sponsored Research (OSR) (OSR-2015-Sensors-2707 OSR-2016-KKI-2880) Technology Transfer Office (TTO) GEN-01-401